Lara Goscé

Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...

In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...

The potential impact, cost and cost-effectiveness of tuberculosis interventions - a modelling exercise Background While a range of interventions exist for tuberculosis prevention, screening, diagnosis, and treatment, their potential population impact and cost-effectiveness are seldom directly compared,...

At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings?

📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n

bit.ly/3V3vXth

U.S. issues sanctions against United Nations investigator probing abuses in Gaza The State Department's decision to impose sanctions on Francesca Albanese, the U.N. special rapporteur for the West Bank and Gaza, follows an unsuccessful campaign to force her removal.

The State Department's decision to impose sanctions on Francesca Albanese, the U.N. special rapporteur for the West Bank and Gaza, follows an unsuccessful campaign to force her removal.

Secretary of State Marco Rubio has imposed sanctions on Francesca Albanese, the U.N. special rapporteur on the occupied Palestinian territory.

Albanese says the move is an effort to “distract” from the genocide in Gaza.

New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood.

www.thelancet.com/journals/lan...

Figure 1. Estimated number of trial endpoints in the control group of a prevention-of-disease vaccine trial in a high disease-burden setting showing number of endpoints on the y-axis and time in months on the x-axis. For bacteriologically confirmed symptomatic tuberculosis disease endpoints only, we estimate 69 endpoints, and for combined bacteriologically confirmed asymptomatic and symptomatic tuberculosis disease endpoints, we estimate 151 endpoints. Scenario assumes symptomatic disease incidence before trial screening of 300/100 000 per year and following 10 000 individuals over 3 years. Prevalent symptomatic and asymptomatic tuberculosis disease are screened out in month 0 and are not trial endpoints. Active screening occurs every 6 months for both scenarios and participants self-presenting with symptoms suggestive of tuberculosis disease would also be investigated.

In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.

doi.org/10.1016/S221...

@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social

A study in the Lancet recently looked at the cumulative impact of reductions in American aid. It found that, by 2040, 8 million more children will die before their fifth birthday. b-gat.es/44wCCQO

The facts are simple and devastating: Aid cuts have already cost lives, and the number of deaths will continue to rise. Here’s the evidence. ​

Palestinians fleeing northern Gaza on 9 November 2023 amid Israel's bombardment and siege of the enclave, and intense fighting between the Israeli military and Hamas fighters in the north. Credit: Mohammed Zaanoun/TNH

LSHTM's Director writes to UK Government about #Gaza public health catastrophe

Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:

👉 www.lshtm.ac.uk/newsevents/n...

25th anniversary celebrations of the Introduction to Infectious Disease Our special event will celebrate the 25th anniversary of the Introduction to Infectious Disease Modelling and its Applications course, delivered by the London School of Hygiene & Tropical Medicine

Can you believe it’s already been 25 years!?

Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!

More info 👉 www.lshtm.ac.uk/newsevents/e...

Tuberculosis and climate change: analytical framework and knowledge gaps This report explores the intersection of tuberculosis (TB) and climate change, highlighting how climate-related challenges such as food and water insecurity, displacement, and disrupted healthcare acc...

TB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...

Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.

Postdoc (London, UK)
Position available in the world-leading tuberculosis (TB) Modelling group at LSHTM
with @raclark18.bsky.social‬ @richardwhite321.bsky.social
at LSHTM @lshtm-tbmod.bsky.social
More details: http://iddjobs.org/jobs/2314

Tuberculosis and the climate crisis in Latin America: a predicament of poverty, migration and displacement Tuberculosis (TB) has long been associated with poverty and displacement, through food insecurity, overcrowding, poor living conditions and reduced access to healthcare, which significantly increase t...

Climate-driven migration and displacement and their potential impact on TB in Latin America gh.bmj.com/content/10/4... @cfmcquaid.bsky.social @reinhouben.bsky.social @lshtm-tbmod.bsky.social

Climate change and tuberculosis: an analytical framework Climate change is likely to exacerbate a range of determinants which drive tuberculosis, the world's leading infectious disease killer. However, tuberculosis is often neglected in wider climate health...

Climate change is likely to exacerbate determinants which drive TB, the world’s leading infectious disease killer. Commissioned by WHO, we developed an analytical framework outlining potential causal relationships between climate change and TB:
medrxiv.org/cgi/content/...
@lshtm.bsky.social @who.int

Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine on FindAPhD.com PhD Project - Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine, listed on FindAPhD.com

Three PhD opportunities in modelling at @lshtm.bsky.social and @ukhsa.bsky.social on:
Homelessness/Housing and TB: shorturl.at/FJ57W
EBV and cancers in the UK: shorturl.at/IRHJk
Climate change and TB: shorturl.at/R7f50

PhD position (London, UK)
Quantify the effects of climate change on TB
with @cfmcquaid.bsky.social @reinhouben.bsky.social @laragosce.bsky.social
at @cmmid-lshtm.bsky.social @tb-lshtm.bsky.social @lshtm.bsky.social
More details: http://iddjobs.org/jobs/2253

New PhD opportunity at LSHTM @lshtm.bsky.social @cmmid-lshtm.bsky.social and UKHSA
www.lshtm.ac.uk/study/fees-a...

Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam: a mathematical modelling study Background Population-wide screening may accelerate the decline of tuberculosis (TB) incidence, but the optimal screening algorithm and duration must weigh resource considerations. Methods We calibra...

1/ 📢 In our new PREPRINT - tinyurl.com/2pmudzrk - we evaluate how symptom-agnostic, population-wide screening interventions could significantly reduce the TB burden in Viet Nam. These require a substantial front-loaded investment but yield lasting cost savings. 🧵 #Tuberculosis #TBSky

Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia Background Digital adherence technologies (DATs) with associated differentiated care are potential tools to improve tuberculosis (TB) treatment outcomes and reduce associated costs for both patients a...

Our ASCENT modelling paper on Digital Adherence Technologies (DAT) for TB treatment is now out in BMJ Global Health gh.bmj.com/content/9/12... DATs may have limited epidemiological impact but can reduce costs and have important budgetary implications. @cfmcquaid.bsky.social @lshtm-tbmod.bsky.social

Reflecting on this year’s #TB #UnionConf2024 and am so inspired by the brilliant minds and groundbreaking research being done to combat this global health threat. Special shoutout to the TB Modelling Group @lshtm.bsky.social 🫁