Andre Schwarz

Thank you for including some of our figures here. I thought the exact same and as it happens we did deposit a few (not all) ChimeraX sessions alongside the raw data and analysis code here (tree mode view is easier):
edmond.mpg.de/dataset.xhtm...
one of them including these disomes compared to others

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes pubmed.ncbi.nlm.nih.gov/41712727/ #cryoEM

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Thank you Matt!

Ribosomes in pairs: A survival strategy inside stressed cells.
When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA

www.science.org/doi/10.1126/...

co-first with: @andschwarz.bsky.social

with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more

🧵 0/6
#MolBio 🧪

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET

We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...

What a great example of collaborative science enabled by people sharing things early on. Well done @lifeonthewedge.bsky.social and others!

Likewise! will do :)

Hey Jeremy, it was great meeting you. I had a great time at SfN and the trip back flew by. Still impressed by the sheer magnitude of this conference and I learned a lot. How about you?

Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET!

🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...

I’m excited to share my PhD work on localized mRNAs and protein synthesis in cortical layer 1 on bioRxiv! www.biorxiv.org/content/10.1...

Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....

😅 yeah.. we should catch up soon..

#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪

Thank you Ben! We're pushing a small update this coming week and then on to other modalities that I still owe writing up 😅

Thank you Reika. Let's see how molecular profiling of cryo-ET develops in the next years. More to come :)

Likewise! I have an 18 h journey back from Madagascar so I'm downloading it right now.

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

I "read" (really listened to) it in two days straight following your recommendation. Brilliant book, I really love the style of chronological excerpts of different people in his life writing about him. Really gives weight to all the different angles of his personality. Keep the suggestions coming ;)

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

Excited to share our latest collaborative work from Erin Schuman's lab @mpibrain.bsky.social : An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution, now published in @natcomms.nature.com. Here’s a thread summary 🧵
doi.org/10.1038/s414...

The small GTPase Ran defines nuclear pore complex asymmetry Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…

My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!

Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!

Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo

We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...

Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...

Well done Noor and Pamela. Beautiful looking maps and nice summary including lovely cartoons as always :)

Beautiful. I loved every moment of this project ❤️