Gyunghee Jo

Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses Influenza virus cross-subtype antibodies targeting the hemagglutinin (HA) head are rare. Here, we found that a large proportion of monoclonal antibodies (mAbs) isolated from individuals immunized with...

I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/
www.medrxiv.org/content/10.1...

Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies - Nature Communications Monoclonal antibodies targeting the conserved neuraminidase catalytic site mimic sialic acid and use coordinated water molecules to inhibit diverse influenza A and B viruses, including H5N1, providing...

Published back-to-back with a beautifully done study by Lederhofer & Borst et al., who identified antibodies with a similar recurring motif and explored their function through structural and in vivo studies🧪🐁
doi.org/10.1038/s414...

Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3 - Nature Communications Recurrent features in human antibodies targeting the influenza neuraminidase active site reveal a convergent strategy of receptor mimicry, providing structural insights that could guide the design of ...

Just published in Nature Communications!🎆

We show how a recurring motif in antibody CDR H3 mimics sialic acid at the influenza neuraminidase active site, allowing broad binding and making it a promising vaccine target!💡🦠
doi.org/10.1038/s414...

Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1 Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed mill

Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1

Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3 https://www.biorxiv.org/content/10.1101/2024.11.26.625467v1 Influenza viruses evolve rapidly, driving seasonal epidemics and posing global pandemic threats. Whi

Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3 https://www.biorxiv.org/content/10.1101/2024.11.26.625467v1