John

Split-site ubiquitination gives ZNFX1 new power in RNA defense Recent work by Grabarczyk et al. uncovers the molecular mechanism by which ZNFX1, an interferon-stimulated gene, employs a novel split-site E3 ligase domain structure to ubiquitinate both protein lysi...

Split-site ubiquitination gives ZNFX1 new power in RNA defense @cellcellpress.bsky.social
www.cell.com/molecular-ce...
www.sciencedirect.com/science/arti...

Dysregulated T cells and progenitors with lymphoma driver mutations are enriched in duodenal biopsies from patients with refractory celiac disease
www.science.org/doi/10.1126/...

Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...

Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice

Nasal vaccines as booster, after i.m vaccination, to improve local IgA production. No additional adjuvant needed (mice and hamsters). Nice paper!

www.nature.com/artic...
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Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα, say Artur Stoljar, Maksym Zarodniuk, Pärt Peterson and colleagues @unitartu: rupress.org/jem/article/...

#Autoimmunity #Tolerance

This is where engagement becomes essential. At the very least, communicate back that you actually fully appreciate the work, the literature, or the reviewer's missteps - they aren't infallible either you know !

But "they are smart people, i'm sure they understood". Well, i'm sure most of us are smart people, but i quite often have a hard time appreciating some papers that are outside my immediate -Tcell- comfort zone.
I don't imagine i'm the smartest cat on the block, so it might be a "me" problem.

How is one supposed to interpret a "copy and paste" editorial letter ? Did they even read anything the authors wrote ? Did they understand the work discussed ?

It's incredibly disturbing when journal editors act infallible.

A modicum of engagement, or any sort of scientific discourse, would certainly go along way.

These are simply the moments that make me hate, absolutely hate, doing science - and i have been in it long eough to know better !

'We found that citrullinated MBP160–175 (MBP160–175(cit)), when co-immunized with MOG35–55, indeed no longer suppressed EAE, implying a specific immunomodulatory function for naked MBP160–175 peptides in regulating neuroinflammation'
#Immunology #Immunosky
www.nature.com/articles/s41...