Genomes & Genetics

Identification and characterization of thousands of bacteriophage satellites across bacteria Abstract. Bacteriophage–bacteria interactions are affected by phage satellites, elements that exploit phages for transfer between bacteria. Satellites can

And for those interested, there is a computational tool to find them made by @jmouradesousa.bsky.social satelliteFinder doi.org/10.1093/nar/... available at galaxy.pasteur.fr/root?tool_id.... Look out for v2!

Phage satellites are now known to be very diverse, numerous and ancient. They pose many evolutionary, ecological and mechanistic questions. Lots of fun in perspective!
Great pleasure to write this review to show it, with @jrpenades.bsky.social @dbikard.bsky.social Kim Seed & John Chen.

Call for applications 2025 - Creation of new research groups at the Institut Pasteur - Research The Institut Pasteur launches an international call to recruit new junior research group leaders in the application of cutting-edge transdisciplinary approaches to the exploration of host-microbe, tis...

Two more weeks to apply to join us in Paris !
research.pasteur.fr/en/call/call...

Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇

Prédire l’organisation et l’activité d’un ADN étranger dans une cellule hôte Les transferts d’ADN d’une espèce à une autre sont des événements fréquents et naturels.

#RésultatScientifique🔎 Quand un ADN étranger s'intègre dans une cellule hôte, comment s’adapte-t-il aux règles métaboliques de son nouvel occupant ? @rkoszul.bsky.social et ses collaborateurs ont enquêté ! 🕵️

🤝 @cnrs.bsky.social @pasteur.fr @mnhn.fr

https://buff.ly/40GvJL2

Here's a project with surprising results: we show the presence of virulent phages across bacterial genome assemblies. Not any phage, and not your typical T1 contaminant, many phages have large genomes and seem to be in a state of persistence/oscillation (?!) between lysogeny and the lytic cycle.

Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons Nature Microbiology - Structural and phylogenetic analyses show that programmable RNA modifications ubiquitous in archaea and eukarya arose from bacterial transposons.

🦠Bacteria serve as an amazing reservoir of immune genes for eukaryotes but also of essential cellular functions!

⬇️New exaptation example : euk RNA-guided RNA modification originated from "bridge RNA" IS110 transposons.

Led by @hugovaysset.bsky.social and C. Meers from Sternberg lab! rdcu.be/d5ovZ

The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌

🚨Postdoc position(s) alert🚨 If you like to develop new bioinformatic tools for *human* microbiome analysis, are interested by virus/phages, we (JGI Viral Genomics and Microbiome Data groups) may have a great position for you ! No official job posting yet, but email or DM if you are interested !

@epcrocha.bsky.social

Follow us for news from teams @audeber.bsky.social @rkoszul.bsky.social @amazeld.bsky.social, waiting for Eduardo Rocha, Lluis Quintana-Murci, Nicolas Rascovan, Camille Berthelot, Charles Baroud, Benoit Arcangioli, Xavier Montagutelli

The department of Genomes and Genetics at Institut Pasteur on Bluesky !
Exploring the genomes and communities of bacteria, yeast, and humans to shed new lights on their genetics, function, and evolution.