Leon Aksman's Avatar

Leon Aksman

@leonaksman.bsky.social

Asst. Prof of Research at USC's Laboratory of Neuroimaging, working on dementia progression

78 Followers  |  290 Following  |  8 Posts  |  Joined: 19.11.2024  |  2.0173

Latest posts by leonaksman.bsky.social on Bluesky

For this who are unaware, the reason NIH now posts these data habitually on the data book site isโ€ฆ Jeremy Berg. He pioneered this openness as NIGMS Director.

26.09.2025 15:14 โ€” ๐Ÿ‘ 75    ๐Ÿ” 17    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
Post image

๐Ÿง New paper alert!
We define PI-2620 tau PET cutpoints in a diverse cohort โ€” summary of ๐Ÿ—๏ธ findings below โฌ‡๏ธ
675 adults:
โ€ข AB+ cognitively impaired (CI)
โ€ข ABโ€“ cognitively unimpaired (CU)
โ€ข 28% Hispanic, 31% NH Black, 41% NH White
๐Ÿ”— Read it here:
(bit.ly/44RLVwe)
@victoriatennant.bsky.social

08.07.2025 19:00 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Did you control for how many users you have on both platforms?

09.06.2025 19:29 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐ŸŽ‰Congrats to PhD student, Amaryllis Tsiknia, who led our new paper bit.ly/3ZndVVh studying how diabetes relates to cortical thickness in Hispanic & non-Hispanic Black & White older adults!

Read more here: bit.ly/3GS0Ddj
More on our findings soon...

15.05.2025 17:27 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Blood-based biomarkers of Alzheimerโ€™s disease and incident dementia in the community - Nature Medicine In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimerโ€™s disease were able to predict dementia up to 16 years before disease onset.

Blood-based biomarkers of Alzheimerโ€™s disease and incident dementia in the community

Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia

www.nature.com/articles/s41...

31.03.2025 14:33 โ€” ๐Ÿ‘ 21    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Cancelled NIH grant information submission form Please use this form to submit information identifying specific NIH grants that have been cancelled for any reason after January 20, 2025. Data from this form will be used to update the Rescinded NIH...

The crush of new grant cancellations hasn't let up.

If your grant was terminated (or your app was pulled) please use this Google Form๐Ÿ‘‡ to submit details for tracking purposes.

Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.

21.03.2025 03:32 โ€” ๐Ÿ‘ 439    ๐Ÿ” 496    ๐Ÿ’ฌ 10    ๐Ÿ“Œ 31
Preview
Opinion | We Were Badly Misled About Covid Five years after the start of Covid, we still donโ€™t know the truth.

www.nytimes.com/2025/03/16/o...

17.03.2025 16:03 โ€” ๐Ÿ‘ 12    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Preview
a man in a red suit and tie is holding a piece of paper that says breaking news on it ALT: a man in a red suit and tie is holding a piece of paper that says breaking news on it

Some good-ish news from NIH

โ€œFederal Register notices for study sections run by CSR (but not those by ICs) will start being permitted againโ€

As far as I know, the timing for this is not clear, but I will be checking the Federal Register.

24.02.2025 16:38 โ€” ๐Ÿ‘ 393    ๐Ÿ” 152    ๐Ÿ’ฌ 17    ๐Ÿ“Œ 16
Review Dates

41/47 (87%) of NIH study sections are cancelled this week

Frustrating to see all this good research stalled (& not funded)

You can search for study sections that โ€˜did not meet as scheduledโ€™ here with ones with * โคต๏ธ
www.csr.nih.gov/RevPanelsAnd...

20.02.2025 02:03 โ€” ๐Ÿ‘ 145    ๐Ÿ” 123    ๐Ÿ’ฌ 10    ๐Ÿ“Œ 16

What can we do to get Science Magazine to drop their paywall for a while, while all this critically important news is being reported on? The public needs to know. Great journalists are covering these stories. where will they and the magazine be without the scientists and the research?

16.02.2025 10:29 โ€” ๐Ÿ‘ 79    ๐Ÿ” 10    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 1

These cases are just incredible

13.02.2025 19:39 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

I just wanted to share that I received the NoA for the second year of my R21 today. I know people are feeling anxious and I just hope some good news from the NIH can help. Hang in there - we'll get through this! โค๏ธ

27.01.2025 20:13 โ€” ๐Ÿ‘ 116    ๐Ÿ” 6    ๐Ÿ’ฌ 9    ๐Ÿ“Œ 2
Preview
Trump hits NIH with โ€˜devastatingโ€™ freezes on meetings, travel, communications, and hiring Researchers facing

โ€œThe impact of the collective executive orders and directives appears devastating.โ€ scim.ag/40ureTO

22.01.2025 23:28 โ€” ๐Ÿ‘ 1025    ๐Ÿ” 732    ๐Ÿ’ฌ 49    ๐Ÿ“Œ 128
Preview
The Scientist vs. the Machine What happened when AI took over these researchersโ€™ jobs?

I got a lot of insights into how AI might work in scientific research from this convo:
www.theatlantic.com/podcasts/arc...

14.01.2025 22:08 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Obstructive sleep apnea, cognitive impairment, and dementia: is sleep microstructure an important feature? Obstructive sleep apnea (OSA) and dementia are both prevalent conditions in the aging population [1, 2]. Scientific evidence indicates that OSA is associat

The importance of sleep microarchitecture- in addition to total sleep time - for cognition

academic.oup.com/sleep/articl...

06.01.2025 16:29 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Welcome!

19.12.2024 16:51 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Survival bias? Those who can no longer navigate drop out of these professions as they get older?

17.12.2024 17:55 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
This is figure 1, which is a graphical abstract of this research.

This is figure 1, which is a graphical abstract of this research.

A Nature Aging paper identifies 13 proteins linked to brain aging. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old, and suggest that these ages may be important for potential interventions in the brain aging process. https://go.nature.com/3ZvGLSy ๐Ÿงช

10.12.2024 15:21 โ€” ๐Ÿ‘ 73    ๐Ÿ” 15    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

Agree that the current system sucks, but how would this work in practice?
1) Paying a flat rate per paper may incentivize rejections.
2) Paying for each step in the review process may incentivize more revisions.

04.12.2024 19:39 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Tau filaments are tethered within brain extracellular vesicles in Alzheimerโ€™s disease - Nature Neuroscience Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimerโ€™s disease, shining l...

www.nature.com/articles/s41...

21.11.2024 20:04 โ€” ๐Ÿ‘ 83    ๐Ÿ” 17    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 2

Hi, please add me as well. Thank you!

21.11.2024 17:20 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Hi, please add me

21.11.2024 17:12 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@leonaksman is following 20 prominent accounts