Oncolytic virus VG161 in refractory hepatocellular carcinoma | Nature
Hepatocellular carcinoma remains a life-threatening malignancy with limited therapeutic options following the failure of second-line treatments1,2. Oncolytic viruses selectively replicate in and lyse cancer cells, releasing neoantigens and stimulating systemic antitumour immunity3, offering a potential therapeutic option. Here we present the results of a multicentre phase 1 clinical trial evaluating VG161, an engineered oncolytic herpes simplex virus that expresses IL-12, IL-15, IL-15RΞ± and a PD-1βPD-L1-blocking fusion protein4, for safety and efficacy in patients with advanced liver cancer. VG161 was well tolerated, with no dose-limiting toxicities observed, and it demonstrated promising efficacy by reshaping the tumour immune microenvironment and re-sensitizing tumours that were previously resistant to systemic treatments. Notably, we also found that patients who had previously been sensitive to checkpoint inhibitor therapy showed enhanced efficacy with VG161 treatment. Furtherm
VG161, an engineered virus, shows promise in a phase 1 trial for resistant liver cancer. A new hope for patients after second-line failures! PMID:40108464, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08717-5 #Medsky #Pharmsky #RNA #ASHG #ESHG π§ͺ
02.04.2025 03:10 β π 20 π 6 π¬ 0 π 0
All you need to know about Twitter
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Elbows up, Canada.
22.03.2025 22:11 β π 52546 π 13421 π¬ 1497 π 2307
Nothing to see hereβjust a sitting U.S. president pumping his shitcoin, after countless Americans have already lost billions investing in it.
The most corrupt president in history, by far
23.03.2025 15:47 β π 19751 π 4623 π¬ 1132 π 375
Thank all that is holy for Bluesky π¦
24.11.2024 01:04 β π 33716 π 4733 π¬ 575 π 205
When people show you who they are?
Believe them!
When Putin is delighted?
Be afraid, be very afraid for America & democracy
newrepublic.com/post/188705/...
24.11.2024 14:35 β π 91 π 24 π¬ 2 π 0
www.nytimes.com/2024/11/24/u...
25.11.2024 05:24 β π 0 π 0 π¬ 0 π 0
Heβs still at Mar-a-Lago. Elonia just moved right in and took over.
25.11.2024 02:39 β π 11098 π 1717 π¬ 1528 π 213
www.crikey.com.au/2024/11/25/e...
25.11.2024 03:05 β π 0 π 0 π¬ 0 π 0
anyone else liking this new social space?
14.11.2024 09:35 β π 0 π 1 π¬ 0 π 0
Literally..
22.11.2024 13:57 β π 87386 π 7258 π¬ 1975 π 303
Canada's national newspaper, but on Bluesky
WE DON'T MAKE DRONES
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