Michael Bogdos

Nature Catalysis, my favourite physical chemistry journal

We have two open PhD positions to start our new group at University of Geneva!
If you are interested in organometallic chemistry, heterometallic complexes and mechanistic investigations, please contact me. Check more details here:
jobs.unige.ch/www/wd_porta...

Thanks for the suggested reading

Could you please walk me through how this works? I've been trying to understand this argument for ages and cannot find sources with hard numbers. It implies that, excluding marketing costs (which are huge), companies are selling at a loss in all other places which I simply cannot find evidence for.

Blunt letter to the editor on ACS: "If ACS won’t stand up now, it should stand down." cen.acs.org/business/Rea... #chemsky 🧪⚗️

100 %.

Very frustrating that EU institutions increase funding when they eye US researchers, but don't care about scientists in Europe who leave science for other careers in droves. Why endorse American exceptionalism?

That is to say nothing of the intra EU inequality, a whole other can of worms.

Pharma CEOS Speaking Up, Damn It

Re-upping this post this morning: Big Pharma CEOs are finally starting to speak out about the Trump administration.

Unfortunately, they’re smiling and clapping.

Stand Up And Be Counted

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.

Silence gives consent. And no one should consent to this.

When the federal government abandons important areas of funding and leaves a gaping hole in the advancement of science, any prudent funder would fill the hole, not follow suit. I don’t know the rationale here but seriously WTF?

Disclosure: HHMI paid my way through graduate school.

Hey American PIs. If you have undergrad students who, for whatever personal reasons might find it...appropriate to not do grad school in the good ol' US of A for the next 4+ years, I (and my colleagues at UWindsor Chem) are open to applicants. They pay Canadian domestic rates at UWindsor.

And you WON'T BELIEVE the incentives the Canadian Government will give you to just do R&D in Canada. It's literally insane. Anyways, happy to talk and connect people if anyone is interested. Things might get rocky for a bit, and staff might be happier living somewhere that thinks they are humans.

How does one include all sources of error for a quantity of interest obtained by fitting a model e.g. rate constants from kinetics?

Simulations give the answer:

atigdnc.netlify.app/post/error_handling/

tldr; fit each dataset, propagate and combine errors (or random effects model). #chemsky

Wrapping up 2024 - quite the year! I defended my PhD, after more than 4 years at ETH.

Here's hoping 2025 has something just as exciting in store!

Experimental results here:

foundry.adaptyvbio.com/competition

Along similar lines, the results of the second protein binder design competition were announced and de novo design didn't do so well:

www.adaptyvbio.com/blog/po103

I think that just like with protein prediction, the community should now only look at the results of competitions (à la CASP).

The docking equivalent is:

cache-challenge.org

www.nature.com/articles/s41...

Coupling of unactivated alkyl electrophiles using frustrated ion pairs - Nature A transition-metal-free platform enables the formation of challenging C(sp3)–C(sp3) bonds in organic compounds via single-electron transfer, facilitating the coupling of functionalized fragments and e...

New radical cross-coupling using phosphonium salts and HMDS anion as the electron donor:

www.nature.com/articles/s41...

I watched Sven lead this work experimentally and computationally and was very impressed - very rare for someone to be so adept at both. Great to see his hard work pay off.

For trans day of remembrance, this is Ben Barres.
Ben was a remarkable biologist who transformed our understanding of brain function. Born in 1954, he transitioned from female to male in the late 1990s.

My first FA of my PhD investigated the factors controlling the β-Η/β-Χ competition in Pd(II) alkyls:

rdcu.be/cVqUz

The eagle-eyed will notice that we did not address the relative metal electronics at T-shaped vs. square-planar Pd(II) (minor spoilers for upcoming research).

#chemsky

An amazing thing to say. Whoever it was has a greatly inflated idea of what the Big Labs are able to think of and to cover.

Restoring protein glycosylation with GlycoShape - Nature Methods GlycoShape is an open-access web-based platform designed to supplement three-dimensional glycoprotein structures with missing structural information on glycans. To link them, the Re-Glyco algorithm ev...

A tool for predicting glycosylation based on structure:

www.nature.com/articles/s41...

Hopefully this is broadly generalizable, it would be invaluable.

Has anyone ever collected solution state NMR spectra on a protein immobilized on beads? #NMRchat

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#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

Joining #chemsky, I'll revisit some previous research, while I wait for review on the latest.

In 2023, we reported scXRD of N-O OA of Ni(0) to isoxazoles (acs.organomet.2c00533), illustrating a long-proposed mode of catalyst poisoning. Contrary to the literature, we did not observe this for Pd(0).

An Air-Stable, Single-Component Iridium Precatalyst for the Borylation of C–H Bonds on Large to Miniaturized Scales The functionalization of C–H bonds enables the modification of complex molecules, often with the intention of forming compound libraries. The borylation of aryl C–H bonds is a widely used class of C–H...

Definitely a must read Amazing work from the @HartwigGroup out in @J_A_C_S
Air stable Ir precat for C-H borylation with large scope and 1-pot Borylation-Suzuki, bromination or Chan-Lam
Super paper and will be of high use in med chem #ChemSky