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Claudio Cortes

@clcortex.bsky.social

Scientist #devbio in congenital heart disease @Oxford #microscopyπŸ‡¨πŸ‡±πŸ‡¦πŸ‡ΊπŸ‡«πŸ‡·πŸ‡¬πŸ‡§ #SciComm/#SciArtπŸ”¬β™₯🧬// He/Him // Climbing - drumming - scuba

199 Followers  |  607 Following  |  11 Posts  |  Joined: 01.01.2024  |  1.6953

Latest posts by clcortex.bsky.social on Bluesky

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Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues Patho-DBiT enables spatial profiling of a range of RNA species (i.e., mRNA, microRNA, tRNA, splicing isoform, etc.) all at once in clinical formalin-fixed paraffin-embedded tissue with high sensitivit...

This is why we are all in this field…to see, and one day to be able to produce work like this.

Patho-DBiT-seq

www.cell.com/cell/fulltex...

29.11.2024 23:35 β€” πŸ‘ 46    πŸ” 10    πŸ’¬ 2    πŸ“Œ 0
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STAMP brings us non-destructive single-cell profiling without the sequencing No sequencer needed: Imaging based single-cell multiomics

STAMP brings us non-destructive single-cell profiling without the sequencing

www.omic.ly/stamp-brings...

03.07.2025 07:26 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. MOSAIC captures everything from subcellular dynamics to neural activity in live mice.
www.biorxiv.org/content/10.1...

16.06.2025 21:26 β€” πŸ‘ 29    πŸ” 9    πŸ’¬ 0    πŸ“Œ 1

Come and join us for a fantastic conference around all things human development and growth!

Lots of talks from abstracts and a stellar lineup of invited speakers? YES.

Hope to see you all there !

@wellcometrust.bsky.social

11.07.2025 14:05 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Help shape the Node’s future by taking part in their survey - FocalPlane Help shape the Node’s future by taking part in their survey - News

The Node, our sister site, is collecting feedback in their survey. If you are a developmental or stem cell biologist and can spare 5 minutes, please complete the survey to help shape the future of the site.
#DevBio #StemCells #CommunityBuilding
focalplane.biologists.com/2025/04/28/h...

28.04.2025 13:47 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

I like the ambition ! Choose France we will think about funding later. Never stop dreaming!

26.04.2025 15:59 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
A linocut print with four crows facing different directions and the words β€˜A murder of crows’. The first two words look like a typewriter typeface with β€˜murder’ in red followed by red crow footprints leading down to the crows. The word β€œcrows” is spelled in feathers.

A linocut print with four crows facing different directions and the words β€˜A murder of crows’. The first two words look like a typewriter typeface with β€˜murder’ in red followed by red crow footprints leading down to the crows. The word β€œcrows” is spelled in feathers.

Today is also International Crow and Raven Appreciation Day and I for one, appreciate the corvids. πŸ§ͺ🐑 They are extraordinarily intelligent birds! Here is my murder of crows, part of my terms of venery series of collective nouns for animals. 🧡

#linocut #printmaking

27.04.2025 13:15 β€” πŸ‘ 136    πŸ” 28    πŸ’¬ 2    πŸ“Œ 3
Is CoA a problem because an over-constrictive (flow-sensitive) SMC subpopulation of CNC origin has invaded the aortic zone, which is supposed to be populated by mesodermal SMCs?😁

Is CoA a problem because an over-constrictive (flow-sensitive) SMC subpopulation of CNC origin has invaded the aortic zone, which is supposed to be populated by mesodermal SMCs?😁

#CoarctationOfAorta
A developmental problem of #SmoothMuscleCell #BoundaryFormation?πŸ˜ƒ

"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"

#JDBMDPI 2025
www.mdpi.com/2221-3759/13...

27.04.2025 19:39 β€” πŸ‘ 11    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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C-SIDE
Cell type-specific inference of differential expression in #SpatialTranscriptomics

πŸ‘‰Work for both Sequencing- & Imaging-based ST
πŸ‘‰Need single-cell reference
πŸ‘‰Histological features as covariates
πŸ‘‰Pixel-based Segmentation-free DEA

@naturemethods.bsky.social 2022
www.nature.com/articles/s41...

28.04.2025 12:35 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

The #printPromptMonday prompt is portrait. Making scientist portraits plays a large part in my art practice, so there are so many to choose from!

