jake

Leading a lab, and all it entails A chemist offers actionable leadership advice to principal investigators

Feeling awed and a bit starstruck that @science.org chose to run a book review on #LabworkToLeadership!!
www.science.org/doi/10.1126/...

Covalently constrained ‘Di-Gembodies’ enable parallel structure solutions by cryo-EM - Nature Chemical Biology Disulfide-based dimerization of modified identical and heterologous nanobody scaffolds enables higher-order assembly for high-resolution cryo-electron microscopy structure determination that is widely...

Di-Gembodies (dimerized nanobodies) for improved and duplexed CryoEM of small and challenging targets!

A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social

Out now in Nature Chemical Biology @natchembio.nature.com

www.nature.com/articles/s41...

The 15th international symposium on proteomics in the life sciences Aug. 17–21, 2025 | Cambridge, Mass.

ASBMB's symposium on #proteomics in the life sciences starts on Sunday! What topics are you most excited to learn about? Reply to let us know!
ow.ly/8aJ850WGoTr
Thank you to our sponsors, including: @biognosys.bsky.social, @abseabio.bsky.social, @evosep.bsky.social & @mobilionsystems.bsky.social!

Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology - Nature Communications Traditional genetic perturbation tools such as siRNA and CRISPR knockout operate on timescales that render them unsuitable for exploring dynamic processes or studying essential genes, where chronic de...

www.nature.com/articles/s41...

An elegant study to use CRISPR technology to optimize the auxin-inducible degron technology

Some interesting observations using the superior degron technology

@natureportfolio.nature.com @nufeinbergmed.bsky.social

📣 First ever international ubiquitin meeting in Australia www.lorneubiquitin.org still accepting abstracts and registrations! Hopefully we can get more people in the Asia-Pacific!
#science #conference #scicomm #Australia

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org
#ubiquitin

It's been a wild 3.5 years for Philipp, always a pleasure witnessing Philipp's dedication and his journey in the @komanderlab.bsky.social tackling DUB biology in cancer during his PhD journey here @wehi-research.bsky.social

#ubiquitin #science #PhDlife #PhD

Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...

A Perspective from Xiaoyu Zhang, Gabriel Simon, and Benjamin Cravatt discusses recent strategies to expand the E3 ligase landscape and the scope of targeted protein
degradation

www.nature.com/articles/s41...

So nice to see @franciscobustos.bsky.social in person this time as a PI

Nice to catch up and see amazing stuff from your lab

More importantly this person remembered me from a dark background while being online in Australia in 2020 but so ashamed I didn't remember #cshlubiq

This meeting has a piano performance #cshubiq @cshlmeetings.bsky.social

A take on the ubiquitin code #cshlubiq @jnpruneda.bsky.social really like the clarity and introduction to this talk

Whom would you like to hear at our next event?

The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale.

Let us know in reply to this post, whom you would additionally like to hear!

SAVE THE DATE 🗓️Ubiquitin & Friends Symposium: 8-9 May 2025 in Vienna!
Registration will open🔜 Keep an eye out for the announcement 👀
✨guest speaker lineup👇🧵 +talks from abstracts! Great chance for #ECRs to meet with peers & experts in a friendly setting!
🔗 www.protein-degradation.org/symposium/

We are looking for your input!

Whom would you like to hear next to @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale at this year's @chembiotalks.bsky.social?

🚨 The #Ubiquitin Congress is back in Würzburg! 🚨
Excited to host it again, June 2-4, 2025! 🌟

✨ Still time to submit your abstract for a Short Talk!

🗓️ Registration Deadline: March 1st
📝 Abstract Submission Deadline: April 15th

Don’t miss out—register now!
➡️ www.ubiquitin-wuerzburg-2025.de

Join us tomorrow, January 28, for an exciting @crc1430.bsky.social seminar at @unidue.bsky.social ! We’re happy to welcome Sascha Martens @maxperutzlabs.bsky.social @univie.ac.at, who will present on "Mechanisms of Selective Autophagy."

Congratulations to @alesalerno.bsky.social from University of Dundee CeTPD and Christine Ng from @stanford-chemh.bsky.social who have been selected as recipients of our conference travel scholarships to attend the Proximity-based Therapeutics Keystone conference @keystonesymposia.bsky.social!

PROTAC protein degraders to drug the undruggable enter phase 3 trials Pharmaceutical companies are investing in therapies that target proteins for degradation, with trials ongoing for cancer, autoimmune diseases and neurological disorders.

www.nature.com/articles/d41...

Intriguing - do we need to always move overseas for a postdoc for a successful career track?

Now online - the Feature Review "Protein N-terminal modifications: molecular machineries and biological implications" from @natmachinery.bsky.social and colleagues.

#Acetylation #Methylation #Myristoylation #Ubiquitylation #Oxidation #Arinylation

authors.elsevier.com/sd/article/S...

Line charts showing decline in cardiovascular disease death rate since 1950 in the US, France, UK and Italy.

Cardiovascular disease mortality has declined in many countries over the past decades.

For example, US cardiovascular disease death rates have declined 4x since 1950.

How many Ps can one add to a protein?

For the innate immunity crowd all things DNA-sensing related

Bringing the STING crowd together in one list!

A starter pack to follow for sure #metabolism

For all the lovers of membrane proteins and lipids! what a list!

Ubiquitinists to follow!

Very cool list!

E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat | EMBO reports imageimageFBXW7 regulates brown fat expansion and thermogenesis by targeting S6K1 for ubiquitination and degradation, which impacts glycolysis and brown preadipocyte proliferation via lactate. FBXW7 ...

www.embopress.org/doi/full/10....

Genetic variant of FBXW7 leads to studies in mice showing removal of FBWX7 in adipose tissue leads to counteracting obesity in mice - FBXW7 in this study ubiquitinates S6K1, a downstream protein of mTOR

#ubiquitin #science #biology

Another mega E3 ligase with intriguing structural insights

Structure highlighting the targeting of a myriad of possible substrates by UBR4 alongside KCMF1 co-factor (not E3 ligase in my view for many years)

#ubiquitin #science #literature #biology

Pellino 3 E3 ligase promotes starvation-induced autophagy to prevent hepatic steatosis PELI3 regulates starvation-induced autophagy and safeguards liver homeostasis by controlling protein and lipid turnover.

www.science.org/doi/10.1126/...

PELI3 regulates lipid and autophagy homeostasis - study suggests links between PELI3 deficiency and hepatic steatosis

#science #literature #metabolism #health