@davidlleres.bsky.social
CNRS researcher in Marcelo Nollmann's team at Centre de Biologie Structurale (CBS) in Montpellier, France. Microscopist interested in using advanced imaging techniques (Hi-M, FRET, etc) to study 3D genome organization, gene regulation and epigenetics.
Excited to share our new preprint on Myxococcus xanthus!
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
15.10.2025 12:22 — 👍 493 🔁 185 💬 56 📌 61Amazing !! I tried earlier version and it was impressive ! Congrats !
15.10.2025 19:38 — 👍 3 🔁 1 💬 1 📌 0
En ce début d’automne 2025, le CNRS continue de mettre à l’honneur les #FemmesEnScience. Tandis que "La Science taille XX elles" lance sa 8e édition, CNRS Ingénierie inaugure avec "Ingénieuses" une nouvelle exposition itinérante. Et le 15/10 paraît "Les filles sont parfaites pour les sciences".
14.10.2025 05:02 — 👍 58 🔁 28 💬 0 📌 2Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Fly labs — Now is the time to show some solidarity and chip in support for this vital resource!
20.08.2025 01:53 — 👍 48 🔁 39 💬 1 📌 1
How do enhancer-gene contacts relate to transcription activation? In mouse embryonic stem cells, a combo of STED, oligoFISH & RNA FISH shows that 3% of Dppa3 alleles transcribe. For these, enhancers and promoters come closer (panel E). Stumberger ... Leonhardt & Harz www.biorxiv.org/content/10.1...
26.07.2025 21:36 — 👍 66 🔁 31 💬 1 📌 0🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!
20.05.2025 10:20 — 👍 12 🔁 13 💬 0 📌 0
05.05.2025 10:52 — 👍 2157 🔁 798 💬 15 📌 37
You can read about TurboCas here: www.sciencedirect.com/science/arti....
29.04.2025 20:24 — 👍 13 🔁 3 💬 1 📌 0
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
36 slots for selected talks from abstracts! Join us and share your latest research!
Deadline for early registration coming up next week
Come start your lab in beautiful Strasbourg 🇫🇷 www.nature.com/naturecareer...
22.03.2025 13:50 — 👍 35 🔁 29 💬 1 📌 0
Excellent keynote lecture by Susan Gasser at EpiGene3Sys @institutcurie.bsky.social.
A summary of ground-breaking work on the role of H3K9 methylation in restricting access of activators to chromatin.
In addition Susan has a track record as excellent mentor.
'People is all what it is about.'
The U.S. Department of Defense is ending all of its funding for social science research, stopping 91 ongoing studies related to threats such as climate change, extremism, and disinformation. scim.ag/4hqu6HA
10.03.2025 20:50 — 👍 464 🔁 374 💬 22 📌 40Our study on how TAD boundaries actively influence the neighboring domains published today in @pnas.org: www.pnas.org/doi/10.1073/...
Exciting outcomes from this interdisciplinary genomics/biophysical modeling strategy. See the thread for the BioRxiv preprint for a summary of highlights.
#Enhancer folks, submit your abstracts and register soon! Deadlines are around the corner and there are many opportunities for short talks.
26.02.2025 06:23 — 👍 8 🔁 8 💬 0 📌 0
Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'
Lots of interesting new TE (& genes) biology
Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/
We highlighted new research from the past two years on examples of long-range gene regulation - within large TADs, across TADs, and across chromosomes - comparing mechanisms in flies and mammals 🪰❤️🐁.
www.sciencedirect.com/science/arti...
Un amendement pour pomper 100 millions d'euros sur la trésorerie (fonds de roulement) du #CNRS qui, c'est bien connu, roule sur l'or #ESR #budget2025
www.publicsenat.fr/actualites/e...
Excited to share James Jusuf's preprint:
By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)
We quantify mESC 36k loops: <loops> are generally rare (2.3%)
www.biorxiv.org/content/10.1...
L’Institut Pasteur décide de quitter X (ex-Twitter) pour rejoindre BlueSky ! 🦋
L’Institut Pasteur a pris cette décision en raison de plusieurs dérives graves constatées sur la plateforme X depuis son rachat. Rejoignez-nous pour continuer à défendre la science ! www.pasteur.fr/fr/espace-pr...
Highly recommended (I am co-organizing this exciting meeting)! Please come and join us!
14.01.2025 13:08 — 👍 13 🔁 5 💬 0 📌 0Registration deadline extended!
13.01.2025 08:40 — 👍 2 🔁 1 💬 0 📌 0
Out now in
@ScienceAdvances
👇 science.org/doi/10.1126/... BRAVO @tomsexton_lab and super help from @tinekelenstra.bsky.social
@mitchell_lab @akispapantonis.bsky.social
@molina_lab @evisoutoglou.bsky.social @NeoVirTech
Présente à la convention des labos du CNRS, la seconde après celle de 2019
Antoine Petit annonce un nouveau label pour concentrer les efforts dans 25% des unités : les keylabs
La liste des labos est en finalisation, on vous en reparle bientôt dans @themeta.news
#VeilleESR
😱📣 BlueSky-ers: WE NEED YOUR HELP!!! 🙏
All of you who ever liked a lecture of mine...
All of you who liked one of the courses I teach in...
All of you I work(ed) with in one way or another...
All of you who see my desperation! 😜
PLEASE re-post! 🙏 careers.humantechnopole.it/o/postdoc-in...