Here’s a recent I was pleased with- crystallographer Dorothy Crowfoot Hodgkin πŸ§ͺπŸ‘πŸ‘©πŸΌβ€πŸ”¬ #histsci

28.04.2025 13:28 β€” πŸ‘ 31    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Two great new #Zebrafish preprints from the #WeinsteinLab using a new transgenic that reports epigenetic silencing and activation! Great to study epigenetic changes in vertebrates, and we even did an ENU screen. Excellent work by @mmarvel.bsky.social et al. πŸ§ͺ
www.biorxiv.org/content/10.1...

28.04.2025 14:14 β€” πŸ‘ 22    πŸ” 6    πŸ’¬ 1    πŸ“Œ 1
Smiling woman with brown hair, black jacket, green purse with a green baseball hat with a Gila monster on it, standing in front of a cherry tree covered in pink blossoms.

Smiling woman with brown hair, black jacket, green purse with a green baseball hat with a Gila monster on it, standing in front of a cherry tree covered in pink blossoms.

In December I accepted a position as a senior investigator at the NIH in the National Human Genome Research Institute & Center for Genomics and Data Science Research.

Bringing the party in the desert to Maryland.

We are hiring postdocs & postbacs!

Please reach out :)

28.04.2025 12:28 β€” πŸ‘ 200    πŸ” 58    πŸ’¬ 13    πŸ“Œ 4
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Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structuresβ€”similar to those of their dinosaur ancestorsπŸ”¬πŸ¦–πŸ§ͺ

journals.plos.org/plosbiology/...

21.03.2025 10:06 β€” πŸ‘ 117    πŸ” 37    πŸ’¬ 6    πŸ“Œ 4
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β€˜We’re living in the Twilight Zone’: Researchers decry Trump administration assault on science At the STAT Summit on Thursday, researchers called for a "full-throated defense" of university research again the attacks by the Trump administration.

β€œDo scientists put themselves at risk by speaking out against the Trump administration?
β€œHell yes,” said Jonathan Jackson, a national expert on increasing diversity in clinical trials… β€œI might lose the grants I have by the middle of next week” being on this stage…an answer that silenced the crowd”

21.03.2025 11:48 β€” πŸ‘ 34    πŸ” 25    πŸ’¬ 1    πŸ“Œ 1
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Cancelled NIH grant information submission form Please use this form to submit information identifying specific NIH grants that have been cancelled for any reason after January 20, 2025. Data from this form will be used to update the Rescinded NIH...

The crush of new grant cancellations hasn't let up.

If your grant was terminated (or your app was pulled) please use this Google FormπŸ‘‡ to submit details for tracking purposes.

Multiple advocacy efforts are moving forward, but we must must must know more about what grants were cancelled and why.

21.03.2025 03:32 β€” πŸ‘ 444    πŸ” 502    πŸ’¬ 10    πŸ“Œ 31
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Mitochondrial genetics, signalling and stress responses - Nature Cell Biology Auwerx and colleagues review recent advances in mitochondrial genetics, proteomics and biochemistry that emphasize the far-reaching impact of mitochondrial genetic variation and the role of mitochondr...

πŸ†•Interested in #mitochondria #genetics and their role in signaling? Read our latest Review article by Yasmine J. Liu, Jonathan Sulc & Johan Auwerx.
rdcu.be/eevUG
bit.ly/41LTD8z

21.03.2025 13:46 β€” πŸ‘ 16    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

New social network, who this? :D

21.03.2025 12:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Great work coming out of @saradv.bsky.social at @idrm.ox.ac.uk, getting the spotlight from Guille LuxΓ‘n (not on Bsky).

What makes a vessel? And more importantly, what regulates and maintains different vessel identities??

Read below to find out..

21.03.2025 11:53 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
Microscopy image of a 3-day old, genetically modified zebrafish expressing a new arterial enhancer driving a green reporter gene and a pan-endothelial marker (red).

Microscopy image of a 3-day old, genetically modified zebrafish expressing a new arterial enhancer driving a green reporter gene and a pan-endothelial marker (red).

Vascular Development: What determines whether an endothelial cell becomes part of an artery, a vein or a capillary?
elifesciences.org/articles/106...

