Clarissa Barthem

Laboratorietekniker Institutionen för molekylär biovetenskap, Wenner-Gren Institutet (MBW) är en av de största institutionerna vid Naturvetenskapliga fakulteten vid Stockholms universitet med mer än 30 forskargruppe

Great opportunity for a Laboratory technician!

The Jastroch Lab at the Department of Molecular Biosciences, Wenner-Gren Institute (MBW), Stockholm University, is looking for a motivated lab technician to join the team.

su.varbi.com/what:job/job...

Mechanisms and therapeutic insights into MASH-associated fibrosis Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease posing a major global health concern, closely related to the rising prevalence of obesity. Liver fibrosis is the ...

"Mechanisms and therapeutic insights into MASH-associated fibrosis"

www.cell.com/trends/endoc...

Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes - Nature Medicine Multimodal data from 347 deeply phenotyped individuals including healthy, prediabetic individuals and individuals with T2D report remotely acquired patterns of glucose control via continuous glucose m...

"Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes"

www.nature.com/articles/s41...

How to thrive as a Latin American researcher abroad Four scientists share the emotional toll of pursuing science far from home — and the strategies that help them to protect their mental health.

www.nature.com/articles/d41...

The multifaceted regulation of white adipose tissue browning and their therapeutic potential - Journal of Physiology and Biochemistry Adipose tissue browning, the conversion of white adipose tissue (WAT) into brown or beige adipose tissue, offers potential for combating obesity and metabolic disorders. This review delves in to the t...

"The multifaceted regulation of white adipose tissue browning and their therapeutic potential"

link.springer.com/article/10.1...

GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice - Nature Metabolism This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, exp...

RESEARCH | 🧪
‪C Liu, M Véniant, @danieljdrucker.bsky.social et al‬‬‬
@amgen.bsky.social @sinaihealth.bsky.social ‪

Part 1: This study and a co-pub delve into how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

www.nature.com/articles/s42...

GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity Design of compounds with divergent signaling reveals GRK2-biased β2AR agonists that demonstrate efficacy and safety in preclinical models of metabolic disease and are well tolerated in a phase 1 clini...

"GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity"

www.cell.com/cell/fulltex...

Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.

"Cysteine depletion triggers adipose tissue thermogenesis and weight loss"

www.nature.com/articles/s42...

Mitochondrial Bioenergetics in Physiology Click on the article title to read more.

DID YOU KNOW - "Mitochondrial Bioenergetics in Physiology"

onlinelibrary.wiley.com/doi/10.1111/...

Next Adipose Biology Seminar Series with Dr. Cayleih Robertson, Ph.D.

"A distal enhancer with ETV4 binding is critical for UCP1 expression and thermogenesis in brown fat"

genesdev.cshlp.org/content/earl...

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice Nature Metabolism, Published online: 29 April 2025; doi:10.1038/s42255-025-01294-xThis study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

ICYMI:

Microscopy setup protocols A collection of Protocols and Tutorials covering a range of microscopy approaches, and including the build of microscopy setups and the use of microscopy ...

Today we share our Collection on protocols describing how to build and operate a broad variety of microscopy setups.

Let us know which one is your favourite microscope?

🧪 🔬

Older people with type 1 diabetes mellitus: a call for a new management approach Nature Reviews Endocrinology, Published online: 14 April 2025; doi:10.1038/s41574-025-01118-8The growing population of older adults with type 1 diabetes mellitus presents unique challenges, including frailty, comorbidities and polypharmacy. A holistic multidisciplinary approach is crucial to address this population’s complex needs, improve care delivery, and ensure their independence and quality of life amid the realities of ageing with this lifelong condition.

New content online: Older people with type 1 diabetes mellitus: a call for a new management approach

Islet hormones at the intersection of glucose and amino acid metabolism Nature Reviews Endocrinology, Published online: 07 March 2025; doi:10.1038/s41574-025-01100-4This Review discusses how levels of glucose, amino acids and lipids influence islet hormone secretion. The authors also discuss how crosstalk between α-cells,…

New content online: Islet hormones at the intersection of glucose and amino acid metabolism

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation - Nature Metabolism Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.

