Thank you

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏

www.cell.com/cell/abstrac...

#chemsky

Thank you @nplb.bsky.social for speaking out in defense of patients, the US economy and our citizenship. Encouraged to see biopharma and investors among patients, health care providers, scientists and policy makers.

www.nopatientleftbehind.org/defending-th...

Better not call it a “vaccine” or it might not get approved. Maybe market it as a recreational drug.

When Rupert Murdoch’s rags turn on you …

Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...

New @biorxivpreprint.bsky.social preprint from Amgen induced proximity group and @dannomura.bsky.social lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7 www.biorxiv.org/content/10.1...

Looks bad

Got word that several NIH employees in a group working on cancer clinical trials got terminated via email this evening.

“The [cancer research] trials will literally not be able to function without us.”

Trump and Musk are killing cancer research. 🧪

So sorry for you loss.

You can sell with the truth. It’s still about presentation.
“Inflation is painful for everyone. But what can destroy a family, the price of Gatorade going up , or the price of medications not being affordable? The republicans have a concept of a plan for drug pricing. We have a solution.

a man with glasses and a mustache is making a sad face ALT: a man with glasses and a mustache is making a sad face

(Sorry I took a brief timeout for uncontrollable weeping)

In other NIH news, I have heard from multiple sources that NIH plans to fire most, if not all, probationary employees this afternoon. The numbers I am hearing are >5000.

Lots of folks extramural staff, intramural scientists, etc.

Folks: I am NOT affiliated with the group that is using my name to support an economic boycott. Please spread this post, if you would.

A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion - Nature A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.

Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it)

www.nature.com/articles/s41...

Well said @dereklowe.bsky.social. Academia produces two vital products: (1) knowledge, and (2) human capital that knows how to use it. If we can’t train enough young creative US scientists to fulfill biopharma industry needs…

“I think they're being short-sighted, because fear does that to you.”

YouTube video by Association of American Universities Facilities and Administrative (F&A) Costs Explainer

This youtube video, also from AAU, is great for friends and families that might not understand. www.youtube.com/watch?v=yxTD...

This is outstanding! Watch it and share...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Stand Up And Be Counted

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.

Silence gives consent. And no one should consent to this.

Mark Cuban on NIH.
Yes. Public money also funded the basis of Netscape, Google, Intel, and Moderna. Those companies wouldn’t be in the US without government funding science. 1/2

NIH doesn’t just support infectious disease research—it drives breakthroughs in cancer, childhood diseases, heart disease, diabetes & more.

Thanks to NIH, we have:
💉 Cancer immunotherapy
❤️ Cholesterol-lowering statins
🩸 Insulin for diabetes

Investing in NIH = investing in life-saving discoveries.

a picture of a cartoon character with the words call me on it ALT: a picture of a cartoon character with the words call me on it

F99/R00 AND K99/R00 DIVERSITY AWARD APPLICANTS

If you have applied for a F99/R00 or K99/R00 Diversity award and the study section for review is not listed on your eRA Commons page, please reach out to me.

DM me, email berg.grants.2029@gmail.com, Signal jeremymberg.78

THANK YOU

Contacting your congressperson is fine.

But contacting your local TV station is better.

One interview on local TV saying your congressperson should act is worth 1,000 office calls.

The NIH cuts are being spun as a way to eliminate bloated university bureaucracy. And looking at the sheer numbers, I get it.

But in fact the story is the exact opposite. The federal research grants system is highly efficient. And it super charges American innovation. 🧵

1/

NIH cuts billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.

www.washingtonpost.com/health/2025/...

Executive wants to frame the NIH indirects cut as $4B in savings.

But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

Straight into court, and you can expect universities to be seeking injunctive relief immediately. This is the way Trump has always conducted himself, lawless and without honor or compunction.

Today they went nuclear.

Imagine all firefighters were told "You all still have salaries, but as of today the government will no longer pay for building maintenance, firetruck maintenance and repair, hydrant upkeep, or admin assistants."

That's what they're doing to US universities.

The NIH overhead cut doesn't just hurt universities.

It's deadly to the US economy.

The US is a world leader in tech due to the ecosystem that NIH and NSF propel. It drives innovation for tech transfer, creates a highly-skilled sci/tech workforce, and fosters academic/industry crossfertilization.