Leon Aksman

🚨 NEW study out in Alzheimer's & Dementia from our very own @meredithbraskie.bsky.social & Amaryllis Tsiknia 🧠

Learn how subtle changes in how blood flows through the brain and how brain tissue uses oxygen may be closely linked to Alzheimer’s disease risk

Press release: bit.ly/46UqkUu

Research Assistant: Early Detection of Neurodegenerative Diseases UCL London seeks a Research Assistant to support data driven modelling of neurodegenerative disease within the POND group, working with clinical cohorts.

UCL London seeks a Research Assistant to support data driven modelling of neurodegenerative disease within the POND group, working with clinical cohorts.

www.dementiaresearcher.nihr.ac.uk/job/research...

For this who are unaware, the reason NIH now posts these data habitually on the data book site is… Jeremy Berg. He pioneered this openness as NIGMS Director.

🧠New paper alert!
We define PI-2620 tau PET cutpoints in a diverse cohort — summary of 🗝️ findings below ⬇️
675 adults:
• AB+ cognitively impaired (CI)
• AB– cognitively unimpaired (CU)
• 28% Hispanic, 31% NH Black, 41% NH White
🔗 Read it here:
(bit.ly/44RLVwe)
@victoriatennant.bsky.social

Did you control for how many users you have on both platforms?

🎉Congrats to PhD student, Amaryllis Tsiknia, who led our new paper bit.ly/3ZndVVh studying how diabetes relates to cortical thickness in Hispanic & non-Hispanic Black & White older adults!

Read more here: bit.ly/3GS0Ddj
More on our findings soon...

Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community - Nature Medicine In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimer’s disease were able to predict dementia up to 16 years before disease onset.

Blood-based biomarkers of Alzheimer’s disease and incident dementia in the community

Increased p-tau181, p-tau217, NfL, and GFAP demonstrated strong predictive performance (area under the curve ranging from 70.9% to 82.6%) for 10-year all-cause and AD dementia

www.nature.com/articles/s41...

Cancelled NIH grant information submission form Please use this form to submit information identifying specific NIH grants that have been cancelled for any reason after January 20, 2025. Data from this form will be used to update the Rescinded NIH...

The crush of new grant cancellations hasn't let up.

If your grant was terminated (or your app was pulled) please use this Google Form👇 to submit details for tracking purposes.

Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.

Opinion | We Were Badly Misled About Covid Five years after the start of Covid, we still don’t know the truth.

www.nytimes.com/2025/03/16/o...

a man in a red suit and tie is holding a piece of paper that says breaking news on it ALT: a man in a red suit and tie is holding a piece of paper that says breaking news on it

Some good-ish news from NIH

“Federal Register notices for study sections run by CSR (but not those by ICs) will start being permitted again”

As far as I know, the timing for this is not clear, but I will be checking the Federal Register.

41/47 (87%) of NIH study sections are cancelled this week

Frustrating to see all this good research stalled (& not funded)

You can search for study sections that ‘did not meet as scheduled’ here with ones with * ⤵️
www.csr.nih.gov/RevPanelsAnd...

What can we do to get Science Magazine to drop their paywall for a while, while all this critically important news is being reported on? The public needs to know. Great journalists are covering these stories. where will they and the magazine be without the scientists and the research?

These cases are just incredible

I just wanted to share that I received the NoA for the second year of my R21 today. I know people are feeling anxious and I just hope some good news from the NIH can help. Hang in there - we'll get through this! ❤️

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO

The Scientist vs. the Machine What happened when AI took over these researchers’ jobs?

I got a lot of insights into how AI might work in scientific research from this convo:
www.theatlantic.com/podcasts/arc...

Obstructive sleep apnea, cognitive impairment, and dementia: is sleep microstructure an important feature? Obstructive sleep apnea (OSA) and dementia are both prevalent conditions in the aging population [1, 2]. Scientific evidence indicates that OSA is associat

The importance of sleep microarchitecture- in addition to total sleep time - for cognition

academic.oup.com/sleep/articl...

Welcome!

Survival bias? Those who can no longer navigate drop out of these professions as they get older?

This is figure 1, which is a graphical abstract of this research.

A Nature Aging paper identifies 13 proteins linked to brain aging. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old, and suggest that these ages may be important for potential interventions in the brain aging process. https://go.nature.com/3ZvGLSy 🧪

Agree that the current system sucks, but how would this work in practice?
1) Paying a flat rate per paper may incentivize rejections.
2) Paying for each step in the review process may incentivize more revisions.

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature Neuroscience Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l...

www.nature.com/articles/s41...

Hi, please add me as well. Thank you!

Hi, please add me