Lucas Secchim Ribeiro

Finally somebody out there asking the important questions!

www.pnas.org/doi/10.1073/...

Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response - Nature Immunology Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis.

AI-screened inhibitor for GSDMD pores! What a cool finding!!

www.nature.com/articles/s41...

Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in “cell-free” DNA in plasma (cfDNA). An excess of...

Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA | Science www.science.org/doi/10.1126/...

The #IUIS2025 is on!! The @dgfi-org.bsky.social is kicking off the Satellite Symposium in great style at the Austria Center Vienna! #Immunology #Science

Arriving in #Vienna for the #IUIS2025! It is going to be a fantastic conference and if you are around, make sure to reach out, let's talk and build the #Immunology of the future!

Just finished reading the original #Mistborn trilogy and I am amazed with the truly engaging storytelling and character development!

I can really recommend the reading, as I am already looking very much forward to starting the next book from @brandonsanderson.bsky.social!

The five senses of immunity A genealogy of immunity reveals increasingly complex systems for pathogen response, organism homeostasis, and multispecies interaction. New studies show how the five senses can all contribute to behav...

An interesting (and multi-species) short text on the immune senses of organisms! @cellpress.bsky.social

www.cell.com/trends/immun...

It was a pleasure to host the @sawitzkilab.bsky.social for the First Symposium on #SwarmLearning for Precision Medicine! Our team from the @dzne.science is always glad to engage with such outstanding researchers for important collaborations!

Really excited with our plans for the future!

Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults - Nature Communications Many recent proteomics studies use either Olink or SomaScan platforms to quantify proteins in high-throughput, but the consistency between the two is unclear. Here, the authors measure proteins in the...

Great example of how to make good use of #Olink and #SomaScan #proteomics in a population-level study!

www.nature.com/articles/s41...

Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis Caspase-1, -4, -5, and -11 activate Gasdermin D (GSDMD) to form pores in the plasma membrane. In addition to releasing interleukin (IL)-1β and IL-18, GSDMD pores cause a lytic, proinflammatory form of...

Very interesting pre-print from the group of Vishva Dixit in California! The @genentech.bsky.social team found the small-molecule inhibitors of caspase activity can be delivered using GSDMD pores as an entry point!

#Inflammasome #Immunology

www.biorxiv.org/content/10.1...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work!

www.cell.com/immunity/ful...

Immune responses to human pathogens exposed to simulated Mars conditions The identification of health risks associated with long-term crewed missions to Mars is critical for mission planning and crew safety. Human-associated pathogens can be part of the microbiome and are ...

As it turns out, Mars will not be kind to our immune system! Very interesting work from @dlr-spaceagency.bsky.social, @radboudumc.bsky.social and @unibonn.bsky.social!

www.biorxiv.org/content/10.1...

Integration of 168,000 samples reveals global patterns of the human gut microbiome The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...

It has been a while since I worked with microbiome, but it is nice to see such as amazing effort out there! Great work on @cellpress.bsky.social by the group of @blekhman.bsky.social!

www.cell.com/cell/fulltex...

Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation Mitochondria control metabolism, cell death, and innate immunity, yet their reciprocal mechanistic connections are elusive, as is the conserved physiological function of the NLRP3 inflammasome. Saller...

In this very interesting publication on @cp-immunity.bsky.social, Saller and the team of Olaf Gross unveiled the complexity of #NLRP3 activators, highlighting mitochondria’s roles in switching #apoptosis to NLRP3 #inflammasome activation!

www.cell.com/immunity/ful...

Fernanda Torres was a surprise win, taking home her first Golden Globe for best female actor in a drama motion picture for “I’m Still Here.” She told the red carpet ahead of the awards that she was the second Brazilian to be nominated, her mother Fernanda Montenegro being the first. cnn.it/3DIPxFO

Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout)
www.science.org/doi/10.1126/...

Platelet partnerships and lasting memories - Nature Immunology Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine...

With a great comment of @petterbrodin.bsky.social in the same edition! Check it out! #TeamPlatelets

www.nature.com/articles/s41...

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans - Nature Immunology Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccine...

Amazing read to start the year! The team of Bali Pulendran, our #SwarmLearning partner, just published a great article, highlighting the role of #platelet factors and TPO-mediated activation as an important mechanism to enhance the durability of #vaccine responses!

www.nature.com/articles/s41...

Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells.

Not only ASC specks and inflammatory cytokines, but gasdermin pores are found to be shared during pyroptosis! #Inflammasome #Immunology

www.cell.com/cell/fulltex...

The infamous article that stated the fallacious positive effect of hydroxychloroquine and azithromycin for COVID is now retracted, i.e., the results are made up and cannot be reproduced (of course).

Let's hope that good science can prevail - faster - whenever needed the most.