Explore RNA's role in epigenetics, DNA repair, transcription & genome organisation - directly with leaders from academia & industry at #GenReg26!

Remaining talks to be filled from submissions - register & submit by 04 Sep 2025 to join us in Mexico.

Speakers, details & registration➡️ bit.ly/46JQbze

17.07.2025 12:12 — 👍 7    🔁 7    💬 1    📌 0

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

24.05.2025 11:12 — 👍 48    🔁 18    💬 4    📌 1

The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states Gupta et al. showed that NPM1, a nucleolar granular component factor, mediates NAD association with the nucleolus. NPM1 binds NADs and recruits histone methyltransferase G9a to establish H3K9me2 repressive chromatin, revealing that the nucleolus functions not only as a scaffold for NADs but also actively contributes to their chromatin repression.

Online Now: The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states Online now:

23.05.2025 22:57 — 👍 11    🔁 4    💬 0    📌 2

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

21.05.2025 15:27 — 👍 85    🔁 34    💬 8    📌 1

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...

21.05.2025 18:59 — 👍 73    🔁 29    💬 2    📌 0

Predicting gene expression from DNA sequence using deep learning models Nature Reviews Genetics - Barbadilla-Martínez et al. review recent progress in deep-learning-based sequence-to-expression models, which predict gene expression levels solely from DNA sequence....

Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.

17.05.2025 07:30 — 👍 19    🔁 7    💬 0    📌 0

Very happy to share the peer-reviewed version of our paper in which we study the formation and function of pair-wise and multi-way enhancer-promoter interactions in gene regulation (see thread below): www.nature.com/articles/s41...

13.05.2025 09:41 — 👍 102    🔁 33    💬 3    📌 3

The EMBL conference '#Chromatin & #Epigenetics' opens today!
Organized by
🌟Asifa Akhtar @mpi-ie.bsky.social
🌟Amanda Fisher @ox.ac.uk
🌟Bing Ren @ucsandiego.bsky.social
🌟Dirk Schübeler @fmiscience.bsky.social

Looking forward to an exciting meeting!

@events.embl.org #EMBLChromatin

13.05.2025 08:19 — 👍 21    🔁 5    💬 0    📌 1

Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...

Very excited to share our latest work revealing a prominent role for LADs in commisioning cell fates in mouse organ & tissue development, particularly of the limb. Amazing work by Isabel and Samy together with @stemundi.bsky.social & @drmrobson.bsky.social
www.biorxiv.org/content/10.1...

08.05.2025 09:18 — 👍 16    🔁 5    💬 0    📌 0

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates Without surveillance, errors in ribosome assembly can lead to the buildup of defective intermediates that impair protein production. Akers et al. developed a system to model faulty ribosomes in human cells and discovered that the protein ZNF574 targets these intermediates for degradation. Loss of quality control results in defective ribosome buildup that jeopardizes cellular homeostasis and organismal health.

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07.05.2025 11:32 — 👍 5    🔁 4    💬 0    📌 0

Exciting PhD project available in our lab (time sensitive)! 👇

07.05.2025 12:10 — 👍 10    🔁 15    💬 1    📌 0