Lydia Daboussi

As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway.
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Cute calendar!! ☀️

BIG FIGHT AT POLAND’S WROCLAW ZOO!!!

your second moment of calm

We are hiring new faculty!! Come join our amazing community in the Department of Molecular Microbiology at Washington University School of Medicine! The deadline for applications is 2/21, but applications will be reviewed on a rolling basis. facultyopportunities.wustl.edu/Posting/Deta...

Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇

Congratulations Chris! Exciting story!

awesome resolution!

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...

Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

Huge shoutout to all the NIH scientific review officers and external academics who stepped up after the government shutdown to help reschedule hundreds of study sections. Thanks to this great community, my fellowship review was rescheduled within two months of its original review date 🧪

This--my SRO and her colleagues are doing heroic work AND keeping me informed--THANK YOU!

Evolution of taste processing shifts dietary preference - Nature Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...

Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...

Also, I aliquot into 20-50ul and then freeze thaw. I haven't noticed issues with that (but also I don't freeze thaw more than a couple of times).

For yeast and bacteria I used it at 1:100, and that seemed to work well. I noticed that for mouse tissue it needs to be more concentrated.

It's supposed to be 200X, but for yeast and bacteria I treated it like 100X. When I use mouse tissue I use it a little more concentrated (some slight differences in concentration depending on which mouse tissue)

I've used this one since the yeast days. I freeze aliquots at -20 when I receive it. Ihttps://www.sigmaaldrich.com/US/en/product/sigma/p8340?srsltid=AfmBOoqGoHf_0TMrlS4hlQKjEOiQ9cbNeK261BYVt96d1ccKBKHkj1lA

What are you currently using?

@drugmonkey.bsky.social timely.

thanks

How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.

cell.com/immunity/ful...

Thanks and congratulations to all contributors

New tenure track faculty position in glia and/or neurovascular coupling! Please come join us!

academicjobsonline.org/ajo/jobs/30864

#neurosky #neuroskyence #glia #neurojobs

It’s so exciting to see this. These tools will be game changing.

If you think your field needs a collection of curated reviews and protocols, let me know! Let's create it and help the community.

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social

We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.

Wow! This is really exciting!

UCLA research is amazing ✨✨

newsroom.ucla.edu/stories/ucla...

🚨
New Preprint!
Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons.

▶️ www.biorxiv.org/content/10.1...

I would love to be added if there is still space :)

Hi! I would love to join if there is still space :)