Palmitoyl Acyltransferases Control the Membrane Localization of DNAJC5 to Regulate Unconventional Protein Secretion Acylation of DNAJC5 by PAT facilitates its association with the Golgi apparatus, enhancing the secretion of abnormal cytosolic proteins via unconventional protein secretion.

Palmitoyl Acyltransferases Control the Membrane Localization of DNAJC5 to Regulate Unconventional Protein Secretion
onlinelibrary.wiley.com/doi/10.1111/...

Exploring placental ultrastructure: A review of electron microscopy techniques and emerging methods for resolving 3D organelle architecture - PubMed Trophoblast cells line the surface of placental villi, facilitating the exchange of nutrients, gases, and wastes between the maternal and fetal circulations. The fusion of cytotrophoblast (CTB) cells into the surrounding multinucleated syncytiotrophoblast (STB), is accompanied by a shift in cellular …

New issue of the #PlacentalCellBio reports by
@biomednews.bsky.social

biomed.news/bims-placeb/...

My fav pick is this comprehensive review on the evolution of the study of the ultrastructure of the placenta using EM <3

Heterogeneity, dynamics and organelle interactions of lipid droplets - Nature Reviews Molecular Cell Biology Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...

With so many great reviews on LDs already out, do we need another?

Sarah @cohenlaboratory.bsky.social and I were approached by
@natrevmcb.nature.com to do a review on LD heterogeneity and inter-organelle contacts...topics in reviews, but not a focus. Fun project!
www.nature.com/articles/s41...

Thanksgiving edition of the publications in the #PlacentalCellBio section of @biomednews.bsky.social

biomed.news/bims-placeb/...

Cheers!

Lipid Droplet Remodeling Safeguards Redox Balance through the DGAT1-PANK2-NRF2 Axis in Mammalian Oocytes and Drives Age-Associated Decline https://www.biorxiv.org/content/10.1101/2025.11.28.691261v1

Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Our latest review is now online! 👇

@martenslab.bsky.social

Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair www.biorxiv.org/content/10.1...

text "Core Facility Technology Talks 2025 A UNC Chapel Hill 2025 Research Week Event UNC Chapel Hill core facilities provide centralized access to expertise, technology, and instrumentation. New services and equipment are added every year. These technology talks, held during the 2025 UNC Research Week, will highlight some of the new capabilities of our core facilities" green and blue image of cells

UNC Core Facility Technology Talks
Monday, October 20, 2025 | 1 - 4 PM
Join us in 3112 Mary Ellen Jones building or virtually.

@oor-unc.bsky.social
www.med.unc.edu/corefaciliti...

Remembering Primatologist Jane Goodall Trailblazing chimp researcher and conservationist Jane Goodall died on October 1 at 91.

In memory of Dr. Jane Goodall, we're releasing a special podcast episode today. Ira Flatow shares his memories of the renowned primatologist, including a 2002 interview in which they discussed her groundbreaking discoveries and hopes for a better future.

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C VPS13A and VPS13C are bridge-like lipid transport proteins with distinct subcellular localization and function, and their absence is linked with chorea-acanthocytosis and Parkinson's disease, respecti...

"Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C" out now in PLOS Biology
journals.plos.org/plosbiology/...

Molecular basis of polyadenylated RNA fate determination in the nucleus Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis - Nature A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes...

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com/articles/s41...

Efficient stem cell-derived mouse embryo models for environmental studies - PubMed Blastoids are stem cell-derived structures that mimic natural blastocysts by incorporating all three lineages: trophectoderm, epiblast, and primitive endoderm. However, current methods often yield inc...

Here are the curated lists of pubs in the #PlacentalCellBio
@biomednews.bsky.social report from the last two weeks!

biomed.news/bims-placeb/...
biomed.news/bims-placeb/...

My personal choice: this resource from the Zernicka-Goetz's lab! pubmed.ncbi.nlm.nih.gov/40882624/

Enjoy!

Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...

Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!

Differential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines https://www.biorxiv.org/content/10.1101/2025.08.26.672484v1

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Autophagy: Mechanisms to Therapy | Keystone Symposia Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!

Working with a great team to organize @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February! Join us to explore emerging research in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26

The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions Macroautophagy, a major self-degradation pathway in eukaryotic cells, utilizes autophagosomes to transport self-material to lysosomes for degradation. While microtubular transport is crucial for the p...

www.biorxiv.org/content/10.1...

How PFAS From A Military Base Has Sickened Nearby Residents Newburgh, New York, is one of 10 communities involved in a CDC-led study to understand the effects of PFAS—forever chemicals—on health.

Toxic PFAS from firefighting foam contaminated a town’s water supply for decades. Now, early data from a CDC-led study is illuminating the forever chemicals’ effects on its residents.

Check out this fantastic Review from the @charlyguardia.bsky.social lab!!

Very interesting!!!!!

Guardia Studies Role of Environmental Stressors on Fetal Development NIH's Dr. Carlos Guardia studies the placenta. He and his team strive to understand the effects of maternal obesity and other environmental stressors on the future health of the baby.

A little glimpse into our lab at NIEHS/NIH! 👋🏽

Activation of lysosomal iron triggers ferroptosis in cancer - Nature Some cancer cells exhibit high loads of reactive&nbsp;iron in lysosomes, and this feature is exploited by&nbsp;using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

new out in Nature, very cool story www.nature.com/articles/s41...

Structural basis of lipid transfer by a bridge-like lipid-transfer protein pubmed.ncbi.nlm.nih.gov/40269155/ #cryoEM

Mouse egg cells stash endosomes, lysosomes, and autophagy regulators in giant structures called ELYSAs. After fertilisation, they break down, timing the embryo’s cleanup and recycling systems for early development.
buff.ly/aM5oMxt