Xiaojun Tian

Using nature’s playbook to keep engineered cells on script | ASU News When it comes to organization, even cells have their own preferred system.While genetic engineers can design and assemble sophisticated gene circuits to program cells with new functions, as these cell...

Check out the ASU News story highlighting our Cell paper， Using nature’s playbook to keep engineered cells on script news.asu.edu/20251110-sci...

Free access link: authors.elsevier.com/a/1m3mVL7PXu...

Phase separation to buffer growth-mediated dilution in synthetic circuits Phase separation stabilizes synthetic gene circuits and boosts production under dynamic growth conditions. By locally concentrating transcription factors at promoters, it protects gene expression from...

Excited to share our new Cell paper!
Liquid–liquid phase separation (LLPS) provides a powerful way to stabilize synthetic gene circuits by buffering growth-mediated dilution—adding a spatial layer of control beyond network design.
Grateful to all collaborators! www.cell.com/cell/fulltex...

We’re Hiring Professor (all ranks) in Synthetic Biology and AI-Enabled Biodesign at the School of Biological and Health Systems Engineering, Arizona State University.📍 Tempe, Arizona

Apply here: apply.interfolio.com/175856

Integrating recombinase-based feedback and feedforward control for optimal resource decoupling Abstract. Resource competition disrupts circuit modularity by introducing unintended coupling between otherwise independent gene modules, thereby compromis

Our new NAR paper is out! We turned a recombinase-based negative feedback circuit into a combined feedback+feedforward controller with one promoter flip—tunable resource decoupling achieved. Congrats to our 3rd-year PhD student 🎉 academic.oup.com/nar/article/...
academic.oup.com/nar/article/...

CRISPRi-Linked Multimodule Negative Feedback Loops to Address Winner-Take-All Resource Competition Cellular resource limitations create unintended interactions among synthetic gene circuit modules, compromising circuit modularity. This challenge is particularly pronounced in circuits with positive ...

Now this is out at @ACS Synthetic Biology pubs.acs.org/doi/full/10....

CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition Cellular resource limitations create unintended interactions among synthetic gene circuit modules, compromising circuit modularity. This challenge is particularly pronounced in circuits with positive ...

🆕 Another preprint!
CRISPRi-linked multi-module negative feedback loops to combat winner-take-all dynamics from resource competition in gene circuits.
📄 www.biorxiv.org/content/10.1...
#SynBio #CRISPRi #GeneCircuits #ResourceCompetition

Integrating Recombinase-Based Feedback and Feedforward Control for Optimal Resource Decoupling Resource competition disrupts circuit modularity by introducing unintended coupling between otherwise independent gene modules, thereby compromising genetic circuit function. While various control str...

🚨 New preprint!
We present Re-NF-FF-Controller—a compact strategy that integrates negative feedback and feedforward control via a single promoter flip to optimally decouple resource competition.
📄 www.biorxiv.org/content/10.1...
#SynBio #GeneCircuits #ResourceCompetition

Latest report from a highly credible source. An SRO issuing study section guidance to not address the Diversity Plan or include it in the impact score for a mechanism that required the plan to be included.

If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you

Director, Institute for Quantitative and Computational Biosciences University of California, Los Angeles is hiring. Apply now!

#UCLA QCbio qcb.ucla.edu is looking for a new director! recruit.apo.ucla.edu/JPF10007 Please share

Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg.
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...

Our new work demonstrated the idea of using a supplementary repressive link to enhance the synthetic gene circuit stability under growth feedback.

academic.oup.com/nar/advance-...

Research Associate/ Senior Research Associate - Sequencing - Achilles Therapeutics Achilles is a fast paced, trail blazing company focused on the development of the next generation of personalised T cell therapies to treat cancer. We are breaking new ground with our science - there...

Open position for a molecular biologist in a brand new sequencing lab at Achilles Therapeutics, a London-based biotech SME working on cancer immune therapies. If interested please get in touch! 👇

apply.workable.com/achilles-the...

Light-driven synchronization of optogenetic clocks https://www.biorxiv.org/content/10.1101/2023.10.24.563722v1 Synthetic genetic oscillators can serve as internal clocks within engineered cells to program period

Light-driven synchronization of optogenetic clocks https://www.biorxiv.org/content/10.1101/2023.10.24.563722v1

Our Holobiont Research centre has 2 bioengineering postdoc places on offer, inc. a synthetic biology one in my group. Interested in engineering microbes to live within native communities and sense and record inputs? Then this job could be for you👇

www.jobs.ac.uk/job/DDO637/r...

A three-node Turing gene circuit forms periodic spatial patterns in bacteria https://www.biorxiv.org/content/10.1101/2023.10.19.563112v1 Turing patterns1 are well-known self-organising systems that can form spots, stripes, or labyrinths.

A three-node Turing gene circuit forms periodic spatial patterns in bacteria https://www.biorxiv.org/content/10.1101/2023.10.19.563112v1