Feedback between F-actin organization and active stress governs criticality and energy localization in the cell cytoskeleton - Nature Physics Self-organized criticality can occur in cellular systems, but its origins remain unclear. Now it is shown that cytoskeletal criticality is influenced by the F-actin architecture and myosin active stre...

This piece of work from my PhD is FRESHLY out of the oven in
@natureportfolio.nature.com
Nature Physics! It illustrates how architecture and active stress mutually regulate Criticality and exhibit Anderson Localization-like phenomenon. www.nature.com/articles/s41...

How a discovery in Yellowstone National Park led to the development of PCR - Richmond Scientific A discovery in Yellowstone National Park led to the development of PCR, the gold-standard COVID-19 tests used to fight the global pandemic.

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪
www.richmondscientific.com/how-a-discov...

DNA-guided transcription factor interactions extend human gene regulatory code - Nature A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1
www.nature.com/articles/s41...

Poster for a Royal Society funded workshop on “generative biology” at the interface between synthetic and developmental biology. The workshop is scheduled for 20-21 October 2025, and features the following speakers: Philip Ball, David Brückner, Francesca Ceroni, Jamie Davies, Pulin Li, Mattias Malaguti, Yolanda Schaerli, Ricard Solé, Berna Sozen, Ben Steventon, Jared Toettcher, Vikas Trivedi, Berta Verd, Sara Wickström. Places available for short talks and posters

Can using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷‍♀️🔧

If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology

www.royalsoc.ac.uk/science-even...

Check out our new work!

The code for performing coherent structure analysis, along with the documentation, is available at sreejithsanthosh.github.io/FTLEhub/. Please feel free to reach out if you are interested in using this analysis for kinematic data in your system!

Collective cell migration is fascinating!
Some tissues behave like fluids (motile), others like solids (jammed).

Check out some papers exploring this topic in this thread.

Tissue-like multicellular development triggered by mechanical compression in archaea The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...

Pretty much everything is fucked, but here is some beautiful and exciting science from @archaeon-alex.bsky.social and colleagues.

www.science.org/doi/10.1126/...

Morphogenetic movements reshape cell-cell interaction ranges, quantified as Embryological Light Cones (ELCs). These ELCs are highly different from the corresponding static tissue patterning ELCs.

📣Check out our work led by @alex-plum.bsky.social ! We developed a mathematical framework for morphogen patterning in dynamic tissues, revealing key insights into how morphogenesis mediates cell-cell communication, morphogen compartmentalization and fate coordination. biorxiv.org/content/10.1...

Chuai, M., Serrano Nájera, G., Serra, M., Mahadevan, L., & Weijer, C. J. (2023). Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo. Science Advances, 9(1), eabn5429. https://doi.org/10.1126/sciadv.abn5429 #EpithelialMechanics

Morphometry and mechanical instability at the onset of epithelial bladder cancer Nature Physics - Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are...

Our paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" is now out in
@naturephysics.bsky.social :
rdcu.be/d5rTP

#BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling

Saransh will give the lab's first yeast talk since the birth of our lab at the #ASCB meeting 2024 in San Diego (Dec 14-18). Come to the 'Biological Size Control and Scaling' session this Saturday at 9:30 AM!

"The topology, shape and size of mitochondrial networks during the cell cycle in yeast"

Large-scale collective motion of epithelial cells not as a fluid, but as a polar elastic solid.
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...

This app is so cool!