Jakub Rohlena

Uridine Uridine is a pyrimidine nucleoside composed of an uracil base and a ribose sugar. In cells, uridine is predominantly present in RNA (as uridine monophosphate, UMP). Uridine can be produced through de ...

Uridine: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

a great not-to-miss piece from the @lyssiotislab.bsky.social

📢🚨Deadline to submit an abstract for the 2025 Showcase is this Friday, March 21st!📢🚨

Registration free!
Speakers chosen from abstracts and non-faculty only!
Amazing poster session and workshops!

Sign up today at: www.cancermetabolismshowcase.org

Intratumour oxidative hotspots provide a niche for cancer cell dissemination Nature Cell Biology - Ueda et al. develop a sensor targeted to tumour cells that tracks extracellular H2O2. Tumour cells in H2O2 hotspots undergo partial epithelial–mesenchymal transition and...

rdcu.be/edFdJ

🚨 New preprint available! Third and final in the #CRISPR screen series!🚨

👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis

www.biorxiv.org/content/10.1...

By A. Strefeler in collaboration with Dave Pagliarini and team.

@DIB_UNIL @FBM_UNIL

🧵 1/9

Defining the metabolism of SDH-deficient tumours – a bedside to bench approach towards new biomarkers and therapies at University of Birmingham on FindAPhD.com PhD Project - Defining the metabolism of SDH-deficient tumours – a bedside to bench approach towards new biomarkers and therapies at University of Birmingham, listed on FindAPhD.com

Exciting 4-year PhD opportunity in my group, available from October this year! See rb.gy/7p0syj for details. Come and join an exciting research group to study some really cool aspects of metabolism. Please see advert below for details, including contact details and eligibility criteria.

The abstract deadline for #EACR2025 is fast approaching!

Don't miss the exciting opportunity to showcase your research to other attendees in numerous ways, including being featured in the main programme through proffered paper presentations.

You have until 06 March: 2025.eacr.org

An organism-level quantitative flux model of energy metabolism in mice Mammalian tissues feed on nutrients in the blood circulation. At the organism level, mammalian energy metabolism is comprised of the oxidation, storag…

Happy to share the final version of this work where we incorporated isotope labeled CO2 data into mass spectrometry based flux analysis, resulting in a flux model that depicts at the whole-body level functioning of energy metabolism in health and disease.
www.sciencedirect.com/science/arti...

Really interesting and thought-provoking work, Lucas, cool use of your new sensor :-)

Next, our 2nd preprint of the week (!), this one driven by @madelouhart.bsky.social

Previously: Mitochondrial inhibition impairs cell proliferation by constraining aspartate (ASP) availability.

Here: we investigate the kinetics of ASP depletion/ proliferation impairments and...surprises ensue!

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:

A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.

Schedule of speakers at the 2025 FASEB Ferroptosis conference

Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩
shorturl.at/QA6T1

🚨 We're hiring! A 2.5-year (full-time) #Postdoc position available in my lab @uebscimuni.bsky.social in Brno, Czechia. 👇 Apply now & join us to study mitochondrial synthetic lethality in MYC-driven tumors. 📅 Deadline: 21 March 2025. (official e-application link will follow)

Please repost 💚

We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎

Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White

Rhodoquinone carries electrons in the mammalian electron transport chain Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal el…

Congratulations to Jessica Spienelli and her lab for the groundbreaking work.

www.sciencedirect.com/science/arti...

Mark your agendas for the 2nd ISEH mini-symposium organized by the Junior Faculty Committee! Submit an abstract by February 26th for a chance to speak at this event. The top abstract selected from the speakers will get a travel grant for the Annual Meeting in Kumamoto, Japan in Sept 2025!!!

New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...

Sums it up nicely 🙃 I would just add that thinking is hard and critical thinking harder still....

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses[1][1]–[6][2], but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we a...

1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫

**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**

#mitochondria #immunometabolism #macrophages

📄Read here: www.biorxiv.org/content/10.1...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of L...

Excited to share our new preprint! Exceptional work by @mikelangelipid.bsky.social identifies the first #LipidDroplet lipid quality control pathway! LD-localized FSP1 safeguards neutral lipids from peroxidation and prevents #ferroptosis. 🤩https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1

Looking for exciting opportunities? 🎓 Apply for PhD positions in my lab and others in this fantastic program! 🚀
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs

I’m excited to share new work out of the lab in Nature Metabolism today on the impact of tumor-relevant glucose concentrations on the response to pyrimidine synthesis inhibitors. t.co/9hOGW4x97T. PDF: rdcu.be/d1vkV

Pls RT: Are you studying the multifaceted MAPK pathway? We would love to hear about your exciting research!
Abstract Deadline 👉16.12.2024 for the #virtualmeeting on "Drugging and regulating the #MAPKpathway"
organised with @EACRnews with @Boehringer eacr.org/conference/boe…

I have initiated this #StarterPack with #RedoxBio researchers.

Feel free to suggest other users, or yourself, to be included!

go.bsky.app/UoVRtXp