Congratulations Dr. Manel! 🎈

Programme of the upcoming TriRhena Gene Regulation Club in Basel on November 5, 2025 https://www.ie-freiburg.mpg.de/gene-regulation-club

Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45).

Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI).

www.ie-freiburg.mpg.de/grc

Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....

Our paper is now out in Molecular Cell!

Check the thread in this former post:

www.cell.com/molecular-ce...

I am grateful for the encouraging feedback I received from the scientific community and for the opportunity to learn from many insightful talks and engage in meaningful discussions with inspiring scientists and colleagues!

The meeting was chaired and organised by Dr. Ana Pombo and Dr. Wei Xie, and it was a truly outstanding event that fostered networking among senior scientists, early-career researchers, and trainees like myself.

Last week, I had the opportunity to attend this inspiring conference, held in the beautiful city of Ventura, California.

I am excited and honoured to share that I was selected as a recipient of the 𝐁𝐞𝐬𝐭 𝐏𝐨𝐬𝐭𝐞𝐫 𝐀𝐰𝐚𝐫𝐝 at the 𝟐𝟎𝟐𝟓 𝐆𝐨𝐫𝐝𝐨𝐧 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐨𝐧 𝐆𝐞𝐧𝐨𝐦𝐞 𝐀𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐞 𝐢𝐧 𝐂𝐞𝐥𝐥 𝐅𝐚𝐭𝐞 𝐚𝐧𝐝 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 🎉.
(see 🧵 below)

Chip (Ldb1) is a putative cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation Chip/Ldb1 is a crucial cofactor regulating enhancer function and chromatin interactions. Using optogenetics, Galouzis, Kherdjemil et al. show that Chip is only essential during zygotic genome activati...

Check our latest with Yacine Kherdjemil and @eileen-furlong.bsky.social and our colleagues, where we show Chip (Ldb1) is essential only at a narrow window of embryogenesis overlapping ZGA. It functionally and physically bridges CBP to Zelda to regulate gene expression. www.cell.com/molecular-ce...

Congratulations to everyone ! 🥳 Thank you so much Dr. Manel for your supervision during my master thesis! I am so happy to be part of this collaborative effort!

Decoupling chromatin hubs from gene control - Nature Structural & Molecular Biology Chromatin hubs, which are formed during cell differentiation, are characterized by simultaneous interactions between multiple regulatory elements and gene promoters. Research now shows that the disrup...

Congratulations to first authors Magdalena Karpinska and Yi Zhu and many thanks to all co-authors and the very helpful editors and reviewers! Special thanks to @dariloops.bsky.social for a great summary: www.nature.com/articles/s41...

Congratulations to all! Thank you so much for including me in this work!

Many congratulations to *Dr.* Shyam Ramasamy for a fantastic PhD thesis & defence! A very well deserved summa cum laude 🥳

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
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