John

Tariffs are consumer-tax, so no point in doubling, matching is more than enough. What should've become abundantly clear is that the EU needs to own its own tech industry. The "mag 7" domination of the tech landscape hurts Europe the most.

This is an excellent meeting for anyone interested in immunology, virology, host-pathogen interactions, immune signalling. Abstract submission deadline is 1 Feb.

Online today! 👉 Dynamics of checkpoint receptors in #γδTcell subsets are associated with clinical response during anti-PD-1 #immunotherapies

By E. Catafal-Tardos, @vasgdtcells.bsky.social & colleagues at Technical University of Denmark

🗞️ doi.org/10.1038/s443...

Split-site ubiquitination gives ZNFX1 new power in RNA defense Recent work by Grabarczyk et al. uncovers the molecular mechanism by which ZNFX1, an interferon-stimulated gene, employs a novel split-site E3 ligase domain structure to ubiquitinate both protein lysi...

Split-site ubiquitination gives ZNFX1 new power in RNA defense @cellcellpress.bsky.social
www.cell.com/molecular-ce...
www.sciencedirect.com/science/arti...

Dysregulated T cells and progenitors with lymphoma driver mutations are enriched in duodenal biopsies from patients with refractory celiac disease
www.science.org/doi/10.1126/...

Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...

Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice

Nasal vaccines as booster, after i.m vaccination, to improve local IgA production. No additional adjuvant needed (mice and hamsters). Nice paper!

www.nature.com/artic...
1/6

Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα, say Artur Stoljar, Maksym Zarodniuk, Pärt Peterson and colleagues @unitartu: rupress.org/jem/article/...

#Autoimmunity #Tolerance

This is where engagement becomes essential. At the very least, communicate back that you actually fully appreciate the work, the literature, or the reviewer's missteps - they aren't infallible either you know !

But "they are smart people, i'm sure they understood". Well, i'm sure most of us are smart people, but i quite often have a hard time appreciating some papers that are outside my immediate -Tcell- comfort zone.
I don't imagine i'm the smartest cat on the block, so it might be a "me" problem.

How is one supposed to interpret a "copy and paste" editorial letter ? Did they even read anything the authors wrote ? Did they understand the work discussed ?

It's incredibly disturbing when journal editors act infallible.

A modicum of engagement, or any sort of scientific discourse, would certainly go along way.

These are simply the moments that make me hate, absolutely hate, doing science - and i have been in it long eough to know better !

'We found that citrullinated MBP160–175 (MBP160–175(cit)), when co-immunized with MOG35–55, indeed no longer suppressed EAE, implying a specific immunomodulatory function for naked MBP160–175 peptides in regulating neuroinflammation'
#Immunology #Immunosky
www.nature.com/articles/s41...