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Alex Prados

@aprados.bsky.social

Postdoc at IRB Barcelona in the Battle Lab. Previously, I explored lymphoid organ functions and inflammatory bowel disease in George Kollias' Lab. Excited to launch my independent research as a "Ramon y Cajal" Researcher at UGR in Sept 2025!

746 Followers  |  1,027 Following  |  3 Posts  |  Joined: 13.11.2024  |  1.8674

Latest posts by aprados.bsky.social on Bluesky

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Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signalling in murine ileitis - Nature Communications The TnfΔΑRE mice overexpress TNF, resulting in ileitis, showing strong similarity to Crohn’s disease in human patients. Here authors describe the immune pathology of the murine disease model by single...

🚨Excited to share our latest study!🚨

Using TnfΔARE mice & scRNA-seq, we reveal how villus-associated fibroblasts 🔥 ignite inflammation & TLO formation, while trophocytes 🏗️ drive granuloma buildup—shedding new light on fibroblasts' key role in Crohn’s-like ileitis.

#Inflammation #Fibroblasts

29.03.2025 10:41 — 👍 2    🔁 0    💬 0    📌 0
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Como ella, muchos estaríamos criando malvas si no existiera la sanidad pública.
Por eso hay que luchar por ella, con uñas y dientes, nos va la vida.

14.01.2025 18:38 — 👍 1437    🔁 550    💬 29    📌 12

Can I get a piece of this pie? 🙋🏻

17.11.2024 18:36 — 👍 1    🔁 0    💬 0    📌 0

Another TME researcher.🙋 Can I enroll?

17.11.2024 18:33 — 👍 1    🔁 0    💬 1    📌 0
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Targeting immune–fibroblast cell communication in heart failure Nature - A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling...

More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case)
#ImmunoSky

www.nature.com/artic...

15.11.2024 15:02 — 👍 21    🔁 8    💬 0    📌 0
Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures Background Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of malignant cells led to major advances in the understanding of cancer treatments. Yet, a major limitation is the...

Check out our new paper: a milestone in the establishment of a line-up of in vitro models for #precisionmedicine was reached. In a joint effort with the team of M. Bergmann #MedUni_Wien, we published the first out of several papers in #jitcancer: bit.ly/3YRbsTh 1/n
#Immunology #Immunosky #cancersky

15.11.2024 10:48 — 👍 46    🔁 5    💬 1    📌 0
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single-cell computational methods Join the conversation

in case this is useful to someone in this massive platform migration: a starting pack for single-cell omics computational methods
go.bsky.app/GmS1cH

15.11.2024 11:11 — 👍 99    🔁 47    💬 15    📌 2

I’m thrilled to share the Pancreatic Cancer Starter Pack! If you want to join DM go.bsky.app/2FHVVL6

15.11.2024 12:15 — 👍 5    🔁 7    💬 4    📌 1

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