International Journal of Neuropsychopharmacology

By integrating personality dimensions into diagnostic evaluation, the study opens new perspectives for refining classification and advancing personalized treatment strategies in psychiatry.

Check the paper to find more: doi.org/10.1093/ijnp...

In this month’s Editor’s Pick, Hashimoto et al. deliver an insightful meta-analysis comparing personality profiles in schizophrenia & bipolar disorder.

This reinforces that lithium modulates unique metabolic mechanisms. However, predicting who will respond remains a complex challenge that has not yet been solved by blood metabolomics.

Read more here: doi.org/10.1093/ijnp...

#BipolarDisorder #Psychiatry #Lithium #MoodStabilizers

A new study investigated this by analyzing the blood metabolome of BD patients
✅ Lithium & other MS have different metabolic signatures in pathways involving glucose, pyruvate and glutamate metabolism
❌ The study found no significant differences between responders and non-responders
#Metabolomics

💊Lithium vs. Other Mood Stabilizers: Distinct Metabolic Signatures in #Bipolar Disorder (BP)

BD is primarily treated with mood stabilizers (MS): lithium represents the gold standard.
Despite its high clinical efficacy, the molecular players in treatment response remain partly unclear👇
#MedEd

Anhedonia is associated with a specific depression profile and poor antidepressant response AbstractBackground. Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonrespons

These findings argue for the assessment of anhedonia in clinical practice to better guide treatment management

Read+: doi.org/10.1093/ijnp...

Anhedonia is associated with a specific depression profile and poor antidepressant response AbstractBackground. Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonrespons

💊Findings reveal a treatment-resistance profile for the anhedonic #MDD. Data suggests #SSRIs may be less effective to non-anhedonic MDD, supporting the need for targeted, non-5HT therapeutic strategies

🦋 The MDD profile was related to specific somatic comorbidities, notably thyroid dysfunction and Type 2 Diabetes Mellitus #T2DM. The link highlights the possible role of disruption in reward circuitry and endocrine function.

New Study Alert: Anhedonia in MDD - Clinical Correlates & Treatment Response🧠
🚨New research published in IJNP confirms anhedonia (MADRS item 8 – inability to feel) as a key marker for severe MDD course.

Symposium Submission - Glasgow CINP2026 Symposia shall be of 75 minutes duration, and shall include three speakers, one of whom can, if desired, be the chairperson of the session.

🚨Call for Symposia – CINP 2026, Glasgow🚨

Be part of shaping the scientific programme at one of Europe’s most vibrant cities!🌍✨

📅Deadline: 7th October 2025
💡30 symposia slots available – don’t miss this chance!

cinp2026.org/submissions/...

#cinp #neuropsychopharmacology

📣Join CINP + BJPsych joint journal club to discuss the future of academic psychiatry with Prof Allan Young and experts!

The role of affective states in computational psychiatry Abstract. Studying psychiatric illness has often been limited by difficulties in connecting symptoms and behavior to neurobiology. Computational psychiatry

💡By showing how emotions and moods influence decision-making and symptom development, this paper highlights a path toward AI-driven tools that can better explain and treat psychiatric disorders
🔗Read the Editor’s Pick doi.org/10.1093/ijnp...
#ComputationalPsychiatry #MentalHealth #DigitalPsychiatry

🧠🤖Affective states as clinical signals: AI models for decision-making and symptoms

This month’s Editor’s Pick examines the role of affective states in computational psychiatry—a field that uses mathematical and AI-based models to link behavior, brain function, and mental health.

📢Exciting news #CINP2026 in Glasgow will be a Joint Meeting of the Scandinavian College of Neuropsychopharmacology +the International College of Neuropsychopharmacology!
Join us for this unique event which promises to be an outstanding meeting of science &collaboration
@actaneuropsych.bsky.social

Read more: doi.org/10.1093/ijnp...

#AlcoholUseDisorder #Hippocampus #Neurogenesis #AddictionResearch

In preclin model, adolescent ethanol exposure set the stage for later harm: adult voluntary ethanol intake further impaired neurogenesis🧭

⚧️Effects seen in both sexes!
🔬NeuroD, an underexplored marker of early neuronal survival, emerged as a sensitive biomarker of this ethanol-induced neurotoxicity

🧠🍷Neurogenesis, Ethanol & biomarker

It is known that excessive ethanol disrupts hippocampal structure/function, especially with adolescent onset. But how does neurogenesis plays out in this context?