20.03.2025 04:21 β€” πŸ‘ 22    πŸ” 9    πŸ’¬ 0    πŸ“Œ 2

Thank you to A. Franco, W. Hur and K. Hadjantonakis for a writing a great News & Views highlighting our last work published @naturemethods.bsky.social πŸ˜€πŸ‘‡:

20.03.2025 07:45 β€” πŸ‘ 19    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

Please also check out the News & Views highlighting this cool work!

www.nature.com/articles/s41...

19.03.2025 17:06 β€” πŸ‘ 18    πŸ” 4    πŸ’¬ 0    πŸ“Œ 3

Thank you to @ukri.org MRC for awarding our grant on the role of CHD3 in neural crest/craniofacial development (and associated syndromes), together with the brilliant @karenjliu.bsky.social! And in collaboration with @profsimonfisher.bsky.social
Exciting times!

20.03.2025 15:36 β€” πŸ‘ 17    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Two fully funded 4-year PhD positions, starting in October 2025, are available in the labs of Dr. Josana Rodriguez and Dr. Adam Wollman at Newcastle University Bioscience Institute. These projects are part of the NEEDL.
Follow the links for more information and how to apply.
Deadline: 31 March 2025

11.03.2025 11:38 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...

β€’ Happy to announce that our paper in @nature.com is finally out! Thanks to the perseverance of @taijamakinenlab.bsky.social and our many collaborators we finally pulled it off! A small 🧡

www.nature.com/articles/s41...
Laymen video:
www.nature.com/articles/d41...

20.03.2025 14:05 β€” πŸ‘ 37    πŸ” 12    πŸ’¬ 5    πŸ“Œ 5
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A toolkit for testing membrane localisation tags across species Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...

Looking for a tag to localise fluorescent proteins to the plasma membrane? Unsure which tag might work in your species? We generated a toolkit of 11 membrane-localising tags, which can be screened rapidly by microinjecting mRNA in your species of interest. 1/4
www.biorxiv.org/content/10.1...

12.11.2024 23:05 β€” πŸ‘ 122    πŸ” 60    πŸ’¬ 3    πŸ“Œ 2
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πŸ“£Exciting meeting ahead!
Join us at Shaping Life 3 in beautiful Cassis next June!
www.atoutcom.com/shaping-life/
@justinmcrocker.bsky.social @guignardlab.bsky.social @bulutkarslioglu.bsky.social @dudinlab.bsky.social @flowerwhatelse.bsky.social @laghalab.bsky.social @sfbd.bsky.social

18.11.2024 10:52 β€” πŸ‘ 70    πŸ” 40    πŸ’¬ 0    πŸ“Œ 4
Cardiac scratch wound assay to show the role of ECM in wound healing. HiPSC Cardiomyocytes in white on the boarders with a rich ECM scar tissues (cyan) through the middle with a simple nuclear stain (red) highlighting all cells.

Cardiac scratch wound assay to show the role of ECM in wound healing. HiPSC Cardiomyocytes in white on the boarders with a rich ECM scar tissues (cyan) through the middle with a simple nuclear stain (red) highlighting all cells.

How to fix a broken #heart πŸ’”->❀️

#Proteoglycan rich #ECMatrix scar tissue is laid by migratory cells after a cardiac scratch wound with #hiPSC #Cardiomyocytes.

Happy #Fluorescencefriday #BlueSky & #CardioSky!

@ablanchasensio.bsky.social πŸ‘€
#Science πŸ’₯πŸ§ͺ #Microscopy πŸ”¬

13.12.2024 15:22 β€” πŸ‘ 61    πŸ” 12    πŸ’¬ 0    πŸ“Œ 0

#CoolJob alert 🚨🚨

Live imaging? Check
Supportive mentor? Check
Positive lab culture? Check
Great location? Check

Apply now!

13.03.2025 17:52 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Elly Tanaka, IMBA’s Scientific Director, receives the Schleiden Medal of the German National Academy of Sciences Leopoldina, honoring her groundbreaking insights in the field of regenerative biology. Congratulations! Read more here: imba.science/schleidenmedal

12.03.2025 10:02 β€” πŸ‘ 60    πŸ” 12    πŸ’¬ 5    πŸ“Œ 1

Just saw the latest from Berta's lab, apply now for this very exciting postdoc opportunity on fish, vertebrae and evolution!

🐟🐠🐑

10.02.2025 11:46 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

@clcortex is following 20 prominent accounts