Takaku Lab

+++ Postdoc Opportunity +++
My lab is looking for researchers interested in combining cutting edge #genomics, #epigenetics and #AI for precision oncology in pediatric #leukemia.
www.dkfz.de/fileadmin/us...

Applications via the #DKFZ postdoc program:
www.dkfz.de/en/karriere/...

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

Structural basis of the hepatitis B virus X protein in complex with DDB1 | PNAS A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this appr...

Structural basis of the hepatitis B virus X protein in complex with DDB1 | PNAS www.pnas.org/doi/10.1073/...

RNA transcripts regulate G-quadruplex landscapes through G-loop formation G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...

Pioneering new enhancers by GATA3: role of facilitating transcription factors and chromatin remodeling Abstract. Pioneer transcription factors (PTFs) bind to inaccessible chromatin and recruit collaborating transcription factors to promote chromatin accessib

Congrats on the new paper to Krystal who "doesn't do social media" but does do a ton of ATAC and Cut&Run to show how GATA3 pioneers enhancers with BRG1 and sometimes AP-1! #NIEHS #NAR doi.org/10.1093/nar/...

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social

Our second cell-free DNA manuscript is here! In collaboration with Dr. Takada’s group, we explore how abemaciclib treatment response in metastatic breast cancer can be monitored via circulating chromatin fragments: www.researchsquare.com/article/rs-5...

🚀Excited to share preprint as my last work in the Tachibana lab! Our study shows how the pioneer factor NR5A2 ensures robust gene activation through feed-forward regulatory loops with lineage-determining factors. A quick summary follows (1/n)
www.biorxiv.org/content/10.1...

🚨Amidst all the uncertainty at NIH Welcome Leap just launched an important new $50M program in Women’s Health👩🏻‍🔬🧠

CARE focuses on the link between Alzheimer’s and perimenopausal hormonal changes wellcomeleap.org/care/

Note: full indirects!

Please share widely to support women’s health 🙏🏼

Excited to share our first preprint on cell-free DNA! Led by our talented grad student Sakuntha, we have developed a machine learning pipeline guided by ATAC-seq to identify unique nucleosomal fragment patterns in cancer patients. www.researchsquare.com/article/rs-5...