Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans - Nature Communications The underlying mechanism of electroconvulsive therapy remains not fully understood. Here, the authors use optical neuroimaging in mice and humans to show that electroconvulsive therapy elicits a secon...

Hot off the press! We found that electroconvulsive therapy (ECT) induces a previously undescribed, second brain event after seizure, called cortical spreading depolarization (CSD), using optical neuroimaging in both a mouse model to human patients. 🧵 below!

doi.org/10.1038/s414...

Use of ECT in Adolescents in Singapore: New Data in JECT Ouit on PubMed, from investigators in Singapore, is this study: Use of Electroconvulsive Therapy Treatment in Adolescents in Singapore. Che...

I don’t know if Charlie Kellner has a BlueSky, but if you don’t follow his ECT Blog, you should!

He finds interesting articles and includes his own commentary on the value of the paper:

ectpsych.blogspot.com/2025/02/use-...

Mystery Medicine Monday (best I could come up with):
Propylene glycol toxicity always comes up as a concern with high dose parenteral Ativan, has anyone experienced this in clinical practice? I have given large doses of Ativan and have yet to encounter a case.

regarding the risks and benefits of treatments/interventions. Failing to appreciate the significant, far reaching, neurocognitive impact of depressive illnesses can lead to settling for partial or inadequate treatment responses.

In clinical practice, the results of this study align with what we see: Psychiatric illnesses, especially depressive illness, can have significant effects on cognitive functioning, and adequate appreciation of this reality allows both patients and providers to engage in a more nuanced discussion

Without delving into the greater question of BL vs RUL, this study underscores the importance of the primary goal of treatment - to induce remission of depressive symptoms, and points to the fact that adequate treatment of depressive symptoms will be a central factor in cognitive outcomes.

There is a constant effort, on the treating psychiatrist, to reduce the risk of adverse cognitive outcomes, which often manifests in the preferential selection of unilateral and ultra-brief pulse.

2) technical parameters re: ECT treatment were not independently associated with adverse cognitive outcomes.

The second point is what is most important, in my mind. We are limited by our study durations re: differences in cognitive outcomes with varying electrode placement, etc.

Who is at risk of long-term subjective memory impairment after electroconvulsive therapy? Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory i…

www.sciencedirect.com/science/arti...

This is an important and excellent study on one of the major concerns with ECT in regards to cognitive outcomes. It sheds light on a few important points: 1) persistent depressive symptoms are deleterious to cognitive function and 2)