Melissa Call

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗

🦟 Transgenic parasites without Pfs230 D13D14 do not transmit

🦙 💉Nanobodies + mRNA induced antibodies reduce transmission

New in @Science.org

www.science.org/doi/10.1126/...

#ScienceResearch #Malaria #WEHI

*misfolding

The battle of the decades is complete. Thank you Leann Tilley for the excellent chairing and all the speakers for a fun session. @lorneproteins.bsky.social

James Whisstock takes us to the present day highlighting some of the coolest techniques presented at #Lorneproteins in the past decade.

A Protein structure was not enough to get a talk by the early-mid 2000s (unless it was a membrane protein :-) ) Jacqui Matthews @lorneproteins.bsky.social

Protein missing is pretty important - Robin Anders @lorneproteins.bsky.social

Marilyn Anderson reminisces on the beginning of Protein design in the late 80s #Lorneproteins @lorneproteins.bsky.social

Lindsay Sparrow tells us there was only 23 structures in the PDB when #Lorneproteins started in 1976! @lorneproteins.bsky.social

Congratulations Frances Separovic on winning the Leach Medal - #lorneproteins

Deb Leach sharing her thoughts on her father, Syd Leach, who started #Lorneproteins

The 50th Lorne Conference on Protein Structure and Function - Beautiful Welcome to Country #lorneproteins

Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy https://www.biorxiv.org/content/10.1101/2024.12.22.629940v1

Fig. 1 Overview of model and architecture. a) Actin conformational changes and filament formation / dissociation as an example for the mechanistic basis of protein function. b) ML model architecture consisting of protein sequence encoder and denoising diffusion model. The diffusion model samples coarse-grained protein structures from an approximate equilibrium distribution, from which properties such as free energy differences can be computed. c) Architecture of the score model used in the denoising diffusion model. d) Data integration and model training pipeline. e) Data processing pipeline for pretraining. f) Experimental property training for finetuning

Scalable emulation of protein equilibrium ensembles with
generative deep learning www.biorxiv.org/content/10.1...

No code is available yet, but sounds huge. Effectively does MD-sim, but fast!

ICYMI: this really interesting @science.org paper on possible underlying mechanisms of post-accute #COVID19 syndrome ( #PACS ) aka " #LongCOVID" from last January!

A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells - Nature Communications Context-dependent, responsive synthetic promoters are crucial for a wide range of applications, yet currently available options are limited. Here, authors develop a library of thousands of candidate p...

A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells

www.nature.com/articles/s41...

De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1 Chimeric antigen receptors (CAR) that mimic T cell receptors (TCR) on eliciting peptide-major histoc

De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries https://www.biorxiv.org/content/10.1101/2024.11.27.625413v1

Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1 Background: Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment landscape o

Development of antigen-dextramers for detection and evaluation of CAR T cells https://www.biorxiv.org/content/10.1101/2024.11.27.625576v1

Diffusion of pMHC binders

Design of high specificity binders for peptide-MHC-I complexes www.biorxiv.org/content/10.1...

New from the Baker lab

A major step forward toward high-resolution nanopore sequencing of full-length proteins In a recent publication in Nature, Motone et al. report the development of a protein sequencing method using nanopores that enables the reading of long protein strands. This method allows for multi-pa...

A major step forward toward high-resolution nanopore sequencing of full-length proteins www.cell.com/molecular-ce...

C/O the #adelaideproteingroup The Lorne Proteins Conference 2025 is coming up! Feb 9–13, 2025, it’s a must for protein science enthusiasts.
🇦🇺 Lorne, Victoria
💡 Connect with international experts, share your research, and explore the latest advancements.
📅 Register now: lorneproteins.org