To showcase science you’re interested in seeing at ASHG26 in Montreal, submit a proposal for a Featured Symposium. Deadline is Jan 20th. Topics of interest include ‘evolutionary approaches to biological and clinical insights from phylogeny or recent human/primate lineages'.
21.11.2025 05:23 — 👍 2 🔁 0 💬 0 📌 0
Thank you to the reviewers for helping us focus and strengthen the manuscript, and the editors for a smooth publication process. [3/3]
29.10.2025 05:15 — 👍 0 🔁 0 💬 0 📌 0
We found large-scale rewiring of the chromatin landscape across related drugs that coincide with TOP2B binding, neighboring gene expression changes and loci associated with atrial fibrillation. [2/3]
29.10.2025 05:15 — 👍 1 🔁 0 💬 1 📌 0
Happy to be at ASHG!
2 students in the lab will present posters on gene regulatory evolution in primates on Thurs:
Emma focuses on responses to stimuli: 9109T
John focuses on transposable elements: 6036T
Please stop by if interested #ASHG25
16.10.2025 03:49 — 👍 6 🔁 1 💬 0 📌 0
We believe this work provides insight into the role of topoisomerase II beta in gene regulation, and cancer patient risk for cardiovascular disease. [4/4]
24.07.2025 23:52 — 👍 1 🔁 0 💬 0 📌 0
We compared the effects of CX and DOX in human cardiomyocytes. CX is 20-fold less toxic than DOX and induces an order of magnitude fewer changes in gene expression despite a shared target. However, CX-induced transcriptional changes are shared with DOX. [3/4]
24.07.2025 23:52 — 👍 1 🔁 0 💬 1 📌 0
DOX is an effective anti-cancer drug. However, it inhibits the DNA topology regulator topoisomerase II beta in the heart leading to increased risk for cardiovascular disease. CX-5461 is a promising novel anti-cancer compound that was recently shown to target the same protein. [2/4]
24.07.2025 23:52 — 👍 0 🔁 0 💬 1 📌 0
Project led by Sayan investigating the effects of CX-5461, an anti-cancer drug currently in clinical trials, on cardiomyocytes: ‘Topoisomerase II inhibitors CX-5461 and Doxorubicin differ in their cardiotoxicity profiles.’ [1/4] www.biorxiv.org/content/10.1...
24.07.2025 23:52 — 👍 3 🔁 0 💬 1 📌 0
Happy to share our work led by Renee: ‘Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci.’
www.biorxiv.org/content/10.1...
19.06.2025 00:20 — 👍 7 🔁 2 💬 0 📌 0
Congrats Anat, Nehal and Guy!
17.06.2025 04:39 — 👍 1 🔁 0 💬 1 📌 0
Congrats Ben!
03.06.2025 03:49 — 👍 1 🔁 0 💬 0 📌 0
Happy to share the published version of Omar & Sayan’s paper. We generated a DNA-damage-associated cardiomyocyte protein co-expression network to gain insights into tolerance to genetic variation and disease. www.sciencedirect.com/science/arti...
09.05.2025 23:38 — 👍 5 🔁 3 💬 0 📌 0
Congrats Tauras!
06.05.2025 03:15 — 👍 1 🔁 0 💬 0 📌 0
Come join us at #ASHG25 in Boston Oct 14-18! Abstract submission site (ashg.org/submit) is now live. Abstracts due June 9th.
02.05.2025 01:02 — 👍 5 🔁 0 💬 0 📌 0
Official account for The University of Texas Medical Branch
Bioinformatics Scientist, NIH/NIAID, Vaccine Research Center
Associate Professor at USC, Center for Genetic Epidemiology. Population genetics, statistical genetics & human genetics/genetic epidemiology. A city, mountain, dance, candy & a drosophila gene. UCLA->Harvard->UCLA->USC.
http://chianglab.usc.edu
Assistant prof at UCLA using the Bayes for the genomes https://pimentellab.com
The Gregory lab @DukeU studies disease mechanism using scRNAseq & spatial molecular technologies. Focus on brain tumors, Alzheimer's and MS 🧠 Home to the Molecular Genomics Core (MGC) - https://dmpi.duke.edu/cores/molecular-genomics-core-mgc
Assistant Professor
UAB Biochemistry & Molecular Genetics
Functional Genomics | Neuroepigeneticist, chromatin enthusiast | #epigenetics #singlecell Views/posts my own. She/her
SMBE fosters communication among molecular evolutionists and advances the field.
🔗 smbe.org
💬 smbe2026.org • biosig.lab.uq.edu.au/strphy26
👥 @smbe-idea.bsky.social
📙 @molbioevol.bsky.social • @genomebiolevol.bsky.social
Principal Investigator at Boston Children's Hospital | Statistical Genetics
Ph.D. Candidate and MPH student at University of Texas Medical Branch in Galveston, TX. Cancer genome organization researcher hoping to change outcomes for those left under-represented.
🧬Founded in 1948, the American Society of Human Genetics (ASHG) is the primary professional membership organization for #humangenetics specialists worldwide.
www.ashg.org
Principal Investigator at the Stowers Institute for Medical Research
Professor of Developmental Genomics and Gene Regulation, University of Oxford
Senior Research Fellow at Jesus College
Physician-scientist @ the intersection of genomics, hematology/oncology, & patient care. Runner. Tweets are my own - no COI. Scholar: https://shorturl.at/r7pPC Lab: thedrazergroup.org
Postdoc @tgenresearch.bsky.social in the Banovich lab
Structural Biology lab, Biochemistry, Indiana University
Viral replication and infection machinery, RNA structure, X-ray crystallography, cryo-electron microscopy
Research Assistant Professor within the Division of Bioinnovation and Genome Sciences at the Translational Genomics Research Institute, part of City of Hope. heinin.github.io
Group Leader @mrc_hgu investigating gene regulation in development & human disease
henfluencer - geriatric millennial - #stopasianhate - don’t call me Clem - emotional eater™️- he/him- @chowlab
https://linktr.ee/clementchow
