Alicia

The 1980s ate my bed.
It was the most inexpensive flannel bedding that still counted as flannel. much like the sheets of our childhood.
Nostalgic and warm enough so far.
Also, Skooma.

Skooma's reaction to my rendition of Jolene.
I'll eventually find something she likes.

Summary A team of scientists discovered a hidden antibiotic 100 times stronger than existing drugs against deadly superbugs like MRSA. The molecule had been overlooked for decades in a familiar bacterium. It shows no signs of resistance so far, offering hope in the fight against drug-resistant infections and paving the way for new approaches to antibiotic discovery.

Abstract The methylenomycins are highly functionalized cyclopentanone antibiotics produced by Streptomyces coelicolor A3(2). A biosynthetic pathway to the methylenomycins has been proposed based on sequence analysis of the proteins encoded by the methylenomycin biosynthetic gene cluster and the incorporation of labeled precursors. However, the roles played by putative biosynthetic enzymes remain experimentally uninvestigated. Here, the biosynthetic functions of enzymes encoded by mmyD, mmyO, mmyF, and mmyE were investigated by creating in-frame deletions in each gene and investigating the effect on methylenomycin production. No methylenomycin-related metabolites were produced by the mmyD mutant, consistent with the proposed role of MmyD in an early biosynthetic step. The production of methylenomycin A, but not methylenomycin C, was abolished in the mmyF and mmy mutants, consistent with the corresponding enzymes catalyzing the epoxidation of methylenomycin C, as previously proposed. Expression of mmyF and mmyo in a S. coelicolor M145 derivative engineered to express mmr, which confers methylenomycin resistance, enabled the resulting strain to convert methylenomycin C to methylenomycin A, confirming this hypothesis. A novel metabolite (premethylenomycin C), which readily cyclizes to form the corresponding butanolide (premethylenomycin C lactone), accumulated in the mmyE mutant, indicating the corresponding enzyme is involved in introducing the exomethylene group into methylenomycin C.

Remarkably, both premethylenomycin C and its lactone precursor were one to two orders of magnitude more active against various Gram-positive bacteria, including antibiotic-resistant Staphylococcus aureus and Enterococcus faecium isolates, than methylenomycins A and C, providing a promising starting point for the development of novel antibiotics to combat antimicrobial resistance.

Graphical Abstract

Chemists discovered a powerful hidden antibiotic that’s 100 times stronger than existing ones and effective against deadly superbugs.

The study has been published in the Journal of the American Chemical Society. YES, it is PEER-REVIEWED.
• pubs.acs.org/doi/10.1021/...

🧪🧵⬇️

Stuffed mouse.
vroom vroom

ah, gaming...

I sang Yippie-ki-yay to Skooma 🐈‍⬛️ She looked affronted, ears in airplane form, then stalked out of the room.
No appreciation for kesha.

It's fall enough that I need to bring out my light box.

Piiiimmmeeeeennnnnttooooooo!!!!!!
He broke a glass tumbler. It had coffee in it. A crime both heinous and foul.

#sotd Royal Earth EDP - The Harmonist

Powdery iris. much powder, wow. Earthy/musty wood, like a rotting backyard fence. A little sweet vegetal green in the back peeking in/out. Abuela's iris garden :)
The iris kept ramping up tho. Got a headache on hour 2 :(
I wish it was violet instead of iris.

Trump ordered to fully fund SNAP, Bay Area woman wakes up to full EBT card Lisa Trujillo of Richmond has been checking her EBT card, checking to see how much money she has on it. On Friday morning, she woke up early to a pleasant surprise. Her Electronic Benefit Transfer car...

Links:

www.ktvu.com/news/snap-be...

www.fox6now.com/news/wiscons...

www.easternecho.com/article/2025...

duuuude

What is this "slumber"?

This account smells like:

Cat fur, peppers, an open spreadsheet, chocolate & comfort food, the pages of books & a glass of wine, heavy jasmine on an ocean breeze, sTrEsS, the ink of a freshly written page, vetiver & violets & paints, pure nonsense fueled by a pot of coffee

#perfumesky #scentsky

cute No Touch bebes!

IDK what sins I have committed to end up on Ɛr1Ka Ki.rK's postal mailing list.
But, as penance, i'm gonna donate 1/2 my grocery $ for the month to the @CLU, PBS, pl@nnedpar.ent.h00d, & a local food bank.

Live Results: California 2025 election on Proposition 50 The new map, drawn and passed by the Democratic-controlled state Legislature and pushed by Gov. Gavin Newsom, could help flip five seats from Republican to Democratic in next year’s midterm elections.

www.pbs.org/newshour/pol...

Banana chocolate chip bread pudding

To make them, I used up stale donuts, a brown banana, and chocolate chips that had gotten waxy bloom. Preventing food waste!

I'm going to freeze half of this, so I don't eat it all at once.

vague post: chisme-mas
💜💜💜💜💜

It was so nice. I'm so rarely in truly sapphic spaces, much less with those near my age group. It was like being a kid again. But, being the kid I couldn't be. Because, ya know, c@tholic upbringing.

Post performance tiredness + possible cold kept me from going to an in-person community swap event. :(((

I spent the day online. I had a whirlwind day fueled by coffee, dayquil, and unhinged lesbians. I laughed a lot today, and had laugh induced coughing fits. Definitely worth missing out on swaps.

Has your vote been received?

Find out here.

california.ballottrax.net/voter/

Skooma 🐈‍⬛️ stole a wedge of parmesan cheese and ate part of it. I discovered this too late. She is running around the house, uncatchably fast, barfing. She's doing a fair imitation of a fire hose, but with vomit
#catowner

#sotd Lemon Creme by Ganache Parfums, layered w/Milk by Commodity
Normally lemon creme is a lemon bar & Milk is a woody marshmallow. The lemon & woods gets aggressively furniture-polishy on me. The marshmallow seems sharp. Any nuance each had eaten by the other. No biscuit or cream note. Sweet tho.

Each cat has a different sounding bell on their collar. so that way, I know which little m9therf*ck3r just attacked me in the middle of the night.
It was Pimento.

I've never been so happy to have a t0xic mess walk back into my life.
May the show be grand. May only willing participants be bruised. May I remain, always, in the audience.
*knocks wood*
*spins around 3x clockwise*

DOJ prepares to send election monitors to California, New Jersey following requests from state GOPs The Department of Justice is preparing to send federal election observers to California and New Jersey next month, targeting two Democratic states holding off-year elections following requests from th...

Federal election monitors are coming to California after MAGA Republicans demanded “oversight.” Make NO mistake, our elections are safe and secure. What they fear isn’t fraud – it’s working people voting. #YesOnProp50

apnews.com/article/doj-...

oh gawds, how can Skooma smell so bad? 🤢

The cats have discovered cabinets. I need to baby proof the doors now.
I think the magnetic locks have proven to be the most disability friendly for me in the past. But, if anybody has better suggestions, I'm all ears.

yup.