Stress-Induced Altered Expression of Hippocampal Nuclear and Mitochondrial Encoded Genes in Rats and Cross-Species Genetic Associations Reveal Molecular Links to Depression AbstractBackground. Mitochondria play a pivotal role in energy production, and their dysfunction not only hampers cells' ability to meet energy requirement

Check the paper to see how it uncovered insights into: doi.org/10.1093/ijnp...
✨How mitochondria adapt to stress
🔄The regulatory landscape governing mitochondrial function & cellular resilience
🌀Biological pathways relevant to stress-related disorders

🔬MitoGenes
🧬Mitochondrial and nuclear-encoded genes were differentially regulated and co-expressed in stressed rats
🔗Cross-species analysis uncovered functional genetic associations in humans.
Notably, SNPs rs1573529 and rs10899570 showed significant associations w/depressive behavior

⚡Beyond the Powerhouse: Mitochondria, Genes, and Depression in a Cross-Species Study
🧠🔋When mitochondrial function falters, the brain struggles to meet energy demands, contributing to the impaired plasticity observed in MDD.
#Mitochondria #Depression

Volume 28 Issue Supplement_2 | International Journal of Neuropsychopharmacology | Oxford Academic The official journal of Collegium Internationale Neuro-Psychopharmacologicum. Publishes papers that advance understanding of existing and new neuropsychopharmacological agents or provide insights into...

We are delighted to announce that the abstracts from CINP-AsCNP 2025 Joint Congress in Melbourne have been published as a Supplement to the International Journal of Neuropsychopharmacology

Read the abstracts here:
academic.oup.com/ijnp/issue/2...

Predicting antidepressant responsiveness in major depressive disorder patients via electroencephalography gamma-band dynamic functional connectivity in response to salient auditory stimuli Significance Statement Predicting antidepressant responsiveness in patients with major depressive disorder (MDD) remains a clinical challenge due to their

🔹 Personalized Psychiatry
EEG could become a practical tool in depression care, guiding treatment choices earlier and helping decide whether standard antidepressants are the right path or if alternative approaches should be considered.

Check the paper: doi.org/10.1093/ijnp...

🔹 Machine Learning Prediction
Even before treatment begins, dynamic EEG patterns can help identify patients less likely to respond

#Psychopharmacology
#PrecisionMedicine

Is it possible to predict antidepressant response?
📌 Check the Editor’s July Pick in #IJNP
This recent study investigated whether brain activity patterns (EEG) could help predict which patients with depression may respond to antidepressants (#vortioxetine or #escitalopram).

Five-factor personality traits in patients with schizophrenia and bipolar disorder: A systematic review and meta-analysis AbstractBackground. Personality traits play crucial roles in the onset, manifestation, and course of schizophrenia and bipolar disorder (BD). Previous meta

🧠 Implications:
Neuropharmacology: Could trait-specific profiles guide personalized treatments?
Early Detection: High Neuroticism + low Extraversion could be potential risk markers?

Check the paper: doi.org/10.1093/ijnp...
#Schizophrenia #BipolarDisorder #BigFive #PersonalizedMedicine

The Five-Factor Model highlights how these traits intersect with psychiatric conditions, offering clues for pathogenesis and tailored interventions.

📊 Key Findings:
SCZ vs. Controls: Lower extraversion, openness, agreeableness.
SCZ vs. BD: SCZ shows more marked deficits in E, O, A

🔬 Personality Traits in Schizophrenia vs. Bipolar Disorder
Personality traits play pivotal roles in the onset, manifestation, and progression of schizophrenia (SCZ) and bipolar disorder (BD).

Association between anhedonia severity and clinical, humanistic, and economic outcomes among US adults with major depressive disorder Significance Statement In this study, we examined the relationship between anhedonia (lack of interest, enjoyment or pleasure from life’s experiences), whi

- Anhedonia signals a greater clinical, humanistic, and economic burden.

- Targeted treatments for MDD patients with prominent anhedonia could improve symptoms, quality of life, and work productivity.

Check the paper for + info: doi.org/10.1093/ijnp...

#Anhedonia #MDD #Psychiatry #MentalHealth

🚨 Worse depression & anxiety severity

📉 Lower quality of life

💼 Greater work & daily activity impairment

💰 Higher medical costs

What psychiatrists & healthcare professionals should take into consideration:

🧠 More Than Mood: Anhedonia as a Public Health & Economic Issue

How one symptom can ripple through mental health, productivity, and the healthcare system.

In a large US study of ~75,000 adults (≥18 years) with depression, higher anhedonia was tied to: