Harold Pimentel

The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)

Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation

doi.org/10.1101/2025...

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yikes... sorry...

my only advice is to proactively carry a 5lb bag of rice with your laptop

The first (of hopefully many) reports to come from our collaboration with @hjp.bsky.social

We present a new type of cell fitness assay that allows you to both quantify and explain differences across human donors in cell proliferation and sensitivity to environmental toxicants.

Thanks!

Thank you!

Huge congrats to my student Chloe who led the computational side, and Mike's student Tim who led the experimental side. Both worked diligently on the analysis. And of course, many congrats to my collaborator and friend @mfwells.bsky.social and his lab who did all the experimental work

Stay tuned -- much more in queue

3. we apply these experimental and computational advances along with 'GWAS in a dish' approaches to find genetic variants associated with NPC proliferation. further, we find genetic variants associated with response to lead in NPCs

2. develop computational models that model the nuance in cell villages, including the compositional nature, small sample sizes, and structure of the variance

Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we:

1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs

bsky.app/profile/bior...

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Color me surprised that the same people who don't believe solid epi over decades (like those guiding nutritional guidelines) believe this. Unreal.

Harvard Dean Was Paid $150,000 as an Expert Witness in Tylenol Lawsuits

Radical transparency

🎁
www.nytimes.com/2025/09/23/h...

Super excited to have this out. Thanks very much to the reviewers who helped improve this manuscript. Congrats to @jingyour.bsky.social!

bsky.app/profile/bioi...

Pretty sure that’s the point bsky.app/profile/josh...

5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 IN THE UNITED STATES DISTRICT COURT FOR THE NORTHERN DISTRICT OF CALIFORNIA GAVIN NEWSOM, et al., Plaintiffs, Case No. 25-cv-04870-CRB OPINION GRANTING INJUNCTIVE RELIEF V. DONALD J. TRUMP, et al., Defendants. Congress spoke clearly in 1878 when it passed the Posse Comitatus Act, prohibiting the use of the U.S. military to execute domestic law. Nearly 140 years later, Defendants President Trump, Secretary of Defense Hegseth, and the Department of Defense deployed the National Guard and Marines to Los Angeles, ostensibly to quell a rebellion and ensure that federal immigration law was enforced. There were indeed protests in Los Angeles, and some individuals engaged in violence. Yet there was no rebellion, nor was civilian law enforcement unable to respond to the protests and enforce the law. Nevertheless, at Defendants' orders and contrary to Congress's explicit instruction, federal troops executed the laws. The evidence at trial established that Defendants systematically used armed soldiers (whose identity was often obscured by protective armor) and military vehicles to set up protective perimeters and traffic blockades, engage in crowd control, and otherwise demonstrate a military presence in and around Los Angeles. In short, Defendants violated the Posse Comitatus Act.

BREAKING: Trump, Hegseth violated the Posse Comitatus Act with their troop deployment to Los Angeles, Judge Charles Breyer rules after trial. storage.courtlistener.com/recap/gov.us...

THE HILL HEALTH CARE RFK Jr. says agency will reveal causes of autism in September BY JOSEPH CHOI - 08/26/25 4:01 PM ET

You’re not dropping a single, asshole.

If you’re actually knew anything, it would be criminal not to reveal it now. But of course, this is a bullshit publicity stunt.

it's a flyer: 'gerrymandering is wrong - no matter who does it', framed as a 'power grab'.

i imagine this implicitly anti-newsom flyer is showing up on doorsteps across california.

'visit protectfairelections.org to learn more,' it says. 'paid for by Right Path Coalition'.

which is . . . led by the chairperson of the california republican party

JXTX + CSHL 2025 Genome Informatics Scholarship JXTX + CSHL 2025 Genome Informatics Scholarships

From @jxtxfoundation.bsky.social | JXTX + CSHL 2025 Genome Informatics Scholarships | Up to $750 for domestic or $1,250 for international travel | Application deadline is September 15, 2025 | #OpenScience 🧬 🖥️ 🧪
⬇️
jxtxfoundation.org/news/2025-6-...

Science will always be political when it tries to help people who the political establishment doesn't center as the default American.

Health disparities? Climate change? Public health?

Have always been political, will always be political.

US Supreme Court allows NIH to cut $2 billion in research grants The decision will hinder lawsuits against grant terminations, legal specialists say.

Yesterday the Supreme Court issued a convoluted, 36-page emergency order about NIH grant terminations. Two main takeaways:
-$2 billion (not the government # of $780 million) in NIH grants will likely be re-terminated
-future legal challenges will be much harder

w/ @maxkozlov.bsky.social:

Well deserved. Congrats, Arjun!

Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level - British Journal of Cancer British Journal of Cancer - Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level

Very proud of @ytchang11.bsky.social for her first publication from her doctoral research! She conducted very meticulous genomic analyses that uncovered novel isoform-specific mechanistic hypotheses underlying genetic loci associated with multiple cancers.

www.nature.com/articles/s41...

Very excited to have this out! Here, we take inspiration from model selection MR to decouple direct and indirect effects in DMS experiments. Check out Jingyou's explainer and paper below:

bsky.app/profile/jing...

Hot dog meme from Tim Robinson’s I Think You Should Leave, but featuring JB in a hearing room

Text from an FAQ in Okbay et al 20222: https://www.nature.com/articles/s41588-022-01016-z a similar same statement is made in an FAQ in 2025: https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1.supplementary-material Text reads: "The results of SSGAC studies have sometimes been used by online platforms, including some companies, to predict individual outcomes. We recognize that returning individual genomic “results” can be a fun way to engage people in research and other projects and to feed or stoke their interest in genomics. But it is important that participants/users understand that these individual results are not meaningful predictions and should be regarded essentially as entertainment. Failure to make this point clear risks sowing confusion and undermining trust in genetics research"

It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ

Trump freezes $200 million in UCLA science and medical research funding, citing antisemitism The Trump administration has frozen roughly $200 million in National Science Foundation, National Institutes of Health and other federal agency-funded research at UCLA, citing allegations the school d...

Suspension of all grants to UCLA www.latimes.com/california/s...

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