Pavithra Viswanath

Now we’re finally talking!

www.politico.com/news/2025/03...

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment - Nature Reviews Cancer In this Review, Polak, Zhang and Kuo discuss the currently available and rapidly evolving 3D tumour organoid models that capture the tumour immune microenvironment. They highlight opportunities for organoid-based investigations of tumour immunity, drug development and precision medicine.

🥳 Our 5th most downloaded article in 2024:

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment by Calvin Kuo, Polk & Elisa Zhang

https://bit.ly/4jAOu...

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Join us on March 13-14, 2025, for a special in-person postdoctoral recruitment event @winshipatemory.bsky.social. Network with mentors and postdocs in our Cancer Research programs, and explore our community and career resources. Apply by January 31, 2025. Details & Application: brnw.ch/21wPrWk

So important to mention this when talking to politicians or the public: $2.64 of economic activity for every $1 of NIH research funding!

Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomas https://www.biorxiv.org/content/10.1101/2025.01.02.631150v1

Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomas Oncogenes hyperactive lactate production, but the mechanisms by which lactate facilitates tumor growth are unclear. Here, we demonstrate that lactate is essential for nucleotide biosynthesis in pediat...

First post on Bluesky- new preprint! We show that lactate drives NTP synthesis via lactylation of the nucleoside diphosphate kinase NME1 in pediatric gliomas. Deuterium metabolic imaging of lactate production interrogates tumor growth and therapy response in vivo. www.biorxiv.org/content/10.1...