Reconstructing Alzheimer’s disease one cell type at a time using in vitro tricultures In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…

I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper!

www.sciencedirect.com/science/arti...

29.07.2025 15:00 — 👍 4    🔁 2    💬 0    📌 2

Honored to have our work featured!Huge thanks for highlighting our triculture Alzheimer’s model!

31.07.2025 11:49 — 👍 7    🔁 1    💬 0    📌 0

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

Excited to share that our paper describing the establishment of our iPSC-derived triculture model is finally out in @cp-cellreports.bsky.social! Using this system, we show how the co-culture environment shapes cell responses, with a particular focus on microglia!

www.cell.com/cell-reports...

04.06.2025 20:03 — 👍 1    🔁 0    💬 0    📌 0

🎓Congratulations to our incredible grads! 🎉
Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂
We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish.bsky.social

31.05.2025 15:44 — 👍 5    🔁 1    💬 0    📌 0

Alzheimer’s Risk Variants Leave Astrocytes CLUless | ALZFORUM

Excited to see our recent study featured on Alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read the full story here!

15.05.2025 09:45 — 👍 11    🔁 1    💬 0    📌 0

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...

30.04.2025 15:56 — 👍 21    🔁 9    💬 0    📌 0

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…

Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.

Read here www.sciencedirect.com/science/arti...

30.04.2025 15:51 — 👍 37    🔁 20    💬 1    📌 0

Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!

28.02.2025 22:16 — 👍 15    🔁 4    💬 0    📌 2

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease Generation and characterization of induced pluripotent stem cell (iPSC)-derived astrocytes from 44 aged humans reveals congruence of gene expression profiles between astrocyte cultures and brain and ...

New TYP lab publication out today in Glia, led by talented previous PhD student Hyo Lee! Our first big analysis of induced Astrocytes from 44 individuals in the ROSMAP cohort.
You can find it here: onlinelibrary.wiley.com/doi/10.1002/...

04.02.2025 14:27 — 👍 6    🔁 3    💬 0    📌 0