Michael Kasten

Whoa.

I guess she’d aged out. But still seems to fit a certain pattern.

I have figs I actually paid money for…

Pizza. Prosciutto, goat cheese, figs, hot honey.

Tried it for a few months, then moved to Bing. Not ideal. I want 2002 Google…

I’m very sorry for your loss.

WTAF.

A major NIH grant to study ways to restore hearing was terminated by the Trump administration bc it was awarded through a DEI initiative—to a researcher who qualified bc of his own hearing loss www.cnn.com/2025/07/29/h... @manorlaboratory.bsky.social

I find it absolutely infuriating that this moron is in charge of $$$. That he can get on TV and make outrageously false claims like “NIH funded the gain of function research that caused pandemic” without a hint of pushback???

You know what would be perfect with this?? 10 hams.

a cartoon of homer simpson sitting in a theater holding a box of nachos Alt: a cartoon of homer simpson sitting in a stadium seat singing “nacho nacho man!”

UNC people know what Friday means..

My dad’s favorite anecdote about me was that when I was 4, he heard screaming and ran outside to find me dangling by my teeth from the thumb of a 6th grader while another was holding his bleeding hand. They had had tried to take my big wheel. This is the energy with which I try to meet every day.

Dear fellow academics, is there anyone out there pushing ahead fueled by anything besides spite? What would that even look like??

a young boy is driving a red toy car down the street . Alt: SOO FAST (drifitng kiddiecar GIF)

For the ephys weirdos (like me), note the speed of these neurons - most cells can fire at 500+ Hz for an entire second, have AP half-widths of <200 us, and are just silly fast. But to foreshadow (I hope) - they may not be the biggest or fastest neurons in the auditory system.

Very pleased to have this out, major kudos to Reggie, Ken Hutson (for the beautiful light sheet images), Malcolm Lutz (histological reconstruction), and Paul Manis (all the things). 6/6

Histologically, these neurons demonstrated pruning of basal dendrites following the onset of hearing, with an increase in the oldest group, suggesting remodeling with the onset of age related hearing loss. 5/6

We didn't work out the specific channels underlying these changes (voltage clamp in these large, fragile neurons is very challenging), but we did see an increase in the rate of repolarization, suggesting a possible increase in potassium channels (Kv3s?). 4/6

Electrophysiologically, these neurons are largely stable through the first year, but at >p550 (roughly ~55-65 years in humans), where we start to see significant changes in auditory threshold/magnitude and structural changes in the cochlea, fusiform neurons speed up! 3/6

These are large, fragile auditory brainstem neurons that receive both direct and indirect auditory input and sensorimotor feedback. Previously, these neurons have been examined during development (p4-p21), but I believe this is the first examination of these neurons after ~p35 in mouse. 2/6

PREPRINT FUN!! Led by our soon-to-be PhinisheD graduate student Reginald Edwards, we looked at the electrophysiological and histological properties of dorsal cochlear nucleus fusiform neurons (principal output neurons) with age, from p15 up to p578 in CBA/CaJ mice (mice with normal hearing). 1/6

Where’s my hams, Tom???

My father was involved in engineering this in the 1980s/1990s, at the time a farmer had to install hardware to improve localization because GPS was limited to ~300’. But it was clear that the future was detection of pests, water, soil quality to direct seed density and fertilizer. Cool stuff!

Those blonde highlights have you mad with power. I am here for it.

Keep it to yourself. I don’t want to know Gen Z slang, thoughts, or kinks, plz.

Signed,
An Old

Did you bring iberico???

For everyone who grew up around there, this is largely a due to "precision farming". Back in the day, the edges and corners were very stunted, now seed density and fertilizer are adjusted so all the plants receive similar conditions. #couldabeenthirdgenJohnDeereemployee

For all the grief with give Leica (which I stand behind), I think we’ve failed to take Axon to task for just how much they suck.

Your Grammy, sir..

entertainment.ha.com/itm/music-me...

Lolol. I think all the Catholic school teachers I had in HS would JUMP at this. They got no benefits and 1/2 the salary.

I have two moles on the back of my neck and my youngest was not happy that he couldn’t pull them out, but never gave up trying.