Oncolytic virus VG161 in refractory hepatocellular carcinoma | Nature Hepatocellular carcinoma remains a life-threatening malignancy with limited therapeutic options following the failure of second-line treatments1,2. Oncolytic viruses selectively replicate in and lyse cancer cells, releasing neoantigens and stimulating systemic antitumour immunity3, offering a potential therapeutic option. Here we present the results of a multicentre phase 1 clinical trial evaluating VG161, an engineered oncolytic herpes simplex virus that expresses IL-12, IL-15, IL-15Rα and a PD-1–PD-L1-blocking fusion protein4, for safety and efficacy in patients with advanced liver cancer. VG161 was well tolerated, with no dose-limiting toxicities observed, and it demonstrated promising efficacy by reshaping the tumour immune microenvironment and re-sensitizing tumours that were previously resistant to systemic treatments. Notably, we also found that patients who had previously been sensitive to checkpoint inhibitor therapy showed enhanced efficacy with VG161 treatment. Furtherm

VG161, an engineered virus, shows promise in a phase 1 trial for resistant liver cancer. A new hope for patients after second-line failures! PMID:40108464, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08717-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

All you need to know about Twitter

Elbows up, Canada.

Nothing to see here—just a sitting U.S. president pumping his shitcoin, after countless Americans have already lost billions investing in it.

The most corrupt president in history, by far

Thank all that is holy for Bluesky 🦋

When people show you who they are?
Believe them!
When Putin is delighted?
Be afraid, be very afraid for America & democracy
newrepublic.com/post/188705/...

www.nytimes.com/2024/11/24/u...

He’s still at Mar-a-Lago. Elonia just moved right in and took over.

www.crikey.com.au/2024/11/25/e...

anyone else liking this new social space?

Literally..