Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity Clonal recruitment is governed by a T cell receptor avidity threshold, whereas probabilistic expansion preserves repertoire polyclonality.

Vaccination-induced T cell responses maintain polyclonality with high antigen receptor avidity | Science Immunology www.science.org/doi/10.1126/...

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization | Science Immunology www.science.org/doi/10.1126/...

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies.

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates | Science Immunology www.science.org/doi/10.1126/...

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models HIV bNAb precursors to multiple epitopes can be primed by germline-targeting mRNA-LNP immunogens in mouse models.

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models | Science Immunology www.science.org/doi/10.1126/...

A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge LION-delivered replicating RNA vaccines are immunogenic and protect cynomolgus macaques against lethal influenza A (H5N1) virus challenge.

A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge | Science Translational Medicine www.science.org/doi/10.1126/...

Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles Elicit Broad Antibody Responses Four seasonal endemic human coronaviruses (EhCoVs), HKU1-CoV, OC43-CoV, 229E-CoV, and NL63-CoV, are culprits of mild upper respiratory and periodic severe diseases in vulnerable populations. Despite t...

www.biorxiv.org/content/10.1...

Enhanced human antigen-specific B cell responses using in vitro 3D tonsil cultures containing stromal cells The structural complexity of secondary lymphoid organs (SLOs) and their role in shaping antigen-specific B cell responses, pose significant challenges in modeling human germinal center (GC) response i...

www.biorxiv.org/content/10.1...

mRNA-based tuberculosis vaccines BNT164a1 and BNT164b1 are immunogenic, well-tolerated and efficacious in rodent models We designed and preclinically tested two mRNA-LNP-based vaccine candidates to protect against tuberculosis (TB). BNT164a1 and BNT164b1 encode the same eight Mycobacterium tuberculosis (Mtb) antigens e...

www.biorxiv.org/content/10.1...

Re-shaping the immune response to influenza vaccination in a host with immune memory from influenza https://www.biorxiv.org/content/10.1101/2025.10.01.678836v1

Anti-Malaria Antibody Engineering Broadens Recognition Motifs and Reveals New Homotypic Interactions that Enhance Protective Breadth https://www.biorxiv.org/content/10.1101/2025.09.30.679367v1

An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques Two doses of an inactivated trivalent vaccine protect mice and macaques against disease caused by encephalitic alphaviruses.

An inactivated trivalent virion-based vaccine protects against aerosol challenge with encephalitic alphaviruses in mice and macaques | Science Translational Medicine www.science.org/doi/10.1126/...

A single-dose nanoparticle vaccine protects against mpox in preclinical models @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers
www.nature.com/articles/s41...

HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs As a chronically replicating virus, HIV has evolved extreme sequence variability and effective shielding of functionally constrained spike protein determinants by host-derived glycans. Broadly neutral...

www.biorxiv.org/content/10.1...

Sarbecovirus Rc-o319 S-Protein Structures Reveal Highly Specialized Adaptation to Rhinolophus cornutus ACE2 Sarbecoviruses, represented by SARS-CoV-1 and SARS-CoV-2, utilize their spike (S) proteins to bind host ACE2 receptors and initiate infection. Here, we characterize the S-protein of Rc-o319, a sarbeco...

www.biorxiv.org/content/10.1...

Mechanisms for cross–neutralisation of diverse bat sarbecoviruses The continuing evolution of SARS–CoV–2 variants of concern, and the increasing spillover potential of sarbecoviruses into the human population presents an important and urgent need to discover cross-r...

www.biorxiv.org/content/10.1...

Structural and Mechanistic Basis for Antibody Neutralization of the Measles Fusion Protein Measles virus (MeV) is a highly contagious viral pathogen and remains a major global health threat. Resurgent infections, driven by insufficient vaccine coverage, waning herd immunity, and the vulnera...

www.biorxiv.org/content/10.1...

B Cells and Plasma Cells: Fundamental and Translational Biology | Keystone Symposia Join us at the Keystone Symposia on B Cells and Plasma Cells: Fundamental and Translational Biology, March 2026, in Keystone, with field leaders!

keysym.us/KSBCells26

Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.

Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity | Science Translational Medicine www.science.org/doi/10.1126/...

High-throughput synthesis and specificity characterization of natively paired influenza hemagglutinin antibodies with oPool+ display oPool+ display enabled rapid antibody synthesis and screening of influenza hemagglutinin-specific antibodies.

High-throughput synthesis and specificity characterization of natively paired influenza hemagglutinin antibodies with oPool+ display | Science Translational Medicine www.science.org/doi/10.1126/...

The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins A longitudinal analysis after XBB.1.5 COVID-19 vaccination revealed durable neutralizing antibodies against ancestral and recent SARS-CoV-2 variants.

The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins | Science Translational Medicine www.science.org/doi/10.1126/...

Progress on understanding membrane fusion in Poxviruses!

Congrats to the authors on this important work.

Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria npj Vaccines - Virus-like particle vaccines targeting a key epitope in circumsporozoite protein provide sterilizing immunity against malaria

rdcu.be/eCwcb

Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization npj Vaccines - Matrix-M adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

rdcu.be/eCv9N

Stabilization of norovirus GII.3 virus-like particles by rational disulfide engineering npj Vaccines - Stabilization of norovirus GII.3 virus-like particles by rational disulfide engineering

rdcu.be/eCv8B

Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques npj Vaccines - Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques

rdcu.be/eCv7r

HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates A germline-targeting trimer consistently induced rare bnAb-like precursors specific for the HIV Env Apex in rhesus macaques.

HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates | Science Immunology www.science.org/doi/10.1126/...

COVID-19 vaccine type controls stromal reprogramming in draining lymph nodes Different COVID-19 vaccine formulations have distinct effects on the stromal cell landscape and function of draining lymph nodes.

COVID-19 vaccine type controls stromal reprogramming in draining lymph nodes | Science Immunology www.science.org/doi/10.1126/...

Structural Repertoire of HCV Broadly Neutralizing Antibodies Targeting the E2 Front Layer Supersite Structural studies of the hepatitis C virus (HCV) E2 glycoprotein in complex with broadly neutralizing antibodies (bNAbs) have been instrumental in mapping neutralizing epitopes and guiding the ration...

www.biorxiv.org/content/10.1...

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM Protein structure tool ModelAngelo enhances speed and objectivity of polyclonal cryo-EM analysis to find protective antibodies.

Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM | Science Advances www.science.org/doi/10.1126/...