fighumphlab

big congrats Vijay and team !

Interferons in human inborn errors of disease | mBio Interferons (IFNs) are a family of pleiotropic cytokines traditionally associated with anti-viral and anti-tumor immunities (1). IFNs are ubiquitously produced in response to infection, damage, or cel...

thanks to @mbio.bsky.social for the invitation to write this review on Interferons in human monogenic diseases. Written with two superstar @umassgrad.bsky.social students Laurel Stine and Sara Cahill. @umasschan.bsky.social @umassmedicine.bsky.social

journals.asm.org/doi/10.1128/...

Patterns of pathogenesis in innate immunity: insights from C. elegans - Nature Reviews Immunology In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...

In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...

Inflammasomopathies: mechanisms and disease signatures Inflammasomes form in response to infection, cellular stress, or damage. Gain-of-function (GOF) mutations in inflammasome receptors have been identified as the underlying cause of severe inflammatory ...

New review from my lab out today in @cp-trendsimmuno.bsky.social we discuss in born errors in human inflammasomes and disease signatures beyond IL-1. @umasschan.bsky.social @umassmedicine.bsky.social

www.cell.com/trends/immun...

Review @cp-trendsimmuno.bsky.social
Inflammasomopathies: mechanisms and disease signatures
www.cell.com/trends/immun...

MARCO is an IFN-restricted immunometabolic decoy LPS receptor
doi.org/10.1101/2025...

MARCO is an IFN-restricted immunometabolic decoy LPS receptor Intracellular sensing of lipopolysaccharide is an essential component of pathogen detection that governs the innate immune response. However, how this process is controlled to maintain homeostasis and...

Sharing my labs first pre-print ! We discovered a remarkable innate checkpoint in macrophages ! Congrats to tall the authors @umassmedicine.bsky.social @umasschan.bsky.social

www.biorxiv.org/content/10.1...