Courtney Malo

Join #ScienceTranslationalMedicine on June 13 for a virtual award ceremony and lecture honoring the 2025 Wachtel Cancer Research Award winner, Dr. Karin Pelka!

Register here: american-association-for-the-advancement-of-science.ticketbud.com/aaas-martin-...

@science.org

Thoroughly impressed, @eberllab.bsky.social!

It’s #norovirus week in #ScienceTranslationalMedicine! Two papers show that we can vaccinate against norovirus in older adults and that vaccines have the potential to be broadly protective. Good news for anyone afraid of norovirus (me!).

www.science.org/toc/stm/curr...

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...

We are thrilled to share our new manuscript @science.org , in which we uncovers a critical role for macrophage peroxisomes in lung repair after viral infection. Could targeting peroxisomes be the key to mitigating long COVID?! www.science.org/doi/10.1126/...

Plan to join our upcoming #ScienceTranslationalMedicine webinar on #LongCOVID, taking place on 21 February at 1:30 pm ET! scim.ag/3EF8UQv @science.org

This week's issue of #ScienceTranslationalMedicine moo-ves 🐄 us towards pandemic preparedness by reporting an mRNA vaccine that protects ferrets against #avianflu #H5N1. @science.org

www.science.org/toc/stm/16/778

Good news on a H5N1 vaccine efficacy in a preclinical model in case it is needed
science.org/doi/10.1126/...

Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

"Many HIV/AIDS researchers are now hopeful that the drug, lenacapavir, will powerfully drive down global infection rates when used as pre-exposure prophylaxis (PrEP)."

Lenacapavir: @science.org 's Breakthrough of the Year!

Always a tough call at @science.org what to name the Breakthrough of the Year. But as someone interested in infectious diseases and living with HIV, this is truly a remarkable breakthrough.
We now have yet another amazing tool to stop new HIV infections. We need to use them all!
🧪 #IDsky #HIVsky

RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.

Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation

One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice.

www.science.org/doi/10.1126/...

Single-cell profiling of acral melanoma infiltrating lymphocytes reveals a suppressive tumor microenvironment Single-cell immune profiling of tumor-infiltrating T lymphocytes in acral melanoma revealed increased NKG2A expression in antitumor TILs.

Last but not least, Minowa and colleagues show that #acralmelanoma is immunologically distinct from it's cutaneous #melanoma cousin, suggesting that a different therapeutic approach is needed for these patients. www.science.org/doi/10.1126/...

Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation Diverse natural killer T cells regulate innate immunity to improve neurological outcomes and survival after cardiac arrest.

Tamura and team show that a population of NKT cells can promote better neurological outcomes after #cardiacarrest. @edykimlab.bsky.social www.science.org/doi/10.1126/...

RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.

Santamaria et al. show that RANKL treatment can restore #thymus function in aged mice, improving #antitumor and #vaccine responses. Could RANKL be the thymic fountain of youth? www.science.org/doi/10.1126/...

It's an #immunology triple feature this week in #ScienceTranslationalMedicine! @science.org

Engineering CAR-T therapies for autoimmune disease and beyond Emerging CAR-T technologies offer transformative potential to address the needs of patients with autoimmunity or other diseases beyond cancer.

Scientists have made major strides in engineering CAR-T cell therapies to treat autoimmune disorders such as lupus, according to a new #ScienceTranslationalMedicine Review that discusses the latest breakthroughs and clinical trials in the field. scim.ag/4f0RmL1

Well now it feels official!

I can't think of a better first post than to highlight STM's recent special issue on #longcovid. www.science.org/toc/stm/16/773