Chris Parker

Discovery of a tau-aggregate clearing compound that covalently targets P4HB The improper folding and aggregation of tau are linked to several neurodegenerative diseases affecting millions worldwide. However, the pathogenesis o…

Check out our recent collaboration with @abbvie.bsky.social in @cp-cellchembiol.bsky.social. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation).

Happy to share the finalized version of this work out in @angewandtechemie.bsky.social.

onlinelibrary.wiley.com/doi/10.1002/...

Targeted Protein Acetylation Through Chemically Induced Proximity ConspectusProtein acetylation is a pervasive and reversible post-translational modification (PTM) that impacts various protein features including stability, localization, and interactions and regulate...

Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation.

Nice work Wesley and Roy!

pubs.acs.org/doi/10.1021/...

Benjamin Cravatt awarded Tetrahedron Prize for Creativity - Scripps Research Magazine Benjamin Cravatt, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, will receive the 2025 Tetrahedron Prize for Creativity in Bioorganic and Medicinal Chemistry. Established in ...

Congrats to Benjamin Cravatt on receiving the 2025 Tetrahedron Prize for Creativity in Bioorganic & Medicinal Chemistry from @elsevierconnect.bsky.social, honoring his pioneering activity-based protein profiling (ABPP) to study and target disease-relevant proteins.

Post-Translational Modifications Remodel Proteome-Wide Ligandability Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Probing the proteome - Nature Biotechnology Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?

“Probing the proteome”

www.nature.com/articles/s41...

A big congratulations to the newly minted Dr. Forrest @inesforrest.bsky.social. Super proud! A big thanks to her committee members @michael-erb.bsky.social @wisemanlab.bsky.social @fleurmferguson.bsky.social @shenvi.bsky.social

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...

Beyond thrilled to share that my PhD work is now available as a preprint! 🥳 A huge thank you to my amazing colleagues, mentors and collaborators at @scripps.edu and @abbvie.bsky.social who supported and contributed to this project!

😎

The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social

Looking forward to catching up!

We designed a library of function-biased, target agnostic bifunctional molecules and profiled them proteome wide for their ability to degrade proteins. We believe this study provides a proof of concept to expand PROTAC strategies beyond targets with well-established ligands.

Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among ...

Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @inesforrest.bsky.social

www.biorxiv.org/content/10.1...

Congratulations!!!

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...

🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...

Opinion: Science funding cuts are based on flawed logic. Here’s the truth. Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…

OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs."
www.sandiegouniontribune.com/2025/02/25/o...

I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….

🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.

If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩‍🔬

Congrats Brian and team!!!

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes

chemrxiv.org/engage/chemr...

Insightful perspective by the group of Ben Cravatt with first author @xiaoyuzhang.bsky.social in @nchembio.bsky.social. They discuss reasons, why expanding the repertoire of E3s for TPD has converged on few "frequent hitters" and how additional E3 targets could be identified. doi.org/10.1038/s415...

Congrats Ben!!!