Peter Hsu

Degrons and degradation signals beyond short linear motifs - Nature Chemical Biology Degrons are degradation signals in target proteins to direct recognition and degradation by the ubiquitin–proteasome system. Wang et al. introduce degrons of different types, with an emphasis on high-...

A new Review discusses how degrons of different types, with an emphasis on high-order structural ones, regulate substrate-E3 interactions and how their dysregulation is linked to human diseases

www.nature.com/articles/s41...

Will the Senate Save NIH? Rescuing biomedical research is every bit as important as saving Medicaid.

It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.

prospect.org/politics/202...

a cartoon of a man holding a frying pan and a spoon with red alert written above him ALT: a cartoon of a man holding a frying pan and a spoon with red alert written above him

ATTENTION: NSF GRANT RECIPIENTS

We received a heads up from a trusted source that you should proactively download/print/screen shot any documentation on research.gov pertaining to your NSF awards, both those that are current and any that have closed in the last 5-6 years.

1/n

Everyone please read and act! 👇

Well, I have been studying the Republican Party for over 12 years at close hand in the Capital of the United States. And by this time, I have discovered where the Republicans stand on most of the major issues. Since they won't tell you themselves, I am going to tell you. They approve of the American farmer-but they are willing to help him go broke. They stand four-square for the American home--but not for housing. They are strong for labor--but they are stronger for restricting labor's rights. They favor a minimum wage--the smaller the minimum the better. They indorse educational opportunity for all--but they won't spend money for teachers or for schools. They think modern medical care and hospitals are fine--for people who can afford them. They approve of social security benefits-so much so that they took them away from almost a million people. They believe in international trade--so much so that they crippled our reciprocal trade program, and killed our International Wheat Agreement. They favor the admission of displaced persons--but only within shameful racial and religious limitations. They consider electric power a great blessing-but only when the private power companies get their rake-off. They say TVA is wonderful--but we ought never to try it again. They condemn "cruelly high prices"--but fight to the death every effort to bring them down. They think the American standard of living is a fine thing--so long as it doesn't spread to all the people. And they admire the Government of the United States so much that they would like to buy it.

From the law community on Reddit: The full Executive Order is out! ⚠️ This is the biggest executive power grab in U.S. history. ⚠️ Explore this post and more from the law community

www.reddit.com/r/law/s/g7Rb...

Sickening, horrifying, and we all need to assemble to stand up

This is such an incredible explainer of Indirect Funding!

💡 Some takeaways:

🧬 The federal science funding landscape in America was created after the US economy, security, and health by partnering with universities that would conduct research for the government.

🧵

YouTube video by House Science, Space, and Technology Committee Adoption of Committee Rules & Approval of Authorization & Oversight Plan

The House Science Committee is now adopting its rules, authorization, and oversight plan, and introducing their new staffers. Immediately following, there will be a hearing on the future of U.S. science with the president of AAAS and two former Trump officials in academia and Trump operative.

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

So many people added to pack 1 this weekend we had to make pack 2. Makes sure you refresh for followers on pack one to see them all!
🧶🧬

go.bsky.app/DDetSBp

US should be leading this charge. We are not. How sad is that?