Sebastian Siegner

Validate User

Happy to share our latest research on the BRCA1-BRCTs now online.

academic.oup.com/nar/article/...

Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.

18.09.2025 08:40 — 👍 19    🔁 6    💬 1    📌 1

Mitotic single-stranded DNA suppression by DDIAS Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

New work from the lab! 🔬

We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n

www.biorxiv.org/content/10.1...

10.09.2025 16:50 — 👍 47    🔁 17    💬 2    📌 0

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

28.08.2025 06:34 — 👍 129    🔁 166    💬 0    📌 6

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

27.08.2025 16:14 — 👍 304    🔁 109    💬 14    📌 11

Exciting times ahead!

Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.

18.08.2025 14:54 — 👍 66    🔁 9    💬 10    📌 1

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

13.08.2025 15:44 — 👍 81    🔁 32    💬 3    📌 3

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

21.05.2025 15:27 — 👍 87    🔁 34    💬 8    📌 1

Treatment of a metabolic liver disease in mice with a transient prime editing approach - Nature Biomedical Engineering A transient in vivo prime editing strategy is developed for the liver by delivering the prime editor as mRNA encapsulated in LNP.

Our paper describing an RNA-LNP prime editing strategy for treating phenylketonuria was published today in Nature Biomedical Engineering (1/7)
www.nature.com/articles/s41...
@schwanklab @UZH_Science @UZH_en @KispiZuerich @ethz.ch

20.05.2025 09:08 — 👍 5    🔁 4    💬 1    📌 0

Exciting PhD project available in our lab (time sensitive)! 👇

07.05.2025 12:10 — 👍 10    🔁 15    💬 1    📌 0

Comprehensive interrogation of synthetic lethality in the DNA damage response Nature - Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in...

Thrilled to see this “veritable tour de force” led by John_C_Fielden from Jacob Corn lab out @nature.com, rdcu.be/ehd4E. This @erc.europa.eu funded project uses #CRISPRi to systematically scan 548 DDR genes for synthetic lethal interactions, ~150,000 pairwise combinations!

14.04.2025 10:22 — 👍 10    🔁 5    💬 1    📌 0

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage.
doi.org/10.1101/2025...

12.02.2025 16:00 — 👍 34    🔁 22    💬 2    📌 1

Very cool study about selective protein degradation by FBXO31!

29.01.2025 17:53 — 👍 3    🔁 1    💬 0    📌 0