Nunzio Morabito

High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing - Nature Neuroscience Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.

www.nature.com/articles/s41...

20.09.2025 10:53 — 👍 0    🔁 0    💬 0    📌 0

CRISPR activation for SCN2A-related neurodevelopmental disorders Nature - Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in...

SCN2A loss is strongly linked to neurodevelopmental delays and, at times, seizure. In an amazing collaboration with @nadavahituv.bsky.social, led by Serena Tamura, Andrew Nelson, and Perry Spratt, we leveraged CRISPR activator approaches to rescue this loss.

rdcu.be/eGU0W

17.09.2025 18:27 — 👍 73    🔁 21    💬 9    📌 4

thanks 🙂

30.06.2025 16:53 — 👍 0    🔁 0    💬 0    📌 0

Distinct dendritic integration strategies control dynamics of inhibition in the neocortex Morabito et al. observed that different neocortical interneuron (IN) populations display distinct dendritic properties by varying synaptic receptor composition and input location. These IN-specific de...

Happy to share that our work is out in Neuron today! We found that of PV and SST interneurons present distinct dendritic strategies, key to maximize synaptic efficacy and shape firing dynamics of these cells.
www.cell.com/neuron/fullt...

30.06.2025 15:50 — 👍 3    🔁 0    💬 1    📌 0

I am so excited about this combined analysis of the selective CRHR2 population within the lateral septum and how they control defensive behavior. Dionnet was truly a gifted graduate student. Keep your eyes on this one!

16.06.2025 13:20 — 👍 10    🔁 1    💬 0    📌 0

Viva l'Italia liberata 🇮🇹

25.04.2025 12:11 — 👍 1    🔁 0    💬 0    📌 0

In Rome today 50k people at the demonstration pro-Europe.

15.03.2025 20:08 — 👍 458    🔁 119    💬 5    📌 10

A Neuropixels Opto probe with 3 blue emitters and 3 red emitters lighting up in succession, with corresponding neural activity in different layers of the cortex.

Neuropixels and Optogenetics are delighted to announce the birth of

Neuropixels Opto

Combining high-resolution electrophysiology and optogenetics

Today in bioRxiv

960 sites, 28 emitters, 2 colors

By Lakunina, @karolinazsocha.bsky.social, Ladd, et al

www.biorxiv.org/content/10.1...

(1/2)

07.02.2025 09:18 — 👍 325    🔁 115    💬 7    📌 12

Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the human hippocampus is distinct from both rodent counterparts and human neocortical circuits.

www.cell.com/cell/fulltex...

12.12.2024 23:49 — 👍 2    🔁 0    💬 0    📌 0

www.biorxiv.org/content/10.1...

28.11.2024 01:52 — 👍 2    🔁 0    💬 0    📌 0

Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors GPCR-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. While experiments in transfected cells often reveal selectivity for individual neurotransmitt...

www.biorxiv.org/content/10.1...

A must-read from the Kaeser lab

23.11.2024 21:28 — 👍 4    🔁 2    💬 0    📌 0

Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons Information storage in neuronal circuits is hypothesized to involve nanoscopic structural changes at synapses, but direct evidence for this is lacking. This study uses nanophysiology and functional el...

journals.plos.org/plosbiology/...

19.11.2024 21:44 — 👍 2    🔁 0    💬 0    📌 0