Joe Rogers

New Danish research centre to make designed proteins with vast potential - Novo Nordisk Fonden

New €94M research centre for protein design will open at the University of Copenhagen and be led by Dek Woolfson

Funded by the Novo Nordisk Foundation, the centre will operate across the Departments of Biology and & Drug Design and Pharmacology

novonordiskfonden.dk/en/news/new-...

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!

rdcu.be/eq975

Small proteins can be more complex than they look!

We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!

Stellar line up for our protein design conference. Copenhagen, Sept 1-4, 2025. 10 days to abstract deadline. Get applying! benzon-foundation.dk/benzon-sympo...

Nonopioid drug for acute pain wins FDA approval Ongoing trials will reveal whether suzetrigine is also effective against chronic pain

A long-awaited nonopioid pain drug has won approval from the U.S. Food and Drug Administration (FDA) to treat moderate to severe short-term pain.

The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution

Thanks for coming to my TED talk

How to make a presentation? Don't save the best for last! Right from the start, describe your main question and a summary of your big idea. Everyone is listening at those first few minutes but they'll only continue to listen if you grab their attention.

PhD fellowship in Chemical Microbiology at Department of Drug Design and Pharmacology Faculty of Health and Medical Sciences, University of Copenhagen We are offering a three-year PhD fellowship in Chemical Microbiology commencing 1 May 2025

We have an exciting PhD position available. In collaboration with researchers @scripps.edu, we will investigate bacterial communication within the gut microbiome for potential health benefits, using chemical tools.

Deadline 9 February, see 👇

candidate.hr-manager.net/ApplicationI...

Come to Copenhagen

Figure from the paper that illustrates the approach of probing the transition state for amyloid growth by experiments and simulations

How do proteins mis-fold?

Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with MD simulations to study the transition state for amyloid fibril growth

doi.org/10.1038/s415...

🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍

I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.

PhD opportunities (yes, plural!)

We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism.

- Details and application link: tinyurl.com/44hf9zkd
Please repost 💚

Thanks also to @lindorfflarsen.bsky.social and @sobuelow.bsky.social for invaluable insights and simulations

Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins The formation of biomolecular condensates is involved in compartmentalisation, regulation, and signalling across most living organisms. Condensation can be driven by phase separation of proteins, and ...

mRNA display continues to astound. Fantastic collaboration with Alex Buell, led by the peerless @rasmusnorrild.bsky.social. ~100,000 peptides and their propensity to join the phase separation of a model disordered protein. doi.org/10.1101/2024...

‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk

Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins https://www.biorxiv.org/content/10.1101/2024.12.21.629870v1

A Versatile “Synthesis Tag” (SynTag) for the Chemical Synthesis of Aggregating Peptides and Proteins Solid-phase peptide synthesis (SPPS) and native chemical ligation (NCL) are powerful methods for obtaining peptides and proteins that are otherwise inaccessible. Nonetheless, numerous sequences are di...

Our Synthesis Tag (SynTag) for the synthesis of aggregating peptides and proteins is now published in JACS 🥳 Congratulations to first authors Héloïse & Elyse and everyone else involved ✨✨

pubs.acs.org/doi/10.1021/...