Bianca Introini

Great work by @tzujingyang.bsky.social and @melaniemcdowell.bsky.social!!

This photograph captures Sir David Attenborough seated outdoors on the rugged terrain of Skomer Island. Behind him, the ocean and coastal cliffs form a scenic backdrop under a clear sky. Sir David, dressed in a khaki jacket and light trousers, looks towards the camera with a gentle expression, exuding a sense of warmth, calm, and wisdom. Around him, puffins can be seen flying and perched on the rocky ground, illuminated in rays of golden sunlight as the sun sets behind the cliffs.

Happy 99th birthday to the man who gave voice to the wild. 🎉

Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.

You've inspired generations to fall in love with nature.

Super excited to share this as my first post with the 🦋 world! In my first co-correspondent article, we (@Mayra Borrero @Agnieszka Chacińska @IMOL Institute) look at the roles of lipids in mitochondrial protein import complexes (spoiler: there are plenty!) &call for methods (spoiler: there are few!)

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

PDB101: Browse: HIV and AIDS PDB-101: Training, Outreach, and Education portal of RCSB PDB

After the start of the AIDS epidemic, scientists revealed the atomic structures of the molecules in HIV, helping to design treatments
Explore how PDB structures help our understanding of HIV at PDB-101 #CROI2025 pdb101.rcsb.org/brow...
Images are free for use

DIC and cryo-ET images of G1 and G0 fission yeast cells.

Zhi Yang Tan & @shujuncai.bsky.social's comparative study of G0 (quiescent) and interphase fission yeast cells is out in @jcellsci.bsky.social doi.org/10.1242/jcs.263654. This study combines multiple cell-biological analyses with in situ cryo-ET. Raw data: www.ebi.ac.uk/empiar/EMPIAR-10339

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...

We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

Cellpose3: one-click image restoration for improved cellular segmentation - Nature Methods Cellpose3 employs deep-learning-based approaches for image restoration to improve cellular segmentation and shows strong generalized performance even on images degraded by noise, blurring or undersamp...

It turns out this works well for improving segmentation, and Cellpose3 offers a general solution for many segmentation tasks. Please see the full paper for all the details. www.nature.com/articles/s41...

Improvements in LM (top) and EM (bottom) of our micro-sam model (finetuned) compared to the default SAM model.

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...

Hot from the press for #CellMigration + #Nucleus aficionados

Karling @helenweavers.bsky.social lab show *in vivo* how immune cell adapt quickly to confined microenvironments during motility.

Live-cell imaging, image analysis, #Drosophila !

Full @emboreports.org
www.embopress.org/doi/full/10....

These days at EMBL in Heidelberg for the EMBO Workshop “In situ structural biology: expanding the toolbox for structural cell biology” were amazing!
I showed my work on the tetrameric serotonin receptor:

www.embopress.org/doi/full/10....

#EMBOinsitu

#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules

#Cancer cells switch strategies during metastasis to invade other tissues

Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social

Thank you Ulja! See you tomorrow in Heidelberg!

Thank you so much Alexey! 🙏🏻🍃

Thank you Oli!!!🍀❄️

Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea - Nature Structural & Molecular Biology Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interacti...

I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...