Yosef (Yossi) Buganim

Congrats Yaniv and team

Thank you Yaniv!

@stemcells.bsky.social

(4/n) Huge kudos to the amazing members of the Buganim and Soufi labs for their incredible efforts! 🙌 I truly believe this work redefines our understanding of how cell type-specific gene expression is orchestrated and how cell fate determination is established. 🌟

(3/n) Our study reveals that transcription factor combinations use distinct strategies to locate enhancers:
• OSKM factors leverage motif orientation within chromatin loops to target pluripotent enhancers.
• GETM factors use looping junctions to locate trophectoderm enhancers.

(2/n) We identified a previously uncharacterized DNA element adjacent to enhancers, which we’ve termed the "signpost." This element facilitates transcription factor binding near enhancers, enabling precise targeting and activation.

Nucleosome fibre topology guides transcription factor binding to enhancers - Nature Motif grammar on nucleosome fibres acts as signpost elements, directing TF combinatorial binding to enhancers.

www.nature.com/articles/s41...

(1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀 Check out our latest collaborative work with the Soufi lab, now published in @Nature

(2/n) We identified a previously uncharacterized DNA element adjacent to enhancers, which we’ve termed the "signpost." This element facilitates transcription factor binding near enhancers, enabling precise targeting and activation.

www.pnas.org/doi/10.1073/...

Happy to share our recent collaborative study with the Cedar and Stanger labs, identifying the barrier responsible for incomplete epigenetic reprogramming in both in vitro and in vivo transdifferentiation models.

Ananda Labs: Slowing down the aging process Ananda Labs is developing novel solutions for aging-related conditions from wrinkles, to scars to a more youthful immune system through epigenetic editing.

Ananda Labs, founded by @HebrewU
's Prof. Yossi Buganim, was featured in @ISRAEL21c
for its groundbreaking research on reversing aging. Their epigenetic reprogramming tech targets age-related diseases, rejuvenates skin, and boosts immune health.

www.israel21c.org/the-company-...