Sebastian Siegner

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

21.05.2025 15:27 — 👍 85    🔁 34    💬 8    📌 1

Treatment of a metabolic liver disease in mice with a transient prime editing approach - Nature Biomedical Engineering A transient in vivo prime editing strategy is developed for the liver by delivering the prime editor as mRNA encapsulated in LNP.

Our paper describing an RNA-LNP prime editing strategy for treating phenylketonuria was published today in Nature Biomedical Engineering (1/7)
www.nature.com/articles/s41...
@schwanklab @UZH_Science @UZH_en @KispiZuerich @ethz.ch

20.05.2025 09:08 — 👍 4    🔁 4    💬 1    📌 0

Exciting PhD project available in our lab (time sensitive)! 👇

07.05.2025 12:10 — 👍 10    🔁 15    💬 1    📌 0

Comprehensive interrogation of synthetic lethality in the DNA damage response Nature - Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in...

Thrilled to see this “veritable tour de force” led by John_C_Fielden from Jacob Corn lab out @nature.com, rdcu.be/ehd4E. This @erc.europa.eu funded project uses #CRISPRi to systematically scan 548 DDR genes for synthetic lethal interactions, ~150,000 pairwise combinations!

14.04.2025 10:22 — 👍 10    🔁 5    💬 1    📌 0

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...

12.02.2025 16:00 — 👍 34    🔁 22    💬 2    📌 1

Very cool study about selective protein degradation by FBXO31!

29.01.2025 17:53 — 👍 3    🔁 1    💬 0    📌 0