Iβll be there and would be enthusiastic to chat Bindcraft, crystals, etc.
28.06.2025 03:16 β π 1 π 0 π¬ 1 π 0@cdsnow.bsky.social
Professor at Colorado State University. Previously MIT Chemistry (Tidor), Stanford Biophysics (Pande), Caltech Chemistry and Chemical Engineering (Arnold). Interests: Protein Engineering, Computational Protein Design, ML, Biomolecular Crystals
Iβll be there and would be enthusiastic to chat Bindcraft, crystals, etc.
28.06.2025 03:16 β π 1 π 0 π¬ 1 π 0Making intrabodies from antibodies just got easier! Learn how we made ππ΅ intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
Very pleased with this ProteinMPNN-based collaboration that ballooned to encompass an impressive number of redesigned proteins for intracellular biomolecular recognition! www.biorxiv.org/content/10.1...
11.02.2025 23:18 β π 5 π 2 π¬ 0 π 0Protein cartoon, mostly depicted in blue for very high confidence (pLDDT) despite extended N-terminus as it exists in a domain swap...
AlphaFold3 Cautionary Tale: We deposited multiple PDB entries for βCJ,β a binding protein that domain swaps when crystallizing. Local AF3 in the presence of decane gives the domain swapped form with high confidence extended N-terminus (4/5 models). Yikes! Perhaps template-driven false confidence...
25.11.2024 20:01 β π 4 π 0 π¬ 0 π 0The W Scott College of Engineering has announced a cluster of 10 new openings for tenure track professors in Engineering with Artificial Intelligence. We'd love for you to join our beautiful and supportive community! Please repost.
jobs.colostate.edu/postings/152...
Wouldn't mind being in Pack 2 or a future one -- we're doing a variety of ML-enabled protein engineering projects from intracellular binding proteins to biomolecular crystal engineering.
20.11.2024 18:54 β π 1 π 0 π¬ 0 π 0Hi folks, to those teaching courses where it is useful to know the one letter amino acid code, I used Suno to make a mnemonic song (Bossa nova style...)
suno.com/song/8ce2f2e...