RESEARCH | AM Casey, MP Murphy et al. (U Cambridge):

The study explores the basic mechanisms of superoxide production in #mitochondria and its impact on interleukin-1β production in LPS-treated macrophages ✨ 🧫

The Physiology of Obesity: From Mechanisms to Medicine The Physiology of Obesity: From Mechanisms to Medicine 2025 is the first in-person Physiology M2M conference which will explore diverse topics in the field of obesity.

📢 Submit your abstract to shape the future of #obesity research!

Abstracts can be submitted as either oral or poster communications for your chance to showcase your research at our meeting 'Physiology of Obesity' on 8 – 9 July at University of Nottingham.

📆 Submit your abstract by 30 April ⬇️

Control of circadian muscle glucose metabolism through the BMAL1–HIF axis in obesity | PNAS Disruptions of circadian rhythms are widespread in modern society and lead to accelerated and worsened symptoms of metabolic syndrome. In healthy m...

During diet-induced #obesity in mice, skeletal muscle BMAL1 is an important regulator of HIF-driven glycolysis and metabolic flexibility, which influences the development of high-fat-diet-induced glucose intolerance @pnas.org www.pnas.org/doi/10.1073/...

Mark Burnley of @lborouniversity.bsky.social et al. present this #TopicalReview reflecting on the relevance of A.V. Hill's work into the physiology of intense exercise 100 years later✍️ 📚

🔗 Read it here: buff.ly/U43wAXN

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

The importance of considering time of day for metabolic experiments

www.nature.com/articles/s42...

Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice - Acta Pharmacologica Sinica Acta Pharmacologica Sinica - Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice

In high #fat #diet fed mouse females Semaglutide regulates oocyte reactive oxygen species production and ameliorates metabolic syndrome in the offspring #DOHaD @dohadcanada.bsky.social
www.nature.com/articles/s41...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

"Lactate homeostasis is maintained through regulation of glycolysis and lipolysis"

www.cell.com/cell-metabol...

A cellular and molecular basis of leptin resistance Tan and Hedbacker report that rapamycin, an mTOR inhibitor, reduces food intake and fat mass in diet-induced obese mice but not in leptin-deficient animals. Increased mTOR activity in POMC neurons cau...

"A cellular and molecular basis of leptin resistance"

www.cell.com/cell-metabol...

Unveiling adipose populations linked to metabolic health in obesity Metabolic disease risk in individuals with obesity is variable and influenced by so-far-unknown factors. Reinisch and Ghosh et al. uncovered distinct cell populations and transcriptional programs in a...

"Unveiling adipose populations linked to metabolic health in obesity"

www.cell.com/cell-metabol...

Metabolic Messengers: small extracellular vesicles - Nature Metabolism Olefsky, Rohm and Cunha e Rocha provide a concise overview of the role of small extracellular vesicles in metabolic health and discuss their history, role as biomarkers, mechanisms of action and thera...

METABOLIC MESSENGER | Jerrold Olefsky, Theresa Rohm and Karina Cunha e Rocha (UCSD)

Overview of the role of small #ExtracellularVesicles (#EVs) in #metabolic health, role as #biomarkers, #mechanisms of action and #therapeutic potential.

www.nature.com/articles/s42...

@ucsdmedschool.bsky.social

Today is #WorldObesityDay!

Almost 6/10 adults and nearly 1/3 children in Europe live with obesity or are overweight. It is time to challenge stigma and recognise the need for systems to change - not people.

Find out more 👉 www.worldobesityday.org
#BecauseHormonesMatter

Adenylate cyclase 10 promotes brown adipose tissue thermogenesis Brown adipose tissue (BAT) thermogenesis dissipates energy through heat production and thereby it opposes metabolic disease. It is mediated by mitocho…

"Adenylate cyclase 10 promotes brown adipose tissue thermogenesis"

www.sciencedirect.com/science/arti...

Nothing in life is to be feared, it is only to be understood. Marie Curie, Physicist and chemist.

Today is International Day of Women & Girls in Science.

Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM