@JohnGrossSF

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

Word. Show PAE plot and considering using ChimeraX nice tool for mapping PAE data onto the predicted complex. I also think iPTM is a good metric for evaluating complexes. pax,

Structures and functions of low-complexity domains - Lasker Foundation For their discovery of the two distinct classes of lymphocytes, B and T cells – a monumental achievement that provided the organizing principle of the adaptive immune system and launched the course of...

Order from Chaos in protein LCDs acknowledged by the Lasker Foundation, laskerfoundation.org/winners/stru...

Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18

Texas researcher faces deportation after being held for week at San Francisco airport A legal permanent resident with a green card who flew back to the U.S. after visiting family in South Korea was detained by immigration authorities and held for more than a week at the San Francisco I...

apnews.com/article/texa... researcher faces deportation after being held for week at San Francisco airport

Another email to Bhattacharya about his interview and his continued statements that NIH's gain of function research caused the COVID pandemic and killed millions of people.

1/8

Picture of a smiling person holding up a copy of a book.

First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.

This book is the guide I wish I’d had then, with the goal of helping others now.
 
jenheemstra.com/book

Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showe...

Proud to share our work where we resolved a longstanding question regarding the existence of a human telomerase dimer and provided insights into its function. Led by 3 amazing lab members in collaboration with @yiliangding.bsky.social and @rdaslab.bsky.social.
www.science.org/doi/10.1126/...

The Surprising Scientists Hit by Trump’s D.E.I. Cuts

Powerful story from Kate Zernike from the NYT

Covers the diversity of young scientists targeted by the anti-DEI BS. Definitely worth a read and a share.

[Gift link]
www.nytimes.com/2025/07/10/u...

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

Yes, back in the day (meaning in the 1990s) we would mix down from 400 MHz direct signal to audio frequency using a doubly balanced mixer (analog) and then run the signal through an ADC --the NMR spectrum is just the FFT of this signal . Your setup is all digital, right?

Us cancer survival statistics

A reminder. The budget that just passed the House slashes US scientific research by half. Please call or email your senators and tell them you do not want the NIH and NSF cut. You can find your senators contact info here: www.senate.gov/senators/sen...

Cool Wallace, we do something like this in NMR--mixing down from 600-800 MHz to audio frequency to get at the useful information.

(Longish thread. Apologies)

I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/

Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2 - Nature Structural & Molecular Biology Guided by a structure of VGLUT2 with substrate, Li et al. identify the mechanisms for selective substrate recognition, a role for lipid modification in limiting axonal dispersion and for the cytoplasm...

Congratulations to Fei Li, Bob Stroud , Rob Edwards and coworkers for VGLUT2 structure , substrate recognition and allosteric regulation.
www.nature.com/articles/s41...

Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.

This looks very cool Jeff, congratulations to you and your team!

💥Latest preprint from our lab is now live! We propose a crazy(!?) new mechanism for how the radical SAM enzyme Elp3 (a subunit of the Elongator complex) modifies tRNA! #RNAsky #enzymes 🧵...

DARTH VADER: I just want to say to all of the alderaanians.. I see you. I hear you

A kinetic ruler controls mRNA poly(A) tail length Poly(A) tails of newly synthesized mRNAs have uniform lengths, arising through cooperation between the cleavage and polyadenylation complex (CPAC) and poly(A) binding proteins (PABPs). In the budding ...

New work from Matti Turtola showing that mRNA poly(A) tail length is controlled by a kinetic ruler. A real pleasure to work with him!
www.biorxiv.org/content/10.1...

Deciphering disordered regions controlling mRNA decay in high-throughput - Nature Using high-throughput functional profiling, how disordered regions control mRNA stability and translation is explored.

The unstructured biology of mRNA decay in budding yeast revealed by motif discovery engine developed by Joe Lobel and @nickingolia.bsky.social . Kudos!
www.nature.com/articles/s41...

Our work on HIV-1 matrix, led by James Stacey and @dhrebik.bsky.social, is in this week's @nature.com. Extended explanatory video from @margotriggi.bsky.social.

www.nature.com/articles/s41...

Congratulations!

Non-canonical acylation of lysine residues catalyzed by HDACs! Congratulations to @dremilygoldberg.bsky.social for such beautiful work and thanks for bringing us along for the ride!

I'll add you to my anger management support group.

Trim Away and variations of that approach are very exciting; congratulations and good luck!

Sign the Petition Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

5 Calls Spend 5 minutes. Make 5 calls. Make your voice heard.

Ok scientists & those who love science 🧪: here is another exhortation. Call Congress TODAY about the freeze on NIH Council Meetings and Study Sections. Emphasize that this means NO new grants are being funded & labs will soon start to shut down and fire employees. Phone numbers are at:
5calls.org

Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response Open Reading Frame 9b (Orf9b), an accessory protein of SARS-CoV and -2, is involved in innate immune suppression through its binding to the mitochondrial receptor Translocase of Outer Membrane 70 (Tom...

🚨 New preprint alert! 🚨 How does SARS-CoV-2 use as much of its genome as possible to evade our immune response? Our latest study dissects how Orf9b, which is encoded in an alternate reading frame from the N(ucleocapsid) protein, can regulate interferon signaling.
www.biorxiv.org/content/10.1...
🧵👇

Trump maintains funding freeze at NIH, defying court order The Trump administration is still prohibiting National Institutes of Health (NIH) staff from issuing virtually all grant funding, an NIH official tells Popular Information.

Finally read popular.info/p/trump-main...

"Between February 3, 2024, and February 10, 2024, the NIH issued 513 grant awards totaling $218,273,053. Between February 3 and February 10 this year, the NIH issued just 11 grant awards totaling $4,981,089."

No wonder I didn't many responses about NoAs...