Franziska Auer

Part 2 of the joint EHA/ISEH session at #ISEH2025 Kumamoto: Zuzana Tothova on therapeutic targeting of cohesin-mutant myeloid malignancies @isehsociety.bsky.social

Methods and applications of in vivo CRISPR screening Nature Reviews Genetics, Published online: 29 July 2025; doi:10.1038/s41576-025-00873-8In vivo CRISPR screens generate high-throughput, unbiased genotype–phenotypes maps for complex biological processes that cannot be studied in vitro. This Review outlines key criteria for understanding, designing and implementing such screens and discusses their potential impact on basic and translational research.

New online! Methods and applications of in vivo CRISPR screening

Integrated in vivo combinatorial functional genomics and spatial transcriptomics of tumours to decode genotype-to-phenotype relationships - Nature Biomedical Engineering A method integrates perturbation mapping with 10X Visium spatial transcriptomics to map tumour genetic complexity and heterogeneity.

This is a great set of methods for studying combinatorial effects of cancer mutations on spatial phenotypes.

Clever experimental design by @breinigmarco.bsky.social hijacking Visium and elegant analysis by @lomakinai.bsky.social and @elihei.bsky.social

www.nature.com/articles/s41...

Panels A–C: Features of measles including Koplik spots on the buccal mucosa; rash on the trunk, spreading to the face, head, arms, and legs; and conjunctivitis. Panel D: A timeline of the pathogenesis of measles.

In a new article on measles, the authors review the epidemiology, clinical presentation, and associated illnesses as well as treatment and prevention strategies. Read the full article: nej.md/4lmC1Ir

#MedSky @lshtm.bsky.social

Make sure not to miss the last #YERM Session on „New frontiers in preclinical development of cellular therapies and other immunotherapies“ at 15.45 pm. #EHA2025 #Hematology

Interested in actively participating in YERM next year? Check out the link below!

🚨Today! @ 15:45, MiCo room CORAL 6 
We warmly invite you to the HemaSphere Scientific Session where we will dive into 3 of our exciting + cutting-edge biology publications. Hope to see you there!
🕰️: 15:45 - 16:45
📍: Room CORAL 6, #EHA2025
🎤: https://bit.ly/4koLwXk

A big thank you to all the speakers in session 2 of #YERM ! See you this afternoon for session 3 on cellular plasticity #youngEHA #EHA2025

Don’t miss the second YERM Session on „New insights into clonal hematopoiesis“ at 10 o‘clock in Brown Hall 2!
#EHA2025 #YoungEHA #Hematology

If you're attending #EHA2025, make sure you don't miss the #YoungEHA Research Meeting (YERM) today. It starts off with an exciting session on "Erythropoiesis: From biology to pathology" at 8 o'clock in the Brown Hall 2!

🎉 Congratulations to Jon Salmanton-García on his appointment to the Young EHA Committee, representing Germany!
A well-earned recognition of his dedication and expertise in hematology.
Looking forward to the fresh perspectives he'll bring.
#YoungEHA #Hematology #EHA2025 #Germany

BCG revaccination failed to protect HIV-negative adolescents from sustained QFT test conversion and caused more adverse reactions.

by Schmidt AC, Fairlie L (...) Hatherill M et 13 al. in N Engl J Med #MedSky

👉 get more here

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2412381

Free online AlphaFold training on May 7, thanks to Fabian Glaser, Salomé Llabrés & Rune Matthiesen!

They'll start from the very basics & explore how this powerful tool is reshaping protein science.

Register here (required): forms.office.com/e/Hg3fe2Depm
Open to all, feel free to share!

#AlphaFold

Mutational signature catalogue (MUSIC) of DNA double-strand break repair https://www.biorxiv.org/content/10.1101/2025.04.29.650617v1

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer | NEJM The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...

A high polygenic risk score (PRS) for screening prostate cancer was superior to a PSA test or MRI for detecting clinically significant disease (Gleason ≥7). A big step forward for supporting utility of PRS @nejm.org
www.nejm.org/doi/full/10....

Review @cp-trendsimmuno.bsky.social @ostunilab.bsky.social
IL-1β+ macrophages and the control of pathogenic inflammation in cancer
www.cell.com/trends/immun...

Once more, exciting times ahead for young_eha 🌱

It was great to finally meet in person all new members & have time to discuss all the projects.

Specially excited with the kick-off of the mentorship program at the Congress 👏

📢 We have one vacancy, application is open!

YouTube video by Biostatsquid Gene Set Enrichment Analysis (GSEA) – simply explained!

Another Great Youtube Tutorials by Biostatsquid

GSEA Explanation
youtu.be/egO7Lt92gDY?...

GSEA Interpretation
youtu.be/Yi4d7JIlAsM?...

Thrilled to finally share our paper on how sex hormones and sex chromosomes interact to affect B cell class-switching!🥳 Diversity & inclusion in research recruitment = better science for all!😎 Thanks to @bcellsrosser.bsky.social@emmaschambers.bsky.social@arrdept-ucldom.bsky.social for ++ hard work!🌟

AI is transforming peer review — and many scientists are worried Artificial intelligence software is increasingly involved in reviewing papers, provoking interest and unease.

🧪 AI-written peer reviews are quietly reshaping science. Despite bans, reviewers are using LLMs to draft critiques, raising fears about shallow analysis, lost peer insight, and the erosion of trust. As @carlbergstrom.com states in the piece "Writing is thinking."
#AcademicSky

Es war mir eine Ehre und Freude, einen Teil beizutragen.

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress https://www.biorxiv.org/content/10.1101/2025.03.17.643278v1

Bluesky is the place for science.

Healing My Family’s Future How genetics and IVF empowered a family to leave cancer behind.

A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...

Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex https://www.biorxiv.org/content/10.1101/2025.03.14.643254v1

Last month I did a little experiment.

I wanted to see how the exact same post would perform on both X (Twitter) and Bluesky.

The results were...interesting...

[Thread]

Amazing collection of reviews on developmental hematopoiesis from leaders in the field. Just out in @iseh.bsky.social journal, Experimental Hematology www.exphem.org/content/edit...

Cancer cells can cooperate to grow Scientists found that, when deprived of amino acids, cancer cells cooperated to extract and share them from their environment.

#Medsky🧪#oncosky a fascinating research @NIH’s study found that cancer cells can cooperate with each other to extract and share key molecules from their environment in order to survive …
www.nih.gov/news-events/...
@nature.com
www.nature.com/articles/s41...

Some good tips on reducing microplastic intake
www.washingtonpost.com/climate-solu...

openRxiv has arrived!

We’re thrilled to announce the launch of openRxiv as an independent, researcher-led nonprofit to oversee bioRxiv and medRxiv, the world’s leading preprint servers for life and health sciences.
openrxiv.org/introducing-...

#openRxiv #OpenScience #Preprints #bioRxiv #medRxiv