AmélieFT@AFTLab

CRCQ : un congrès 2025 plein de vitalité - IRCM

www.ircm.qc.ca/fr/actualite...

Ubiquitin-specific protease 15 interacts directly with the HSV-1 alkaline nuclease and facilitates viral recombination and replication fork stability | Journal of Virology HSV-1 is a ubiquitous pathogen in the global population that causes lifelong latent infection with sporadic reactivation in the host. It has long been appreciated that HSV-1 DNA replication exhibits h...

Very proud to be part of another study from the Mohni lab. journals.asm.org/doi/10.1128/...

Merci Dan 🤗🤗 j’ai du prendre de bons plis à quelque part !!

😆 teamwork!

Merci Mathieu! J'ai la chance d'avoir une équipe de feu!

💚 Merci au CRCQ pour le Prix André-Dupont! Fière de partager nos travaux avec une amie et collègue de toujours @aparentlab.bsky.social ocial, et honorée de retrouver des mentors qui ont façonné mon parcours @ircm.bsky.social 🙌

Merci @aparentlab.bsky.social , l'honneur est pour moi! Quel événement ce sera! Merci au CRCQ 2025 de nous donner une belle occasion de se voir @mathieuferron.bsky.social

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515 Department of Biochemistry, School of Medicine—Basic Sciences

Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...

Thanks a lot Sylvie!

authors.elsevier.com/a/1lbX43vVUP...

💡 Special thanks to @AlexandreMaréchal for inspiring and collaborative discussions on replication stress at every stage of this work!

🙏 Huge thanks to our collaborators: @AlexandreMaréchal, @KyleMMiller, @NitikaTaneja, @JeanYvesMasson, and our institutions @crchuqc @CRC_ULaval @UniversitéLaval @PROTEO.

Mechanistically,
• 53BP1 & RAD18 don’t bind nucleosomes with RNF168-ubiquitinated macroH2A1.2 ;
• macroH2A1.2 blocks their recruitment to certain loci under stress ;
• Disruption of macroH2A1.2 ubiquitination = toxic RAD18 foci ;
• RAD18 buildup at collapsed forks is MUS81 dependent.

This study revealed an unexpected role for histone macroH2A1.2 ubiquitination in preventing replication fork collapse and RAD18-dependent toxicity during prolonged replication stress. When macroH2A1.2 or its ubiquitination is missing, cells become sensitized to specific types of replication stress.

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone mH2A1.2 ubiquitination in p...

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌

www.cell.com/molecular-ce...

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...

Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!

FRADET-TURCOTTE LAB Laboratory of Amélie Fradet-Turcotte. CHU de Québec, Laval University Cancer Research Center, Québec, Canada

Our new Lab website! Come and visit us, and stay tuned for new opportunities!

aftlab.ca

Excited to present Social DNAing tomorrow. I’ll talk about our work led by @szmyd-radoslaw.bsky.social in collaboration with @radoncdocgee.bsky.social.

12 pm Eastern USA

Thanks Shan Zha for the invite.

www.cancer.columbia.edu/research/pro...

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

To my colleagues and friends at NIH, I feel your pain. www.science.org/content/arti...

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...

1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....

Fena Ochs Laboratory

2/2 To learn more about our lab see our homepage: www.ochslab.org
We are an international, multidisciplinary lab focussed on genome stability maintenance & 3D chromatin.
Happy to be contacted with any questions you might have about this job. / Fena

A little boost to finish reports!

The lab Is moving to a new research center, lab members are practicing their wrapping skills!!

😂😂

Back from a great and refreshing 2 days of “science only” in Alberta! First in Edmonton then at the Robson DNA Science Centre 10-Year Anniversary-symposium in Calgary! Thanks Aaron Goodarzi and Pierre Billion for organizing such a great day, it was a blast to see everyone!

Great visit at the Cross Cancer Institute in Edmonton today!! Thanks for inviting me, i really enjoyed my visit!

@marie-anneberube.bsky.social nice picture!!

Hi Tatiana, can you add me to the list?