The behind-the-scenes chemistry driving drug discovery Learn how scientists at St. Jude use chemistry to efficiently screen compounds and develop next generation targeted treatments.

Great article highlighting research in CBT!
bit.ly/DD_SJ
#drugdiscovery #Chembio @stjuderesearch.bsky.social

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors - Nature Communications Chemically induced protein degradation is a powerful alternative to classical inhibition, but some proteins have deeply masked binding pockets that make the development of degrader molecules difficult...

Another new paper alert fro CBT! Andrew Huber in the Chen Lab published work on degradation of nuclear receptors.
nature.com/articles/s41...
@StJudeResearch
#DrugDiscovery

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...

Excellent research out of the Lee Lab by
@stjudegraduate
student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases #DrugDiscovery

Kinase atlas uncovers hidden layers of cell signaling regulation See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.

New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2

Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.

St. Jude is hosting its annual Bringing Chemistry to Medicine Symposium October 2-3, 2025, in Memphis, TN. In collaboration with @cellpress.bsky.social, the event features global experts sharing cutting-edge advancements at the intersection of chemical and biomedical sciences.

Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!

Are you a #drughunter looking to have a direct impact on patients? The Department of Chemical Biology and Therapeutics is seeking a Principal Scientist in Chemical Induced Proximity to lead a new group.
talent.stjude.org/careers/jobs...

Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!

Are you a #drughunter looking to have a direct impact on patients? The Department of Chemical Biology and Therapeutics is seeking a Principal Scientist in Chemical Induced Proximity to lead a new group.
talent.stjude.org/careers/jobs...

Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!

We're hiring! CBT is seeking a principal scientist to led efforts in induced proximity strategies for drug discovery. Join our highly collaborative team!
talent.stjude.org/careers/jobs...

Study provides scaffold to selectively target drug breakdown process See how a panel of CYP3A4 inhibitors lay groundwork for selective cytochrome P450 inhibition by avoiding CYP3A5.

Cool stuff happening in the Chen Lab!
www.stjude.org/media-resour...

Stars by the Pocketful SWIR dyes─The Eras Tour. This love story between chemistry and biology shines.

Had a blast writing this piece celebrating the latest paper in @pubs.acs.org from @ellensletten.bsky.social and Ellen’s general awesomeness. My 11-year old daughter was my coauthor! (try to find all the Easter Eggs) pubs.acs.org/doi/10.1021/...

Way to go, Clara!