Randy Read 🇨🇦🇬🇧

At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.

Finally comms from UKRI - on a Sunday evening. No mention of the hundreds of ECRs who will see their careers ended by these decisions and notably no explanation for MRC retrospectively applying cuts and wasting all the work that went into writing, reviewing and scoring applications - £millions

Missed it, thanks for pointing it out!

My hero!!! An amazing scientist and a wonderful person!

Has the MRC research funding ‘pause’ been covered by any major news network?

It feels like it should be a major news story

We have a fantastic opportunity for a PhD studentship in collaboration with @jesuscollegecam.bsky.social and Cambridge Children’s Research Institute, part of the new Cambridge Children’s Hospital. Closing date 20th Feb; all the details here: www.cimr.cam.ac.uk/postgraduate...

She continues to be a lively presence at structural biology meetings. And for my money has the deepest, most intuitive understanding of protein geometry. A treasure.

As someone who works directly with her in Phenix, I can tell you she is still one of the most focused and dedicated people I know!

By the way, this is by the @alisiafadini.bsky.social behind ROCKET!

GitHub - rs-station/meteor: bringing you the best difference maps bringing you the best difference maps. Contribute to rs-station/meteor development by creating an account on GitHub.

New Title Alert: meteor- a tool for computing crystallographic difference maps that specializes in robust identification of weak signals from minor populations such as bound ligands or time-resolved experimental changes.

Learn more here: buff.ly/bgJYF9N

#SBGrid #SBGridSoftware #StructuralBiology

Mapping proteins, one side chain at a time Roland Dunbrack Jr. will receive the ASBMB DeLano Award for Computational Biosciences at the ASBMB Annual Meeting, March 7–10, just outside of Washington, D.C.

This appeared today: www.asbmb.org/asbmb-today/...

Now available: the Proceedings of the 2024 @ccpem.bsky.social em Spring Symposium, including a review of the first ten years of the Symposium: journals.iucr.org/special_issues/2025/CCPEM2024/

View all of the Proceedings at journals.iucr.org/d/services/ccpem

Hope to see you there!

Logos for IUCr2026 and Phenix

#IUCr2026 Pre-Congress Workshop: Structure Solution with Phenix
Offers lectures and tutorials on using Phenix for automated macromolecular structure determination and validation from xtal and cryoEM data, integrating predicted models like AlphaFold
event.fourwaves.com/...

There are a lot of ways to say in words how confident you are about something happening, so it’s good to see how consistent you are with yourself and others! (Turns out I’m not very consistent in how I rank near-synonyms.)

Our January issue is out: journals.iucr.org/d/issues/202...

The cover highlights a data survey of the PDB and CSD for macromolecular and ligand structures that have been determined at elevated temperatures. Read more at doi.org/10.1107/S205...

Check our new preprint smoothing rugged Cryo-EM landscapes: shorturl.at/gYs9U

We tackle practical hurdles of Optimal Transport (OT) loss—differentiability, cost & noise sensitivity—make it a feasible inference workhorse.
W/ G. Woollard, D. Herreros, @pilarcossio.bsky.social, K. Dao Duc 🧵👇 (1/9)

This is a classic of the genre!

RE: https://fediscience.org/@Guillawme/111534984107819771

Something really cool happened to me this year!

@HRBridges re-processed a #cryoEM dataset from some previous work of mine and colleagues (publicly available as EMPIAR-10739; see quoted post below for a summary of this work). She […]

I got one even though I don’t have a current NIH grant. I’ve certainly been asked to update things before, though maybe not with this wording.

PDBe: enhanced structural data exploration to facilitate discovery Abstract. Protein Data Bank in Europe (PDBe) is a founding member of the worldwide Protein Data Bank (wwPDB), delivering open access to experimentally dete

From Sameer Velankar & colleagues in @narjournal.bsky.social #NARDatabaseIssue | PDBe: enhanced structural data exploration to facilitate discovery | #Bioinformatics #Database #OpenScience #Proteomics #PDB 🧬 🖥️🧪🔓
⬇️
academic.oup.com/nar/advance-...

Wow, that’s exciting! Looking forward to seeing what you get up to!

Top UK scientist says research visa restrictions endanger economy Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.

BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...

IUCr 2026 Grants

Apply for #IUCr2026 travel grants
Funds are available to support students, early-career researchers, and participants from under-resourced institutions and/or developing countries.
Details at event.fourwaves.com/...

🚨 Apply now for the 2026 Erice School!
From Structural Biology to Structural Cell Biology with the aid of Machine Learning
📅 May 31–June 9, 2026
⏳ Deadline: Dec 7, 2025
🌐 Info: crystalerice.org/2026

It’s great to see people thinking about tracking errors in Fourier terms! EM_placement tries to infer effects of orientation bias from half maps, but it would be far better to do this directly in the reconstruction process. No surprise it’s people like ZO and Dominika doing this work!

Ten years of the CCP-EM Spring Symposium This article reviews the growth over the last ten years of the CCP-EM Spring Symposium. The conference is now established as a popular meeting for practitioners of life-science cryoEM and highlights new methods and exemplar applications.

Giles and Burnley: Ten years of the CCP-EM Spring Symposium #Cryoem #ElectronCryoMicroscopy #CCPEM ... #IUCr https://journals.iucr.org/paper?S2059798325010496

I really like the new summary representation Airlie has come up with for the self rotation function!

Frontier structural biology chases low occupancies: weak binders in drug discovery & fleeting intermediates in time-resolved studies. When squeezing SNR, confirmation bias looms – you can see what you hope to see in the noise! Enter METEOR ☄️, our denoising+phasing framework! 1/8

Chris is a brilliant structural biologist and mentor. Would highly recommend applying!