Chris Kotanidis

How Win Ratios Work This Stats, STAT! animated video explores the use of win ratios in clinical trials — a method that allows investigators to analyze a composite hierarchy of outcomes.

evidence.nejm.org/doi/full/10....

YouTube video by NEJM Group How Win Ratios Work | NEJM Evidence

The win ratio method is gaining traction in #RCTs. Is it just a trend or a smarter way to look at composite hierarchical outcomes? We break it down in our latest Stats, STAT!📊 in NEJM Evidence. youtube.com/watch?v=jKtF... #stats @nejm.org @sarahgorey.bsky.social @chardin.bsky.social @ai.nejm.org

1/ 🚨 NEW #BeyondJournalClub w/ @nejm.org: REDUCE-AMI

What is the long term benefit of beta blockers in patients with preserved EF following an MI?

🖥️: www.coreimpodcast.com/2025/06/25/b...

Early Invasive or Conservative Strategies for Older Patients With Acute Coronary Syndromes

In older patients with acute coronary syndrome, an early invasive strategy did not reduce all-cause mortality but decreased recurrent myocardial infarction and repeated revascularization. https://ja.ma/40hDK9G

What is it like to be an NEJM editorial fellow for a year? This year’s fellows discuss what they have learned, how their experience will help their career, and what surprised them. Apply for the 2026–27 NEJM editorial fellowship by August 1. Learn more: nej.md/3cCQajB

#MedSky #MedEd

60-Second Journal Club: The SUMMIT trial examined cardiovascular outcomes of treatment with tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Read the full trial results: nej.md/4hRGaTY

#MedSky #CardioSky @cpkotanidis.bsky.social‬

Aspiration Thrombectomy for Coronary Stent Thrombosis Panel A: Coronary angiography revealing a large thrombus in the LAD artery stent. Panel B: The thrombus that was removed with the use of an aspiration catheter. Panel C: The stent that was dilated with a balloon at high pressure, which resulted in improved flow.

A 73-year-old woman presented with severe chest pain. She had undergone multivessel percutaneous coronary intervention 2.5 years earlier. Angiography revealed a large thrombus in an LAD artery stent (shown in videos). Read the full case details: nej.md/4jC2aSa

#MedSky #CardioSky

Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏

Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy Radiotherapy (RT) is known to reduce the rate of disease recurrence following breast-conserving surgery in patients with breast cancer, but also entails ir

New research alert: Our latest report highlights a significant reduction in coronary #inflammation and residual inflammatory risk as captured by #CCTA imaging using CaRi-Heart AI in women with #BreastCancer 2 years post-RT
#AI #CardioOncology #CardioEd #EHJ
@escardio.bsky.social

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation | NEJM Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence t...

Presented at #ACC25:

In the PROTECT-TAVI trial, the routine use of cerebral embolic protection during TAVI did not reduce the incidence of stroke within 72 hours or before discharge from the hospital (if discharge occurred sooner). Full trial results: nej.md/41RONXi

@accintouch.bsky.social

YouTube video by NEJM Group How Interim Analyses Work | NEJM Evidence

YT link: www.youtube.com/watch?v=to81...

How Interim Analyses Work This Stats, STAT! animated video explores interim analyses in clinical trials. During these evaluations of the data, researchers may assess safety, efficacy, and verify sample size assumptions, but...

Ever wondered how interim analyses work in #RCTs? 📊 Check out our Stats, STAT! video at NEJM Evidence: @nejm.org @ai.nejm.org @sarahgorey.bsky.social evidence.nejm.org/doi/full/10.... #MedStats #ClinicalTrials

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Tirzepatide was previously shown to provide sustained weight reductions in adults with #obesity. Longer-term findings in adults with both obesity and prediabetes are summarized in a new Quick Take video. youtu.be/c9uazgSdDJc

#MedSky #EndoSky

Early Versus Delayed Invasive Management of Female Patients With Non–ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis | Circulation: Cardiovascular Interventions BACKGROUND: Female patients are at greater risk of adverse events following non–ST-elevation acute coronary syndrome but less frequently receive guideline-recommended coronary angiography and revascul...

🫀New research🫀 Across 6 #RCTs (n=2,257) early invasive management in #female patients with #NSTEACS did not reduce all-cause mortality or MI risk at 6 months vs. delayed management. #AHAJournals @drroxmehran.bsky.social @vijaykunadian.bsky.social
www.ahajournals.org/doi/10.1161/...

In the HELIOS-B trial, researchers assessed the efficacy and safety of vutrisiran in patients with transthyretin amyloidosis with cardiomyopathy. NEJM Editorial Fellow Christos Kotanidis, MD, DPhil, summarizes the results. Full trial: nej.md/3X5nl5Q

#MedSky #CardioSky @cpkotanidis.bsky.social

EDITORIAL “What can we do to counter the current chaos? At the least, we can try to maintain order. In our roles as editors, this means continuing to do what we think makes a difference: publishing the highest-quality research, analysis, opinion, and educational content that can improve patient health.” “Order out of Chaos” by NEJM Editor-in-Chief Eric J. Rubin, M.D., Ph.D.

In a new editorial, NEJM Editor-in-Chief Eric J. Rubin, MD, PhD, comments on the effects of the raft of executive orders from the current administration on scientific research and public health. Read the full editorial: nej.md/4gXeRFW

#MedSky

A Swell Diagnosis | NEJM This Double Take video explores the differential diagnosis for a man with recurrent severe diffuse abdominal pain without obvious associated symptoms and reviews how the diagnosis evolves with new ...

🤔Recurrent severe abdominal pain with no clear cause? In the latest #NEJMDoubleTake we unpack a perplexing case with a broad differential, key clinical clues, and a surprising diagnosis. 🎥🩺 🏥🔬 nejm.org/doi/full/10.... @nejm.org