Henrik Salje

Heterogeneity in inhibition of genetically diverse dengue virus strains by Wolbachia The release of Aedes aegypti mosquitoes transinfected with the virus-inhibiting Wolbachia bacterium has the potential to reduce the burden caused by dengue virus (DENV). However, the robustness of thi...

📢New preprint on the impact of dengue virus genetic diversity on inhibition by Wolbachia 🦟🦠🧬

Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨

Key findings in thread below 👇

www.biorxiv.org/content/10.1...

🧵 Our paper out today in @naturemedicine.bsky.social

www.nature.com/articles/s41...

On development of #StrepA #Immunity over life course in #TheGambia raising hope for #vaccines on the horizon

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#Immunosky #IDsky #MicroSky #globalhealth.

A One Health approach to understanding and managing Nipah virus outbreaks - Nature Microbiology In this Perspective, Yadav et al. discuss NiV outbreaks, transmission cycles and the role of reservoir and bridging hosts. They also discuss a One Health approach to mitigate the risks of NiV epidemic...

🚨 Nipah virus poses a future #pandemic risk. New cases in Kerala, India further highlight the need for a One Health approach. Read more in our recent interdisciplinary and multi-institutional collaborative article now published in @NatureMicrobiology #LZCI : www.nature.com/articles/s41...

RSero: A user-friendly R package to reconstruct pathogen circulation history from seroprevalence studies Author summary Antibodies are immune markers of past infections. Seroprevalence studies that characterize the seropositivity status in the population have been used for decades in epidemiological stud...

Serological data provide key insights on pathogen circulation. We introduce a new R package, Rsero, which is a pipeline to store and analyze age-stratified sero data, estimate the history of pathogen circulation and compare different transmission models.
journals.plos.org/ploscompbiol...

Phylowave; The latest framework developed by researchers to identify more infectious variants of viruses or bacteria, including those responsible for flu, #COVID and whooping cough.

"A vaccine can be specifically targeted against these variants, to make it as effective as possible"
🔗 rdcu.be/d5pFu

Great way to start the year! A paper in @nature.com by our amazing @noemie presenting a way to use sequences to identify pathogen lineages, quantify their fitness, and identify potentially important genes/snps . Works across bugs, even with minimally and biased set of sequences.

Great way to finish the year! Paper by our @huangat.bsky.social in @pnas.org showing that relying on seroconversions in cohorts will usually lead to horribly biased #dengue incidence estimates whereas models relying on age data from local hospital typically robust.

Really excited by the creation of this new Unit with @ksbakes.bsky.social and @virologyhouldcroft.bsky.social working on the emergence, spread and control of infectious diseases at the University of Cambridge

Huge thanks to my supervisors Katie Hampson and Christina Cobbold, examiners @davidlrobertson.bsky.social and @hsalje.bsky.social and convener Louise Matthews!! And everyone else at UofG and beyond who have made the last 3.5 years an amazing time 😁🎉

We are very proud to share that @hsalje.bsky.social has been awarded an #ERC Consolidator Grant 🎉

He will be exploring how host, immunity and mosquito factors combine to determine the evolving fitness of the #dengue virus 🦠

Could not be more deserved. Congratulations again Noémie.

Dynamics of measles immunity from birth and following vaccination - Nature Microbiology Measles remains a major threat to human health despite widespread vaccination. While we know that maternal antibodies can impair vaccine-induced immunity, the relative contributions of pre-existing im...

#Measles antibody dynamics are highly predictive. Knowing only a future mum’s titre, we can predict how the infant will respond to vaccine much later. We also see vaccine failure linked to csection birth - maybe due to way microbiome develops. Important these infants get 2nd dose t.co/MqxTtuIHTH

Dynamics of measles immunity from birth and following vaccination - Nature Microbiology Serological data modelling informs on immune interference from maternal antibodies on measles vaccine responses in infants and children.

New work led by Wei Wang characterises the dynamics of measles immunity in infant&child cohorts in China. @hsalje.bsky.social www.nature.com/articles/s41...

Congratulations to our amazing DR. Megan O’Driscoll @meganodris.bsky.social on successfully passing her PhD viva! State of the art in infectious disease serology. Thank you to Michael White and Stephen Baker for being excellent examiners.

We’re hiring!! postdoc and research assistant (with potential for PhD) positions on mathematical modeling of infectious diseases at Cambridge (UK). Mainly of arboviruses including with longitudinal cohorts, disease mapping and models applied to multiplex serology in Africa. jobs.cam.ac.uk/job/44461/

Excited to present our poster on the genetic diversity of Nipah virus later today at Epidemics9 - Come say hi at poster P2.167! 🦇🧪#EpiSky @hsalje.bsky.social

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting - Nature Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multi...

🧪Yup. Looks like you can atone for original antigenic sin. As with all learning, repetition is key 🥲 (The sky ain’t falling. Imprinting is real, but reports of the immune system’s demise were premature.) h/t @thelonevirologist.bsky.social www.nature.com/articles/s41...

The evolution and international spread of extensively drug resistant Shigella sonnei - Nature Commun... An increase in shigellosis cases among men who have sex with men in the United Kingdom has been linked to an extensively drug-resistant strain of Shigella sonnei. In this genomic epidemiology study, t...

The evolution and international spread of extensively drug resistant Shigella sonnei. The international outbreak (England, France, Belgium, USA, Australia) was ciprofloxacin, azithromycin, and ceftriaxone resistant - three of four WHO recommended antibiotic treatment options for shigellosis. 🖥️🧪🧬🦠🧫